Volume 5.32 | Aug 21

Newsletter Issue
Extracellular Matrix News 5.32 August 21, 2014
Extracellular Matrix News
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Multiscale Patterned Transplantable Stem Cell Patches for Bone Tissue Regeneration
Scientists approached a conceptual platform that can integrate stem cells into a multiscale patterned substrate for bone regeneration. Inspired by human bone tissue, they developed hierarchically micro- and nanopatterned transplantable patches as synthetic extracellular matrices by employing capillary force lithography in combination with a surface micro-wrinkling method using a poly(lactic-co-glycolic acid) polymer. [Biomaterials] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
β-Arrestins Regulate Human Cardiac Fibroblast Transformation and Collagen Synthesis in Adverse Ventricular Remodeling
Investigators hypothesized that β-arrestins play an important role in the regulation of adult human cardiac fibroblasts biology with regard to myofibroblast transformation, increased collagen synthesis, and myocardial fibrosis which are important in the development of heart failure. [J Mol Cell Cardiol] Abstract

Effect of FGF-2 on Collagen Tissue Regeneration by Human Vertebral Bone Marrow Stem Cells
The effects of fibroblast growth factor-2 (FGF-2) on collagen tissue regeneration by human bone marrow stem cells (hBMSCs) were investigated. The FGF-2 treatment affected the colony-forming efficiency, proliferation, and in vitro differentiation of hBMSCs. [Stem Cells Dev] Abstract

A Comparative Study on In Vitro Osteogenic Priming Potential of Electron Spun Scaffold PLLA/HA/Col, PLLA/HA, and PLLA/Col for Tissue Engineering Application
A comparative study on the in vitro osteogenic potential of electrospun poly-L-lactide/hydroxyapatite/collagen (PLLA/HA/Col, PLLA/HA, and PLLA/Col) scaffolds was conducted. Cell attachment, distribution, morphology, mineralization, extracellular matrix protein localization, and gene expression of human mesenchymal stromal cells differentiated on the fibrous scaffolds PLLA/Col/HA, PLLA/Col, and PLLA/HA were analyzed. [PLoS One] Full Article

Interplay between Cellular Activity and Three-Dimensional Scaffold-Cell Constructs with Different Foam Structure Processed by Electron Beam Melting
Scientists combined cellular biology and materials science and engineering to fundamentally elucidate the interplay between cellular activity and interconnected three-dimensional foamed architecture obtained by a novel process of electron beam melting and computational tools. Furthermore, the organization of key proteins, notably, actin, vinclulin, and fibronectin, involved in cellular activity and biological functions and relationship with the structure was explored. [J Biomed Mater Res A] Abstract

Resistance to Cigarette Smoke Is Increased in PDL Cells by Attachment to Collagen and Fibronectin
Researchers investigated the direct effects of smoking on periodontal ligament (PDL) fibroblasts, focusing on cell-extracellular matrix interactions and cell survival. [J Periodontol] Abstract

Gallic Acid Regulates Skin Photoaging in UVB-Exposed Fibroblast and Hairless Mice
The mechanisms underlying skin photoaging are closely associated with degradation of collagen via upregulation of matrix metalloproteinase activity, which is induced by reactive oxygen species production. Scientists investigated the protective effects of gallic acid against photoaging caused by ultraviolet B (UVB) irradiation using normal human dermal fibroblasts in vitro and hairless mice in vivo. [Phytother Res] Abstract

Epigalloccatechin-3-Gallate Inhibits Ocular Neovascularization and Vascular Permeability in Human Retinal Pigment Epithelial and Human Retinal Microvascular Endothelial Cells via Suppression of MMP-9 and VEGF Activation
Epigalloccatechin-3-gallate treatment significantly decreased mRNA and protein expression levels of matrix metalloproteinases-9 (MMP-9) in the presence of 12-O-tetradecanoylphorbol-13-acetate and tumor necrosis factor alpha in human retinal pigment epithelial cells. [Molecules] Abstract | Download Full Article

The Inhibitor of Kappa B Kinase-Epsilon Regulates MMP-3 Expression Levels and Can Promote Lung Metastasis
Matrix metalloproteinases (MMP) were identified as potential regulators of the site-specificity of metastasis. Researchers investigated signaling pathways regulating MMP-3 expression and the role that MMP-3 plays in lung metastasis. [Oncogenesis] Full Article

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In Vitro 3D Bone Tissue Models, from Cells to Controlled and Dynamic Environment
The authors focus on state of the art and the current advances in the development of 3-dimensional (3D) culture systems for bone biology research. They describe more specifically advantages related to the use of such systems, and detail main characteristics and challenges associated with its three main components, i.e. scaffold, cells and perfusion bioreactor systems. [Tissue Eng Part B Rev] Abstract

Post-Translational Modifications of Integrin Ligands as Pathogenic Mechanisms in Disease
Protein post-translational modifications like glycation, carbamylation and citrullination increase the functional diversity of the proteome but in disease situations might do more harm than good. Post-translational modifications of extracellular matrix proteins are thus appearing as mechanisms, which contribute to tissue dysfunction in chronic kidney disease, in diabetes and in various inflammatory diseases. [Matrix Biol] Full Article

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
‘Shape-Shifting’ Material Could Help Reconstruct Faces
Researchers report that they have developed a “self-fitting” material that expands with warm salt water to precisely fill bone defects, and also acts as a scaffold for new bone growth. [Press release from the American Chemical Society (ACS) discussing research presented at the 248th National Meeting & Exposition of the ACS, San Francisco] Press Release

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Professor Wins EMBS Early Career Achievement Award
Qi Wang recently won the prestigious 2014 Early Career Achievement Award from the IEEE Engineering in Medicine and Biology Society (EMBS). EMBS cited his “contribution to neural engineering and biomedical instrumentation, including measuring biomechanical properties of skin and tissue, building a tactile display for a virtual Braille system, and discovery of a neural basis for sensory adaptation in behavior.“ [Columbia University] Press Release

Tissue Development ‘Roadmap’ Created to Guide Stem Cell Medicine
Scientists have created a computer algorithm called CellNet as a “roadmap” for cell and tissue engineering to ensure that cells engineered in the lab have the same favorable properties as cells in our own bodies. [Wyss Institute for Biologically Inspired Engineering] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 21st Stem Cell Network Workshop – Bioengineering and Stem Cells
September 23, 2014
Sydney, Australia

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Postdoctoral Position – Proteases and Extracellular Matrix (GENYO)

PhD Position – Tissue Engineering and Stem Cell Biology (Dublin City University)

PhD Position – Biomaterials/Cartilage Regeneration (Peking University)

PhD Student – Bioengineering (George Mason University)

Postdoctoral Position – Neural Extracellular Matrix (German Center for Neurodegenerative Diseases)

Postdoctoral Fellow – Roles of Extracellular Matrix in Regulating the Response of Tissues to Injury (University of California – San Francisco)

Postdoctoral Research Associate – 3D Tissue Biology and Modeling (University of Zurich)

Research Associate – Embryonic Development and Repair of Basement Membranes (King’s College London)

Postdoctoral Fellow – Mechanisms that Contribute to Metastases of Breast Cancer Cells (Icahn School of Medicine at Mount Sinai)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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