Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

Joints That Could Heal Themselves? Researchers Could Get There in 5 Years

[University of Colorado] At the first inkling of a creaky knee, patients could get a single shot in the joint that would not only stop their cartilage and bone from eroding, but kick start its regrowth. That may seem like a dream, but the Advanced Research Projects Agency for Health awarded up to $39 million to a University of Colorado Boulder-led team of scientists to work toward making it a reality.

Mechanical Properties of Native and Decellularized Reproductive Tissues: Insights for Tissue Engineering Strategies

[Scientific Reports] Researchers investigated the changes in Young's modulus, storage modulus, loss modulus, and porosity of native and decellularized bovine reproductive tissues during the estrous cycle.

Silk Fibroin Hydrogel Adhesive Enables Sealed-Tight Reconstruction of Meniscus Tears

[Nature Communications] Scientists designed a dual functional biologic-released bioadhesive comprised of methacrylated silk fibroin crosslinked with phenylboronic acid-ionic liquid loading with growth factor TGF-β1, which integrated chemo-mechanical restoration with inner meniscal regeneration.

Cancer Cell Genetics Shaping of the Tumor Microenvironment Reveals Myeloid Cell-Centric Exploitable Vulnerabilities in Hepatocellular Carcinoma

[Nature Communications] In newly generated, clinically-relevant somatic female HCC mouse models, investigators identified cancer genetics’ specific and stage-dependent alterations of the liver tumor microenvironment associated with distinct histopathological and malignant HCC features.

MOFs and MOF-Based Composites as Next-Generation Materials for Wound Healing and Dressings

[Small] Metal–organic frameworks (MOF)-based composites promote cell proliferation, angiogenesis, and matrix synthesis, acting as carriers for bioactive molecules and promoting tissue regeneration.

Mapping Functional to Morphological Variation Reveals the Basis of Regional Extracellular Matrix Subversion and Nerve Invasion in Pancreatic Cancer

[Cancer Cell] Researchers identified three major morphological and functional variants that co-existed in varying proportions in all PDACs, displayed limited genetic diversity, and were associated with a distinct organization of the ECM.

Predictive Value of Procollagen C-Protease Enhancer Protein on the Prognosis of Glioma Patients

[Heliyon] Multiple bioinformatics techniques have been employed to investigate the roles of procollagen c-protease enhancer protein (PCOLCE) in glioma, consisting of the correlation between PCOLCE and prognosis, immune checkpoints, immune cell infiltrates, and tumor microenvironment.

Bioengineering Full-Scale Auricles Using 3D-Printed External Scaffolds and Decellularized Cartilage Xenograft

[Acta Biomaterialia] Using a small animal “bioreactor”, investigators bioengineered full-scale ears utilizing decellularized cartilage xenograft placed within a 3D-printed external auricular scaffold that mimics the size, shape, and biomechanical properties of the native human auricle.

Platelet Rich Fibrin and Simvastatin-Loaded Pectin-Based 3D Printed-Electrospun Bilayer Scaffold for Skin Tissue Regeneration

[International Journal Of Biological Macromolecules] A bilayer scaffold with a top layer comprising 3D printed pectin/polyacrylic acid/platelet rich fibrin hydrogel and a bottom nanofibrous layer containing Pec/PAA/simvastatin was produced.

Autophagy Induced by Low Shear Stress Leads to Endothelial Glycocalyx Disruption

[Journal Of Vascular Research] Human umbilical vein endothelial cells were subjected to physiological shear stress and low shear stress treatments, followed by the application of autophagy inducers and inhibitors. Additionally, cells were treated with specific matrix metalloproteinase-2 and matrix metalloproteinase-9 inhibitor.

The Role of Matrix Metalloproteinase-2 and miR-196a2 in Bronchial Asthma Pathogenesis and Diagnosis

[Heliyon] Researchers investigated the underlying mechanisms and clinical relevance of miR-196a2 and MMP-2 serum levels in relation to the severity of asthma.

Human Dental Pulp Stem Cells Derived Extracellular Matrix Promotes Mineralization via Hippo and Wnt Pathways

[Scientific Reports] Researchers investigated the efficacy of decellularized ECM derived from human dental pulp stem cells and gingival-derived MSCs as an inductive scaffold for osteogenic differentiation of GSCs.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.

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