Volume 7.09 | Mar 10

Extracellular Matrix News 7.09 March 10, 2016
Extracellular Matrix News
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‘Person-on-a-Chip’ — Engineers Create Lab-Grown Heart and Liver Tissue for Drug Testing and More
Scientists have developed a new way of growing realistic human tissues outside the body. They have developed unique methods for manufacturing small, intricate scaffolds for individual cells to grow on. These artificial environments produce cells and tissues that resemble the real thing more closely than those grown lying flat in a petri dish. [Press release from the University of Toronto discussing online publication in Nature Materials] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
β3 Integrin-Mediated Spreading Induced by Matrix-Bound BMP-2 Controls Smad Signaling in a Stiffness-Independent Manner
Researchers showed that matrix-bound BMP-2 is sufficient to induce β3 integrin–dependent C2C12 cell spreading by overriding the soft signal of the biomaterial and impacting actin organization and adhesion site dynamics. [J Cell Biol] Abstract

Three-Dimensional Bioprinting of Thick Vascularized Tissues
Investigators report a method for bioprinting 3D cell-laden, vascularized tissues that exceed 1 cm in thickness and can be perfused on chip for long time periods. They integrated parenchyma, stroma, and endothelium into a single thick tissue by coprinting multiple inks composed of human mesenchymal stem cells and human neonatal dermal fibroblasts within a customized extracellular matrix alongside embedded vasculature. [Proc Natl Acad Sci USA] Abstract | Full Article | Press Release | Video

The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis
To investigate how elevated stromal initiator methionine tRNA (tRNAiMet) contributes to tumor progression, scientists generated a mouse expressing additional copies of the tRNAiMet gene (2+tRNAiMet mouse). Extracellular matrix deposited by fibroblasts from 2+tRNAiMet mice supported enhanced endothelial cell and fibroblast migration. [Curr Biol] Abstract | Press Release

Inhibition of FAK Signaling by Integrin α6β1 Supports Human Pluripotent Stem Cell Self-Renewal
Scientists describe a signaling pathway in human pluripotent stem cells (hPSCs) linking self-renewal and expression of pluripotency transcription factors to integrin α6β1 and inactivation of focal adhesion kinase (FAK). Disruption of this pathway results in hPSC differentiation. [Stem Cells] Abstract

Integrin-Linked Kinase Activity Modulates the Pro-Metastatic Behavior of Ovarian Cancer Cells
Investigators evaluated the expression and activity of integrin-linked kinase (ILK), a Ser/Thr protein kinase activated upon integrin-mediated adhesion. Results showed that ILK is co-expressed in epithelial ovarian cancer with the pro-metastatic enzyme membrane type 1 matrix metalloproteinase and catalyzed phosphorylation of the cytoplasmic tail of the proteinase. [Oncotarget] Full Article

The Synergistic Effects of Matrix Stiffness and Composition on the Response of Chondroprogenitor Cells in a 3D Precondensation Microenvironment
A biosynthetic hydrogel was developed containing RGD, hyaluronic acid and/or type-I collagen conjugated to poly(ethylene glycol) acrylate to recapitulate the precondensation microenvironment of the developing limb. Cell proliferation in these 3D matrices for 7 days prior to chondrogenic induction increased the rate of sGAG production in a stiffness-dependent manner. [Adv Healthc Mater] Abstract

Decellularized Extracellular Matrix Microparticles as a Vehicle for Cellular Delivery in a Model of Anastomosis Healing
Decellularized porcine peritoneum was mechanically dissociated into 200 µm microparticles, seeded with fibroblasts and cultured in a low gravity rotating bioreactor. The cells avidly attached and maintained excellent viability on the microparticles. When the seeded microparticles were placed in a collagen gel, the cells quickly migrated off the microparticles and through the gel. [J Biomed Mater Res A] Abstract

Mitogen-Activated Protein Kinase Signaling Causes Malignant Melanoma Cells to Differentially Alter Extracellular Matrix Biosynthesis to Promote Cell Survival
Researchers used 3D biomimetic platforms to understand dynamics in extracellular matrix (ECM) biogenesis following pharmaceutical intervention against mitogen-activated protein kinases signaling. They further determined temporal evolution of secreted ECM components by isogenic melanoma cell clones. [BMC Cancer] Full Article

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Taking Cues from the Extracellular Matrix to Design Bone-Mimetic Regenerative Scaffolds
The authors summarize research centered on the development of regenerative scaffolds that replicate the fundamental collagen-hydroxyapatite structure of native bone extracellular matrix, and the functionalization of these scaffolds with growth factors that stimulate critical events in osteogenesis. [Matrix Biol] Abstract

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Amedica and Celling Biosciences to Collaborate on Biologically Enhanced Spinal Fusion Devices
Amedica Corporation, a company that develops and commercializes silicon nitride ceramics as a biomaterial platform, announced a collaboration with Celling Biosciences, a leader in autologous cellular therapy technologies, to research and develop biologically enhanced implants. [Amedica Corporation] Press Release

$20 Million Gift Will Help Make Research Institute a Reality
An anonymous racehorse breeder has donated $20 million to Colorado State University to build a state-of-the-art regenerative medicine research facility, fulfilling a $65 million matching challenge from lead donors John and Leslie Malone. [Colorado State University] Press Release

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National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW World Stem Cells & Regenerative Medicine Congress
May 18-20, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW PhD Student – Extracellular Matrix Proteins in Zebrafish Fin Regeneration (TU Dresden)

NEW Professor – Chemical and Biomedical Engineering (Nanyang Technological University)

Postdoctoral Researcher – Cell Biology and Regenerative Therapies in Cardiovascular Diseases (Universitätsmedizin Göttingen)

Faculty Position – Bioengineering (Caltech)

Postdoctoral Positions – Human Stem Cells and Heart Regenerative Medicine (University of Pittsburgh)

PhD Positions – Cancer, Microbiology and Stem Cell Engineering (Virginia Commonwealth University)

PhD Positions – Tendon Repair and Regeneration (NUI Galway)

Postdoctoral Position – Nanobiotechnology (University of Notre Dame)

Postdoctoral Position – Neurology, Pediatrics, and Genetics (Icahn School of Medicine at Mount Sinai)

Research Fellow – Biomedical Engineering (Nanyang Technological University)

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