Volume 7.19 | May 19

Extracellular Matrix News 7.19 May 19, 2016
Extracellular Matrix News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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Investigation of Migration and Differentiation of Human Mesenchymal Stem Cells on Five-Layered Collagenous Electrospun Scaffold Mimicking Native Cartilage Structure
In this study, a structured, multilayered collagen scaffold designed for the replacement of damaged cartilage is presented that allows repopulation by host cells and synthesis of a new natural matrix. [Adv Healthc Mater] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
TGF-β Signaling Regulates Cementum Formation through Osterix Expression
To define the functional relevance of the autonomous requirement for TGF-β signaling in mouse tooth development, scientists analyzed osteocalcin-Cre mediated Tgfbr2 conditional knockout mice, which lacks functional TGF-β receptor II in differentiating cementoblasts and cementocytes. [Sci Rep] Full Article

Endothelial Monolayers on Collagen-Coated Nanofibrous Membranes: Cell–Cell and Cell–ECM Interactions
Scientists described polycaprolactone nanofibrous membranes coated with collagen gel that overcome many limitations of conventional nanofibers used for engineering endothelia. They investigated cell–cell and cell–extracellular matrix (ECM) junctional complexes using collagen-coated and conventional nanofibrous membranes. [Biofabrication] Abstract

Regulation of Cellular Behaviors of Fibroblasts Related to Wound Healing by Sol-Gel Derived Bioactive Glass Particles
Results on the expression of extracellular matrix (ECM) related genes illustrated that 90S bioactive glass particles modulated the synthesis capacity for critical ECM molecules including type I collagen, type III collagen, fibronectin and tenascin-C. [J Biomed Mater Res A] Abstract

Transient Expression of the Diseased Phenotype of Osteoarthritic Chondrocytes in Engineered Cartilage
Chondrocytes isolated from either post-traumatic osteoarthritis or normal cartilage of canine knee joints were used to form micropellets to assess the maintenance of the osteoarthritic chondrocyte phenotype in vitro. [J Orthop Res] Abstract

Extracellular Matrix-Based Cryogels for Cartilage Tissue Engineering
Researchers investigated various highly porous extracellular matrix-based cryogels for cartilage tissue engineering. [Int J Biol Macromol] Abstract | Graphical Abstract

In Vivo Evaluation of Hybrid Patches Composed of PLA Based Copolymers and Collagen/Chondroitin Sulfate for Ligament Tissue Regeneration
The authors aimed to develop new hybrid patches for ligament tissue regeneration by synergistic incorporation of a knitted structure of degradable polymer fibers to provide mechanical strength and a biomimetic matrix to help injured tissues regeneration. [J Biomed Mater Res B Appl Biomater] Abstract

Fabrication and Development of Artificial Osteochondral Constructs Based on Cancellous Bone/Hydrogel Hybrid Scaffold
Porcine cancellous bones and chitosan/gelatin hydrogel scaffolds were used as substitutes to mimic bone and cartilage, respectively. The porosity and distribution of pore size in porcine bone was measured and the degradation ratio and swelling ratio for chitosan/gelatin hydrogel scaffolds was also determined in vitro. [J Mater Sci Mater Med] Abstract

Is Transcatheter Aortic Valve Implantation of Living Tissue-Engineered Valves Feasible? An In Vitro Evaluation Utilizing a Decellularized and Reseeded Biohybrid Valve
The influence of transcatheter aortic valve implantation procedure on tissue-engineered biohybrid aortic valve (BAV) was investigated. BAV were designed with decellularized homograft cusps and polyurethane walls. They were seeded with fibroblasts and endothelial cells isolated from saphenous veins. [Artif Organs] Abstract

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Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological Conditions
The authors summarize the recent advances in understanding the role of matrix metalloproteinases in physiological and pathological conditions. [J Cell Physiol] Abstract

The Role of Integrins in Glaucoma
The authors discuss the role of integrins and bidirectional signaling as they relate to the glaucomatous phenotype with special emphasis on the αvβ3 integrin. They present evidence that this particular integrin may have a significant impact on the pathogenesis of glaucoma. [Exp Eye Res] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Humacyte Commences Phase III Clinical Trial of Human Acellular Vessel
Humacyte announced the commencement of a Phase III study of HUMACYL®, its investigational human acellular vessel, as a conduit for hemodialysis in patients with End-Stage Renal Disease requiring renal replacement therapy and who are not candidates for fistula. [Humacyte, Inc.] Press Release

Biostage Successfully Regenerates Esophagus in Groundbreaking Pre-Clinical Work with Mayo Clinic; Data Provides ‘Proof of Concept’ to Seek FDA Approval for Clinical Trials
Biostage, Inc. announced significant, pre-clinical data, including the complete regeneration of a segment of the esophagus, from its collaborative large-animal study of its Cellspan™ organ implants with Mayo Clinic. [Biostage, Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 28th European Organisation for Research and Treatment of Cancer (EORTC), the National Cancer Institute (NCI) and the American Association for Cancer Research (AACR) SYMPOSIUM
November 29-December 2, 2016
Munich, Germany

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Scientific Communications and Publishing Coordinator (STEMCELL Technologies Inc.)

NEW Postdoctoral Position – Vascular Remodeling (Scripps Research Institute)

NEW Postdoctoral Position – Biomechanics (Massachusetts General Hospital & Harvard Medical School)

Postdoctoral Fellow – Genome Editing for Striated Muscle Regeneration (Duke University)

MSc Position – Extracellular Matrix Genes during Aging (ETH Zurich)

PhD Position – Extracellular Matrix Genes during Aging (ETH Zurich)

Postdoctoral Position – Extracellular Matrix Genes during Aging (ETH Zurich)

Postdoctoral Position – Motor Plasticity and Repair (Burke Medical Research Institute)

Postdoctoral Position – Cancer Biology/Immunology (The University of Texas MD Anderson Cancer Center)

Postdoctoral Fellow – Cervical Extracellular Matrix (University of Texas Southwestern Medical Center)

Postdoctoral Position – Stem Cell Biology and Tissue Engineering (Northwestern University)

Postdoctoral Position – Non-Viral Gene Delivery & Scaffold Design (Nanyang Technological University)

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