Surface-Driven Collagen Self-Assembly Affects Early Osteogenic Stem Cell Signaling
The authors report how extracellular matrix ligand self-assembly on biomaterial surfaces and the resulting nanoscale architecture can drive stem cell behavior. Cellular and molecular investigations with human bone marrow stromal cells revealed higher osteogenic differentiation and upregulation of focal adhesion-related components on smooth collagen layer coated substrates. [Adv Healthc Mater] Abstract
αv Integrins: Key Regulators of Tissue Fibrosis
Scientists discuss the current knowledge of the mechanisms of αv-integrin-mediated regulation of fibrogenesis and show that the therapeutic targeting of specific αv integrins represents a promising avenue to treat patients with a broad range of fibrotic diseases. [Cell Tissue Res] Full Article
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