Volume 6.23 | Jun 18

Extracellular Matrix News 6.23 June 18, 2015
Extracellular Matrix News
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Researchers Discover Molecule that Accelerates Tissue Regeneration after Bone Marrow Transplants
Researchers identified an enzyme named 15-PGDH that regulates tissue regeneration in multiple organs. By blocking 15-PGDH in mice with the newly discovered molecule, SW033291, they found that they can rescue damaged bone marrow, liver tissue, and colon tissue. [Press release from The University of Texas Southwestern Medical Center discussing online prepublication in Science] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Aligned-Braided Nanofibrillar Scaffold with Endothelial Cells Enhances Arteriogenesis
Investigators sought to enhance the angiogenic capacity of endothelial cells (ECs) using nanoscale signaling cues from aligned nanofibrillar scaffolds in the setting of tissue ischemia. Human ECs showed greater outgrowth from aligned scaffolds than from nonpatterned scaffolds. [ACS Nano] Abstract | Graphical Abstract

Artificial Membrane-Binding Proteins Stimulate Oxygenation of Stem Cells during Engineering of Large Cartilage Tissue
Scientists showed that pre-treating human mesenchymal stem cells with synthetic membrane-active myoglobin-polymer–surfactant complexes can provide a reservoir of oxygen capable of alleviating necrosis at the center of hyaline cartilage. [Nat Commun] Full Article | Press Release

Targeting of β1 Integrins Impairs DNA Repair for Radiosensitization of Head and Neck Cancer Cells
Researchers examined the impact of β1 integrin targeting on the repair of radiation-induced DNA double-strand breaks (DSBs). β1 integrin targeting impaired repair of radiogenic DSB in vitro and in vivo and reduced the protein expression of Ku70, Rad50 and Nbs1. [Oncogene] Abstract

Stromal miR-200s Contribute to Breast Cancer Cell Invasion through CAF Activation and ECM Remodeling
Investigators found that miR-200s, which are generally downregulated in activated cancer-associated fibroblasts (CAFs) in breast cancer tissues and in normal fibroblasts (NFs) activated by breast cancer cells, are direct mediators of NF reprogramming into CAFs and of extracellular matrix (ECM) remodeling. [Cell Death Differ] Full Article

Simple Coating with Fibronectin Fragment Enhances Stainless Steel Screw Osseointegration in Healthy and Osteoporotic Rats
The authors present a simple coating strategy based on passive adsorption of FN7-10, a recombinant fragment of human fibronectin encompassing the major cell adhesive, integrin-binding site, onto 316-grade stainless steel (SS). FN7-10 coating on SS surfaces promoted α5β1 integrin-dependent adhesion and osteogenic differentiation of human mesenchymal stem cells. [Biomaterials] Abstract

A 3D Human Neural Cell Culture System for Modeling Alzheimer’s Disease
Scientists provide instructions for the generation and analysis of 3D human neural cell cultures, including the production of genetically modified human neural progenitor cells (hNPCs) with familial Alzheimer’s disease (AD) mutations, the differentiation of the hNPCs in a 3D matrix and the analysis of AD pathogenesis. [Nat Protoc] Abstract

Quantification of Regenerative Potential in Primary Human Mammary Epithelial Cells
Researchers present an organoid regeneration assay in which freshly isolated human mammary epithelial cells are cultured in adherent or floating collagen gels, corresponding to a rigid or compliant matrix environment. In both conditions, luminal progenitors form spheres, whereas basal cells generate branched ductal structures. [Development] Abstract | Full Article | Press Release

Skin Rejuvenation with Non-Invasive Pulsed Electric Fields
The authors report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. [Sci Rep]
Full Article | Press Release

Synoviocyte Derived-Extracellular Matrix Enhances Human Articular Chondrocyte Proliferation and Maintains Re-Differentiation Capacity at Both Low and Atmospheric Oxygen Tensions
Porcine synoviocyte-derived extracellular matrix and low oxygen tension were assessed for their ability to enhance human articular chondrocyte expansion and maintain re-differentiation potential. Human chondrocytes expanded twice as fast on devitalized synoviocyte matrix vs. tissue culture plastic, and cells retained their re-differentiation capacity for twice the number of population doublings. [PLoS One] Full Article

Nitric Oxide Regulates Cell Behavior on an Interactive Cell-Derived Extracellular Matrix Scaffold
Researchers investigated the regulatory effect of nitric oxide (NO) on human mesenchymal stem cells in an interactive extracellular matrix (ECM)-rich microenvironment. In order to mimic the in vivo stromal environment in wound site, a cell-derived ECM scaffold that was able to release NO within the range of in vivo wound fluid NO level was fabricated. [J Biomed Mater Res A] Abstract

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The Hypoxic Tumor Microenvironment: A Driving Force for Breast Cancer Progression
Recent preclinical studies suggest that the combination of cytotoxic chemotherapy with drugs that inhibit hypoxia-inducible factors may improve outcome for women with triple-negative breast cancer. [Biochim Biophys Acta] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
NTCELL® Clinical Study in Parkinson’s Meets Endpoints
Living Cell Technologies Limited announced results from a Phase I/IIa clinical study of NTCELL®, an experimental regenerative cell therapy being studied as a disease-modifying agent in Parkinson’s disease. [Press release from Living Cell Technologies Limited discussing research presented at the 19th International Congress of Parkinson’s Disease and Movement Disorders, San Diego] Press Release

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CorMatrix®  Cardiovascular, Inc. Receives Two Additional U.S. Patents for ECM® Biomaterial Compositions
CorMatrix® Cardiovascular, Inc. announced the issuance of U.S. Patent No. 9,034,367 entitled Articles for Tissue Regeneration with Biodegradable Polymers. The patent covers grafts and compositions comprising a variety of extracellular matrix (ECM®) materials, including small intestine submucosa, stomach submucosa, liver basement membrane and urinary bladder submucosa.  [CorMatrix® Cardiovascular, Inc.] Press Release

AxoGen, Inc. Announces Completion of a Pilot Clinical Study Assessing Cavernous Nerve Reconstruction with Avance® Nerve Graft following Radical Prostatectomy
AxoGen, Inc. announced results from a pilot clinical study of cavernous nerve reconstruction during radical prostatectomy procedures using its Avance® Nerve Graft. [AxoGen, Inc.] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Cell Culture 2016
February 2-4, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Research Associate – Novel Therapeutics and Biomarkers in Peripheral Ischemia (University of Bristol)

Associate Scientist – Biomedical Engineering (Shanghai Jiao Tong University)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Postdoctoral Fellow – Neural Tissue Engineering (Nanyang Technological University)

Postdoctoral Position – Proteoglycan and Dislocations (Inserm)

Assistant Professor – Instructive Biomaterials Engineering (Maastricht University)

PhD Position – Tumor Biology (University of Duisburg-Essen)

Postdoctoral Fellow – Disseminated Tumor Cell Biology (Fred Hutchinson Cancer Research Center)

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