Volume 4.39 | Oct 3

Extracellular Matrix News 4.39 October 3, 2013
Extracellular Matrix News
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The Regulation of Growth and Metabolism of Kidney Stem Cells with Regional Specificity Using Extracellular Matrix Derived from Kidney
The authors hypothesized that specialized bioengineered niches for stem cells can be established using extracellular matrix (ECM)-derived scaffolding materials. Kidney was selected as a model system because of the high regional diversification of renal tissue matrix. By preparing the ECM from three specialized regions of the kidney in three forms: intact sheets of decellularized ECM, ECM hydrogels, and solubilized ECM, they investigated how the structure and composition of ECM affect the function of kidney stem cells. [Biomaterials] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Chondroitin Sulfate Proteoglycans Potently Inhibit Invasion and Serve as a Central Organizer of the Brain Tumor Microenvironment
Glioblastoma is characterized by microscopic infiltration of tumor cells throughout the brain, whereas non-neural metastases, as well as select lower grade gliomas, develop as self-contained and clearly delineated lesions. Illustrated by rodent xenograft tumor models as well as pathological human patient specimens, researchers present evidence that one fundamental switch between these two distinct pathologies-invasion and noninvasion-is mediated through the tumor extracellular matrix. [J Neurosci] Full Article

Mouse Basophils Reside in Extracellular Matrix-Enriched Bone Marrow Niches which Control Their Motility
Basophils co-express FcεRIα and CD49b, the α-2 chain of integrin-type receptor VLA-2, which recognizes type-1 collagen as a major natural ligand. The physiological relevance of this integrin for interactions with extracellular bone marrow matrix remains unknown. Herein, researchers examined the expression of several receptors of this family by bone marrow-derived basophils sorted either ex-vivo or after culture with IL-3. [PLoS One] Abstract

Customized Biomimetic Scaffolds Created by Indirect Three-Dimensional Printing for Tissue Engineering
To create patient-specific scaffolds that match precisely to a patient’s external contours, scientists integrated our indirect 3DP technique with imaging technologies and successfully created custom scaffolds mimicking human mandibular condyle using polycaprolactone and chitosan for potential osteochondral tissue engineering. [Biofabrication] Abstract

Type-1 Pericytes Participate in Fibrous Tissue Deposition in Aged Skeletal Muscle
Transplantation studies in young animals indicate that type-2 pericytes are myogenic, while type-1 pericytes remain in the interstitial space. In older mice, however, the muscular regenerative capacity of type-2 pericytes is limited, and type-1 pericytes produce collagen, contributing to fibrous tissue deposition. [Am J Physiol Cell Physiol] Abstract

Complete Horizontal Skin Cell Resurfacing and Delayed Vertical Cell Infiltration into Porcine Reconstructive Tissue Matrix Compared to Bovine Collagen Matrix and Human Dermis
The authors used a human skin organ culture model to study whether porcine reconstructive tissue matrix is effective as a dermal tissue replacement. Skin cells or split-thickness skin grafts were seeded onto human deepidermized dermis, Strattice, and Matriderm. Cellular resurfacing and matrix infiltration were monitored by live fluorescence imaging, histology, and electron microscopy. [Plast Reconstr Surg] Abstract

Epicardial Infarct Repair with Basic Fibroblast Growth Factor-Enhanced CorMatrix-ECM Biomaterial Attenuates Postischemic Cardiac Remodeling
The authors propose a novel surgical procedure leveraging a commercially available extracellular matrix (ECM) biomaterial for the treatment of ischemic heart failure. Epicardial infarct repair using CorMatrix-ECM biomaterial patch was compared with sham in a rat myocardial infarction model. [J Thorac Cardiovasc Surg] Abstract

Injectable Small Intestine Submucosal Extracellular Matrix in an Acute Myocardial Infarction Model
The mechanisms involved in myocardial regeneration and cardiac remodeling were examined by injecting porcine-derived small intestine submucosal extracellular matrix, with and without circulating angiogenic cells, in a mouse model of acute myocardial infarction. [Ann Thorac Surg] Abstract

Curcumin Modulates Cannabinoid Receptors in Liver Fibrosis In Vivo and Inhibits Extracellular Matrix Expression in Hepatic Stellate Cells by Suppressing Cannabinoid Receptor Type-1 In Vitro
Investigators examined the curcumin effect on cannabinoid receptors (CBRs) system and its relevance to inhibition of extracellular matrix expression in hepatic stellate cells. Their in vivo data demonstrated that curcumin ameliorated fibrotic injury, and downregulated CBR1 but upregulated CBR2 at both mRNA and protein levels in rat fibrotic liver caused by carbon tetrachloride. [Eur J Pharmacol] Abstract

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Lumican Affects Tumor Cell Functions, Tumor-Extracellular Matrix Interactions, Angiogenesis and Inflammatory Response
This review critically discusses lumican’s roles in tumor development and progression. The authors will focus on correlating lumican’s expression and distribution in tumor tissues with: the organization of the tumor matrices; tumor cell signaling and functions; tumor cell-matrix interface; tumor angiogenesis; and lumican’s potential roles in tumor-associated inflammatory response. [Matrix Biol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

Stem Cell Society Singapore 2013 Symposium
Halozyme Presents PEGPH20 Phase Ib Clinical Trial Data
Halozyme Therapeutics, Inc. announced mature patient progression free survival and ongoing overall survival data from a Phase Ib trial of PEGylated Recombinant Human Hyaluronidase (PEGPH20) in combination with gemcitabine for the treatment of patients with stage IV metastatic pancreatic cancer. [Press release from Halozyme Therapeutics, Inc. discussing research presented at the European Cancer Congress 2013, Amsterdam] Abstract

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McGowan Institute Will Co-Direct $75 Million Second Phase of National Effort to Aid Wounded Warriors
The Armed Forces Institute for Regenerative Medicine will continue its efforts to apply the latest in tissue engineering and other regenerative medicine techniques to the treatment of battlefield injuries in a $75 million, five-year second phase. [UPMC] Press Release

Commercial Launch of Herceptin SC in EU Triggers Milestone Payment to Halozyme from Roche
Halozyme Therapeutics, Inc. announced that the commercial launch of Herceptin® SC in Europe has triggered a $10 million milestone payment to Halozyme under the License and Collaboration Agreement between Halozyme and Roche. This time-saving subcutaneous formulation of Herceptin using Halozyme’s recombinant human hyaluronidase received marketing authorization from the European Commission for the treatment of patients with HER2-positive breast cancer and was launched upon approval. [Halozyme Therapeutics, Inc.] Press Release
US Government Shuts Down
The US government entered a state of suspended animation on 1 October after Congress failed to agree on a budget for the next fiscal year, causing federal agencies – including those overseeing science policy and research – to shut down indefinitely. Most government scientists were ordered to stay at home, their offices and labs closed or run by a skeleton staff of ‘essential’ workers. The National Institutes of Health and the National Science Foundation stopped processing grants, some government websites were made inaccessible and many important research programmes were left hanging, potentially putting lives at risk in the case of some disease studies. [Nature Magazine] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Signal Transduction by Engineered Extracellular Matrices: Studying and Directing Cellular Function through Natural and Engineered Microenvironment
July 5-6, 2014
Waltham, United States

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Assistant Professor – Department of Cell Biology and Anatomy (Rosalind Franklin University of Medicine and Science)

NEW Postdoctoral Position – Pancreatic Cancer Biology and Experimental Therapeutics (Massachusetts General Hospital / Radiation Oncology)

Postdoctoral Position – Tissue Engineering (Weizmann Institute of Science)

PhD Position – Molecular Cell Biology (Weizmann Institute of Science)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Mesenchymal Cell Research (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

Quality Control Analyst – Media (STEMCELL Technologies Inc.)

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