Volume 11.23 | Jun 18

ECM 11.22 | June 18 2020
Extracellular Matrix News by STEMCELL Technologies
Vol. 11.23 – 18 June, 2020
TOP STORY

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

Intravenous delivery of immunity- and matrix-regulatory cells, derived from human embryonic stem cells, inhibited both pulmonary inflammation and fibrosis in mouse models of lung injury, and significantly improved the survival rate of the recipient mice in a dose-dependent manner, likely through paracrine regulatory mechanisms.
[Cell Research]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

LiQD Cornea: Pro-Regeneration Collagen Mimetics as Patches and Alternatives to Corneal Transplantation

The self-assembling, fully defined, synthetic collagen analog is much less costly than human recombinant collagen and reduced the risk of immune rejection associated with xenogeneic materials.
[Science Advances]

Full Article

3D Printed Deformable Sensors

The authors developed an in situ 3D printing system that estimated the motion and deformation of the target surface to adapt the toolpath in real time. With this printing system, a hydrogel-based sensor was printed on a porcine lung under respiration-induced deformation.
[Science Advances]

Full Article

Nanoparticle Delivery of Immunostimulatory Oligonucleotides Enhances Response to Checkpoint Inhibitor Therapeutics

Researchers found that their engineered nanoparticles carrying a CpG DNA ligand of TLR9 could suppress tumor growth in several animal models of various cancers, resulting in an abscopal effect on distant tumors, and improving responsiveness to anti-CTLA4 treatment with combinatorial effects after intratumoral administration.
[Proceedings of the National Academy of Sciences of the United States of America]

Full Article

Humidity‐Triggered Relaxation of Polyelectrolyte Complexes as a Robust Approach to Generate Extracellular Matrix Biomimetic Films

Scientists report a facile approach to generate ECM biomimetic films based on the humidity‐triggered relaxation of polyelectrolyte complex nanoparticles.
[Advanced Healthcare Materials]

Abstract

Simulating the Human Colorectal Cancer Microenvironment in 3D Tumor-Stroma Co-Cultures In Vitro and In Vivo

Researchers successfully converted three in-house-derived primed human PSC lines to a naive state and an expanded pluripotent stem cell (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
[Scientific Reports]

Full Article

Allosteric Communications between Domains Modulate the Activity of Matrix Metalloprotease-1

Investigators showed that communications between the catalytic and hemopexin domains of matrix metalloprotease-1 on type-1 collagen fibrils correlated with its activity.
[Biophysical Journal]

AbstractFull Article

Intercellular Adhesion Stiffness Moderates Cell Decoupling as a Function of Substrate Stiffness

Researchers modeled a three-dimensional cell pair on a patterned substrate, a simple laboratory setup to study intercellular interactions. They explicitly modeled focal adhesions and adherens junctions. These mechanosensing adhesions matured, becoming stabilized by force.
[Biophysical Journal]

Full Article

Neural Stem Cell Delivery via Porous Collagen Scaffolds Promotes Neuronal Differentiation and Locomotion Recovery in Spinal Cord Injury

Scientists demonstrated that grafts based on porous collagen-based scaffolds, similar to biomaterials utilized clinically in induced regeneration, could deliver and protect embryonic neural stem cells at spinal cord injury (SCI) sites, leading to significant improvement in locomotion recovery in an experimental mouse SCI model.
[NPJ Regenerative Medicine]

Full Article

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REVIEWS

Regulation of Heterogeneous Cancer-Associated Fibroblasts: The Molecular Pathology of Activated Signaling Pathways

Pro-inflammatory cytokines, such as leukemia inhibitory factor and interleukin-6, were secreted by both cancer cells and cancer associated fibroblasts (CAFs), and mediated the epigenetic modification of CAFs. This enhanced the pro-tumorigenic function of CAFs mediated by promoting actomyosin contractility and ECM remodeling to form the tracks used for collective cancer cell migration.
[Journal of Experimental & Clinical Cancer Research]

Full Article

INDUSTRY AND POLICY NEWS

Lassen Therapeutics Launches to Discover and Develop Novel Antibody Therapeutics Including Lead Program Targeting IL-11 to Treat Fibrosis and Oncology

Lassen Therapeutics announced it has emerged from stealth and secured $31 million in Series A financing to develop antibodies as potential treatments for fibrosis, rare diseases and oncology.
[Lassen Therapeutics]

Press Release

Bellicum Receives FDA IND Clearance to Initiate a Phase I/II Clinical Trial for BPX-603, a Dual-Switch GoCAR-T® for HER2+ Solid Tumors

Bellicum Pharmaceuticals, Inc. announced clearance by the FDA of its investigational new drug application for BPX-603. BPX-603 is a GoCAR-T® product candidate targeting solid tumors that express human epidermal growth factor receptor 2 (HER2).
[Bellicum Pharmaceuticals, Inc.]

Press Release

Hong Kong’s Contentious National Security Law Concerns Some Academics

China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
[Nature News]

Editorial

FEATURED EVENT

Myeloma and Plasma Cell Dyscrasias

2020-10-02 – 2020-10-05
Boston, Massachusetts, United States

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JOB OPPORTUNITIES

Postdoctoral Associate – Optic Nerve Head Extracellular Matrix Remodeling

University of Pittsburgh – Pittsburgh, Pennsylvania, United States

Department Chair – Bioengineering

The University of Washington – Seattle, Washington, United States

Senior Scientist – Developmental and Regenerative Biology

Icahn School of Medicine at Mount Sinai – New York City, New York, United States

Senior Researcher – Regenerative Biology

Genetech, Inc. – San Francisco, California, United States

Postdoctoral Fellow – Cancer Immunology

Emory University – Atlanta, Georgia, United States

Associate Professor – Cancer Biology

The Chinese University of Hong Kong – Hong Kong, China

Vice President – Oncology and Cell Therapy

GlaxoSmithKline – Stevenage, United Kingdom

Assistant Professor – Mammalian Synthetic Biology

Eindhoven University of Technology – Eindhoven, Netherlands

Researcher – Biomaterials Scientist

Aspect Biosystems – Vancouver, British Columbia, Canada

Research Scientist – Tumor Microenvironment

Systimmune, Inc. – Redmond, Washington, United States

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