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Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Blockade of TGF-β and PD-L1 by Bintrafusp Alfa Promotes Survival in Preclinical Ovarian Cancer Models by Promoting T Effector and NK Cell Responses
[British Journal Of Cancer] The authors tested whether coordinated blockade of TGF-β and PD-L1 with bintrafusp alfa could provoke anti-tumour immune responses in preclinical high-grade serous ovarian cancer models.
Federal Agency Supports Research to Improve Nanofiber Production
[Rowan University] A team of engineers from the Rowan-Virtua School of Translational Biomedical Engineering & Sciences and the Henry M. Rowan College of Engineering has developed novel technology for fabricating aligned nanofibers in continuous rolls of material.
Dynamic Molecular Network Analysis of iPSC-Purkinje Cells Differentiation Delineates Roles of ISG15 in SCA1 at the Earliest Stage
[Communications Biology] The authors investigated the earliest molecular pathology of spinocerebellar ataxia type 1 (SCA1), a rare familial neurodegenerative disease that primarily induces death and dysfunction of cerebellum Purkinje cells.
SBU Senior Nishtha Tripathi to Be Inducted Into Competitive ASBMB Honor Society
[At Bonaventure University] St. Bonaventure University senior Nishtha Tripathi of Austin, Texas, is among 31 undergraduate students nationwide who were accepted into the competitive American Society for Biochemistry and Molecular Biology Honor Society for 2024.
Sprouty Genes Regulate Activated Fibroblasts in Mammary Epithelial Development and Breast Cancer
[Cell Death & Disease] Investigators showed in mammary stromal fibroblasts that loss of the receptor tyrosine kinase (RTK) negative feedback regulators encoded by Spry1, Spry2, and Spry4 causes upregulation of signaling in multiple RTK pathways and increased extracellular matrix remodeling, resulting in accelerated epithelial branching.
Human Placenta Decellularized Extracellular Matrix Hydrogel Promotes the Generation of Human Spinal Cord Organoids with Dorsoventral Organization from Human Induced Pluripotent Stem Cells
[ACS Biomaterials Science & Engineering] The authors introduced a novel human decellularized placenta-derived extracellular matrix hydrogel and, combined with a new induction protocol, successfully construct human spinal cord organoids.
Mechanical State Transitions in the Regulation of Tissue Form and Function
[Nature Reviews Molecular Cell Biology] Scientists focus on the biological basis of tissue-scale mechanical state transitions, how they emerge from molecular and cellular interactions, and their roles in organismal development, homeostasis, regeneration and disease.
Induced Pluripotent Stem Cells in Cartilage Tissue Engineering: A Literature Review
[Bioscience Reports] A literature search was conducted using scientific search engines, PubMed, MEDLINE, and google scholar databases with the terms “Cartilage tissue engineering” and “ stem cells” to retrieve published literature on chondrogenic differentiation and tissue engineering using MSCs, ESCs, and hiPSCs.
SimuCell3D: Three-Dimensional Simulation of Tissue Mechanics with Cell Polarization
[Nature Computational Science] Researchers presented SimuCell3D, an efficient open-source program to simulate large tissues in three dimensions with subcellular resolution, growth, proliferation, extracellular matrix, fluid cavities, nuclei and non-uniform mechanical properties, as found in polarized epithelia.
Compensatory Growth and Recovery of Cartilage Cytoarchitecture after Transient Cell Death in Fetal Mouse Limbs
[Nature Communications] Investigators showed that transient sparse cell death in the mouse fetal cartilage was repaired postnatally, via a two-step process. During injury, progression of chondroprogenitors towards more differentiated states is delayed, leading to altered cartilage cytoarchitecture and impaired bone growth.
Expression Levels and DNA Methylation Profiles of the Growth Gene SHOX in Cartilage Tissues and Chondrocytes
[Scientific Reports] Microarray-based transcriptome analysis of the cartilage tissues of four adults and chondrocytes of 12 children showed that the median expression levels of SHOX, a growth gene in the pseudoautosomal region, were higher in male samples than in female samples.
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer
[Cancer Discovery] In immune-hot adenocarcinomas, spatial niches of T cells and macrophages increased with clonal neoantigen burden, whereas such an increase was observed for niches of plasma and B cells in immune-excluded squamous cell carcinomas
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
