Volume 3.12 | Mar 29

Extracellular Matrix News 3.12, March 29, 2012
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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Laminin/β1 Integrin Signal Triggers Axon Formation by Promoting Microtubule Assembly and Stabilization
Scientists show that extracellular matrix component laminin promotes neuronal polarization via regulating directional microtubule assembly through β1 integrin. [Cell Res] Abstract

Watch the Video: Superior Chondrogenic Differentiation Potential of MesenCult-XF cultured MSCs
PUBLICATIONS (Ranked by Impact Factor of the Journal)

Influence of Decellularized Matrix Derived from Human Mesenchymal Stem Cells on Their Proliferation, Migration and Multi-Lineage Differentiation Potential
This investigation aimed to characterize the biological nature and specificity of the influence of the mesenchymal
stem cell (MSC) extracellular matrix on MSCs. [Biomaterials] Abstract

Transglutaminase-2 Interaction with Heparin: Identification of a Heparin Binding Site that Regulates Cell Adhesion to Fibronectin-Transglutaminase-2 Matrix
Extracellular transglutaminase-2 binds heparan sulphate and has adhesive/signaling pro-fibrotic functions. Here, researchers investigated the molecular basis of this interaction. [J Biol Chem] Abstract

Synergistic Activity of αvβ3 Integrins and the Elastin Binding Protein Enhance Cell-Matrix Interactions on Bioactive Hydrogel Surfaces
Researchers utilized two different elastin mimetic peptide sequences to provide a template for extracellular matrix deposition when covalently incorporated into scaffold materials. [Biomacromolecules] Abstract

Modeling Neural Differentiation on Micropatterned Substrates Coated with Neural Matrix Components
By combining a photolithographic technique with use of neural extracellular matrix as a substrate, a biocompatible and efficient microenvironment for neuronal differentiation was developed. [Front Cell Neurosci] Abstract

Stress Relaxation of Swine Growth Plate in Semi-Confined Compression: Depth Dependent Tissue Deformational Behavior versus Extracellular Matrix Composition and Collagen Fiber Organization
Researchers hypothesized that tissue mechanical behavior in sub-regions of the growth plate is related to its collagen and proteoglycan content as well as its collagen fiber orientation. [Biomech Model Mechanobiol] Abstract

Electrospinning Adipose Tissue-Derived Extracellular Matrix for Adipose Stem Cell Culture
Scientists describe practical applications and purification of extracellular matrix from adipose tissue and its use in electrospinning scaffolds and adipose stem cell culture. [J Biomed Mater Res A] Abstract

Recellularization of Decellularized Human Adipose-Tissue-Derived Extracellular Matrix Sheets with Other Human Cell Types
Researchers decellularized human adipose tissue, fabricated a thin extracellular matrix (ECM) sheet and explored the potential of this human adipose-derived ECM sheet as a substrate to support the formation of tissues other than adipose tissue. [Cell Tissue Res] Abstract

Electrospun Bio-Composite P(LLA-CL)/Collagen I/Collagen III Scaffolds for Nerve Tissue Engineering
Poly (L-lactic acid)-co-poly(ε-caprolactone) or P(LLA-CL), collagen I and collagen III are utilized for the fabrication of nanofibers of different compositions and orientations by electrospinning. [J Biomed Mater Res B Appl Biomater] Abstract

Open Access JoVE Protocol: Discriminating NSCs from NPCs with the NeuroCult™ NCFC Assay


CorMatrix Adds John Davis as Executive Vice President of Sales and Marketing
CorMatrix Cardiovascular, Inc. announced that John Davis has been named executive vice president of sales and marketing. [PRNewswire] Press Release

Wellcome Trust to Launch £200 Million Investment Business for Healthcare and Life Sciences
The Board of Governors of the Wellcome Trust approved the creation of a new business that will invest in emerging businesses and technologies in the healthcare and life sciences sectors. [Wellcome Trust]
Press Release

UC San Diego, Taiwan’s Academia Sinica to Collaborate on Research
University of California (UC) San Diego and Taiwan’s Academia Sinica have agreed to collaborate across a broad range of research areas. [University of California, San Diego] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW Stem Cell Society Singapore (SCSS) Symposium 2012 – Stem Cell Based Therapy
September 6-7, 2012
Singapore, Singapore

Visit our events page to see a complete list of events in the extracellular matrix community.


Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

PhD and Postdoctoral Positions (Leibniz Institute for Neurobiology)

Postdoctoral Fellow – Cell Biology (Institute for Systems Biology)

Postdoctoral Fellow (Medical Research Council) 

Postdoctoral Position (Thomas Jefferson University)

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