Volume 11.24 | Jun 25

Extracellular Matrix News 11.24 | June 25 2020
Extracellular Matrix News by STEMCELL Technologies
Vol. 12.25 – 25 June, 2020
TOP STORY

Targeting the Hippo Pathway in Cancer, Fibrosis, Wound Healing and Regenerative Medicine

Researchers highlight the key findings from studies of Hippo pathway signaling across biological processes and diseases, and discuss new strategies and therapeutic implications of targeting this pathway.
[Nature Reviews Drug Discovery]

Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Bioactive‐Tissue‐Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing

A decellularized cardiac extracellular matrix‐based nanocomposite hydrogel was developed to provide superior mechanical stability, catheter injectability, retrievability, antibacterial properties, and biological activity to prevent recanalization.
[Advanced Materials]

Abstract

Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix

Direct co-culture with postnatal cardiac fibroblasts increased cardiomyocyte binucleation, which could be inhibited by RGD peptide treatment.
[Circulation Research]

Abstract

Metabolic Engineering against the Arginine Microenvironment Enhances CAR-T Cell Proliferation and Therapeutic Activity

Scientists demonstrated T cells could be re-engineered to express functional argininosuccinate synthase or ornithine transcarbamylase enzymes, in concert with different chimeric antigen receptors.
[Blood]

Abstract

Oncolytic Virus-Derived Type I Interferon Restricts CAR T Cell Therapy

Investigators tested whether the inflammatory nature of oncolytic viruses and their ability to remodel the tumor microenvironment may help to recruit and potentiate the functionality of CAR T cells.
[Nature Communications]

Full Article

Chronic Circadian Disruption Modulates Breast Cancer Stemness and Immune Microenvironment to Drive Metastasis in Mice

The authors observed that circadian disruption significantly increased cancer-cell dissemination and lung metastasis. It also enhanced the stemness and tumor-initiating potential of tumor cells and created an immunosuppressive shift in the tumor microenvironment.
[Nature Communications]

Full Article

Hydrogel-Based Milliwell Arrays for Standardized and Scalable Retinal Organoid Cultures

Investigators report a tissue-engineering approach to accelerate and standardize the production of retinal organoids by culturing mouse ESCs in optimal physico-chemical microenvironments.
[Scientific Reports]

Full Article

Transient Receptor Potential Vanilloid Channel Regulates Fibroblast Differentiation and Airway Remodeling by Modulating Redox Signals through NADPH Oxidase 4

Researchers identified that Transient Receptor Potential Vanilloid 4 (TRPV4), a mechanosensitive ion channel mediated lung fibroblast differentiation and D. farinae-induced airway remodeling via a novel TRPV4-NADPH Oxidase 4 interaction.
[Scientific Reports]

Full Article

Signaling Inhibitors Accelerate the Conversion of Mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment

Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
[Scientific Reports]

Full Article

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REVIEWS

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

The authors explore current strategies that shift immune cell metabolism to pro-inflammatory states in the tumor microenvironment and highlight a need to better replicate physiologic conditions to select targets, clarify mechanisms, and optimize metabolic inhibitors.
[Molecular Cell]

Abstract

Tumor-Induced Neurogenesis and Immune Evasion as Targets of Innovative Anti-Cancer Therapies

Scientists discuss the potential of anti-neurogenesis and, considering the interplay between nervous and immune systems, they also focus on anti-immunosuppression-based therapies.
[Signal Transduction and Targeted Therapy]

Full Article

INDUSTRY AND POLICY NEWS

Alteogen Enters into a Global License Agreement with a Top Ten Pharmaceutical Company for Use of Its Hybrozyme Technology to Enable Subcutaneous Administration of Biologic Products

[Alteogen, Inc.]

Press Release

Gender Gap in Research Output Widens During Pandemic

A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist]

Editorial

Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]

Editorial

FEATURED EVENT

International Society for Stem Cell Research (ISSCR): Advances in Stem Cell Research: From Single Cells to Organs

2020-10-12 – 2020-10-14
Paris, France

> See All Events

JOB OPPORTUNITIES

Postdoctoral Fellow Position – Primitive Collagen and Stem Cell Chondrogenesis

Drexel University – Philadelphia, Pennsylvania, United States

Postdoctoral Associate – Optic Nerve Head Extracellular Matrix Remodeling

University of Pittsburgh – Pittsburgh, Pennsylvania, United States

Department Chair – Bioengineering

The University of Washington – Seattle, Washington, United States

Senior Scientist – Developmental and Regenerative Biology

Icahn School of Medicine at Mount Sinai – New York City, New York, United States

Senior Researcher – Regenerative Biology

Genetech, Inc. – San Francisco, California, United States

> See All Jobs

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