Extracellular Matrix News

Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.

An Overview of Nasal Cartilage Bioprinting: From Bench to Bedside

[Journal Of Biomaterials Science-Polymer Edition] Although numerous studies have demonstrated the potential of 3D bioprinting in the rebuilding of such soft tissues, this paper covers various aspects of the bioprinted tissues to provide insights for the future development of repair techniques appropriate for clinical use.

Clay Sculpture-Inspired 3D Printed Microcage Module Using Bioadhesion Assembly for Specific-Shaped Tissue Vascularization and Regeneration

[Advanced Science] A novel approach is introduced to the construction of sizable tissue engineering grafts by employing hydrogel 3D printing for modular bioadhesion assembly, and a poly (ethylene glycol) diacrylate (PEGDA)-gelatin-dopamine hydrogel, photosensitive and adhesive, enabling fine microcage module fabrication via DLP 3D printing is developed.

Mast Cell Activation Disrupts Interactions Between Endothelial Cells and Pericytes During Early Life Allergic Asthma

[Journal Of Clinical Investigation] Using quantitative imaging in precision-cut lung slices, scientists reported that exposure of neonatal mice to house dust mite extract disrupted endothelial cell/pericyte interactions in adventitial areas.

N-Cadherin Dynamically Regulates Pediatric Glioma Cell Migration in Complex Environments

[Journal Of Cell Biology] The authors found that intercellular homotypic N-cadherin interactions differentially regulated glioma migration according to the microenvironment, stimulating migration on cultured neurons or astrocytes but inhibiting invasion into reconstituted or astrocyte-deposited ECM.

Biophysical Interplay between Extracellular Matrix Remodeling and Hypoxia Signaling in Regulating Cancer Metastasis

[Frontiers In Cell And Developmental Biology] Scientists summarize the role of biophysical interactions between cancer cells and their surroundings in determining cancer progression.

MLL1 Regulates Cytokine-Driven Cell Migration and Metastasis

[Science Advances] MLL1, with its scaffold protein Menin, controlled actin filament assembly via the IL-6/8/pSTAT3/Arp3 axis and myosin contractility via the TGF-β1/Gli2/ROCK1/2/pMLC2 axis, which together regulated dynamic protrusion generation and 3D cell migration.

DPM1 Modulates Desmosomal Adhesion and Epidermal Differentiation through SERPINB5

[Journal Of Cell Biology] In a 3D organotypic human epidermis model, loss of DPM1 caused impaired differentiation with abnormally increased cornification, reduced thickness of non-corneal layers, and formation of intercellular gaps in the epidermis.

New Canada Research Chairs Advance Research in Regenerative Medicine, Sustainable Housing, and More

[University of Toronto] New ways of growing human tissues outside the body, developed by Professor Alison McGuigan and her team, will help expand the ability of researchers to understand and control cell behavior.

Engineering a Heart Conduit: New $2M NIH Grant for Yale Research

[Yale School of Medicine] The National Institutes of Health (NIH) recently awarded Dr. Yibing Qyang, an associate professor of medicine and associate professor of biomedical engineering, and his colleagues in his laboratory a $2+ million R01 grant to support research to create an artificial blood vessel that can grow, pump, and resist infection and clotting.

Bioassembly of Hemoglobin-Loaded Photopolymerizable Spheroids Alleviates Hypoxia-Induced Cell Death

[Biofabrication] The authors developed an oxygen delivering system relying on natural-derived components which are cytocompatible, allow for photopolymerization and advanced biofabrication processes, and improve cell survivability under hypoxia.

Cancer-Associated Fibroblasts Produce Matrix-Bound Vesicles That Influence Endothelial Cell Function

[Science Signaling] Using human mammary cancer-associated fibroblasts (CAFs), investigators showed that CAFs with a myofibroblast phenotype released extracellular vesicles that transferred proteins to endothelial cells that affected their interaction with immune cells.

The HIF-1α/PLOD2 Axis Integrates Extracellular Matrix Organization and Cell Metabolism Leading to Aberrant Musculoskeletal Repair Disease

[Bone Research] Using single-cell RNA sequencing and spatial transcriptomics analyses of the heterotopic ossification site, investigators found that collagen ECM organization is the most highly up-regulated biological process in mesenchymal progenitor cells.

The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.

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