Volume 7.11 | Mar 24

Extracellular Matrix News 7.11 March 24, 2016
Extracellular Matrix News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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Individualized Cancer Treatment Targeting the Tumor, Not the Whole Body, a Step Closer
They look like small, translucent gems but these tiny ‘gel’ slivers hold the world of a patient’s tumor in microcosm ready for trials of anti-cancer drugs to find the best match between treatment and tumor. The ‘gel’ is a new 3D printable material that opens the way to rapid, personalized cancer treatment by enabling multiple, simultaneous tests to find the correct therapy to target a particular tumor. [Press release from Queensland University of Technology discussing online prepublication in Nature Protocols] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Collagen-Rich Stroma in Aggressive Colon Tumors Induces Mesenchymal Gene Expression and Tumor Cell Invasion
Investigators found that collagen-I dominates the extracellular matrix in aggressive colon cancer. Mimicking the tumor microenvironment by replacing laminin-rich Matrigel with collagen-I was sufficient to induce tumor-specific mesenchymal gene expression, suppression of hepatocyte nuclear factor 4α and its target genes, and collective tumor cell invasion of patient-derived colon tumor organoids. [Oncogene] Abstract

Identification of a Novel Agrin-Dependent Pathway in Cell Signaling and Adhesion within the Erythroid Niche
Researchers identified the proteoglycan agrin as a novel regulator of Eph receptor signaling and characterized a novel mechanism controlling cell–cell adhesion and red cell development within the erythroid niche. [Cell Death Differ] Full Article

Perlecan Expression Influences the Keratin 15-Positive Cell Population Fate in the Epidermis of Aging Skin
Investigators found that perlecan expression decreased during chronological skin aging. Their in vitro studies revealed reduced perlecan transcript levels in aged keratinocytes. [Aging-US] Full Article

Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produce Matrices with Increased Stiffness and Collagen Content
Since altered matrix production influences tissue quality, and myofibroblasts are involved in normal and pathological soft tissue repair processes, researchers evaluated matrix production of cells derived from pre- and post-menopausal pelvic organ prolapse (POP) and non-POP control anterior vaginal wall tissues. [Sci Rep] Full Article

Substrate Engagement of Integrins α5β1 and αvβ3 Is Necessary, but Not Sufficient, for High Directional Persistence in Migration on Fibronectin
Scientists characterized fibroblast adhesion and migration on the extracellular matrix glycoproteins fibronectin and vitronectin, focusing on the role of α5β1 and αvβ3 integrins. [Sci Rep] Full Article

Long Noncoding RNAs Expressed in Human Hepatic Stellate Cells Form Networks with Extracellular Matrix Proteins
The authors identified over 3600 long noncoding RNAs that are expressed in human hepatic stellate cell myofibroblasts. Many are regulated by transforming growth factor beta, a major fibrotic signal, and form networks with genes encoding key components of the extracellular matrix, which is the substrate of the fibrotic scar. [Genome Med] Full Article

Impact of Elastin Incorporation into Electrochemically Aligned Collagen Fibers on Mechanical Properties and Smooth Muscle Cell Phenotype
Based on the principles of isoelectric focusing, two different types of elastin (soluble and insoluble) were incorporated into highly oriented electrochemically aligned collagen (ELAC) fibers and the effect of elastin incorporation on the mechanical properties of the ELAC fibers and smooth muscle cell phenotype was investigated. [Biomed Mater] Abstract

The Three Dimensional Microstructural Network of Elastin, Collagen and Cells in Achilles Tendons
Researchers hypothesized the elastic fibers, as another fibrillar component in the extracellular matrix, have a unique role in mechanical functions and microstructural arrangement in Achilles tendons. Using confocal and second harmonic generation imaging techniques, they examined the three-dimensional microstructure of the collagen, elastin and cells in the mid-portion of hydrated rabbit Achilles tendons. [J Orthop Res] Abstract

Collagen Matrix Remodeling in Stented Pulmonary Arteries after Transapical Heart Valve Replacement
Scientists investigated the impact of the stent on matrix remodeling of the pulmonary artery in a sheep model, focusing on matrix composition and collagen (re)orientation of the host tissue. [Cells Tissues Organs] Abstract

Inhibitors of RGD-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice
Pancreatic tissues of mice expressed mRNAs encoding subunits of Arg-Gly-Asp (RGD)-binding integrins. Cerulein administration increased expression of these integrins, altered pancreatic cell morphology and induced fibrosis. [Cell Mol Gastroenterol Hepatol] Abstract | Press Release

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Targeting Metastasis
Instead of being autonomous, tumor cells engage in bidirectional interactions with metastatic microenvironments to alter antitumor immunity, the extracellular milieu, genomic stability, survival signaling, chemotherapeutic resistance and proliferative cycles. In this review preclinical research, combination therapies and clinical trial designs are re-examined. [Nat Rev Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Fujifilm Achieves Major Improvements in Bone Regeneration Capability through Transplants of the Matrix to Areas of Bone Defect
Fujifilm Corporation has succeeded in significantly improving bone regeneration capability through the transplantation, to areas of defect in the calvarial bone of rats, of cellnest™ recombinant peptide based on human collagen type I, an extracellular matrix required for the cell cultures used in regenerative medicine. [Press release from Fujifilm Corporation discussing research presented at the 15th Congress of the Japanese Society for Regenerative Medicine, Osaka] Press Release

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ACell®, Inc. Receives FDA Clearance for Concurrent Use of Its Wound Management Devices
ACell, Inc. announced that it has received additional FDA clearance for its MicroMatrix® device, which describes the concurrent use of MicroMatrix® in conjunction with Cytal™ Wound Matrix or Cytal Burn Matrix devices. [ACell, Inc.] Press Release

CorMatrix® Cardiovascular, Inc. Treats First Patient in Its US Clinical Study for CorMatrix® ECM® Tricuspid Valve
CorMatrix Cardiovascular, Inc. announced treatment of the first patient to receive their tissue engineered regenerative CorMatrix® ECM® Tricuspid Valve. The company received approval for the CorMatrix® ECM® Tricuspid Heart Valve as an early feasibility study approved through the FDA Investigational Device Exemption. [CorMatrix® Cardiovascular, Inc.] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 10th World Biomaterials Congress
May 17-22, 2016
Montreal, Canada

NEW 2nd Matrix Biology Europe (MBE) Conference
June 11-14, 2016
Athens, Greece

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Postdoctoral Position – Non-Viral Gene Delivery & Scaffold Design (Nanyang Technological University)

Associate Director for Research (Georgia Institute of Technology)

PhD Student – Extracellular Matrix Proteins in Zebrafish Fin Regeneration (TU Dresden)

Professor – Chemical and Biomedical Engineering (Nanyang Technological University)

Postdoctoral Researcher – Cell Biology and Regenerative Therapies in Cardiovascular Diseases (Universitätsmedizin Göttingen)

Faculty Position – Bioengineering (Caltech)

Postdoctoral Positions – Human Stem Cells and Heart Regenerative Medicine (University of Pittsburgh)

PhD Positions – Cancer, Microbiology and Stem Cell Engineering (Virginia Commonwealth University)

PhD Positions – Tendon Repair and Regeneration (NUI Galway)

Postdoctoral Position – Nanobiotechnology (University of Notre Dame)

Postdoctoral Position – Neurology, Pediatrics, and Genetics (Icahn School of Medicine at Mount Sinai)

Research Fellow – Biomedical Engineering (Nanyang Technological University)

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