Volume 7.06 | Feb 18

Extracellular Matrix News 7.06 February 18, 2016
Extracellular Matrix News
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Scientists Prove Feasibility of “Printing” Replacement Tissue
Using a sophisticated, custom-designed 3D printer, scientists have proved that it is feasible to print living tissue structures to replace injured or diseased tissue in patients. [Press release from Wake Forest Baptist Medical Center discussing online publication in Nature Biotechnology] Press Release | Abstract
Development of Simplified and Defined Cell Culture for hPSCs - Watch Now!
PUBLICATIONS (Ranked by impact factor of the journal)
Extracellular Matrix Scaffolding Guides Lumen Elongation by Inducing Anisotropic Intercellular Mechanical Tension
Researchers demonstrated that the spatial scaffolding of cells by extracellular matrix can control tube shapes and can direct their elongation. They developed a minimal organ approach comprising of hepatocyte doublets cultured in artificial microniches to precisely control the spatial organization of cellular adhesions in three dimensions. [Nat Cell Biol] Abstract | Press Release

Cell-Free Multi-Layered Collagen-Based Scaffolds Demonstrate Layer Specific Regeneration of Functional Osteochondral Tissue in Caprine Joints
The long term ability of a multi-layered biomimetic collagen-based scaffold to repair osteochondral defects was investigated in a large animal model: namely critical sized lateral trochlear ridge and medial femoral condyle defects in the caprine stifle joint. [Biomaterials] Abstract

Extracellular Lumican Augments Cytotoxicity of Chemotherapy in Pancreatic Ductal Adenocarcinoma Cells via Autophagy Inhibition
Scientists investigated the role of extracellular lumican in chemotherapy-mediated cancer therapy. Lumican secretion was increased by chemotherapeutic agents in pancreatic ductal adenocarcinoma cells, and especially in pancreatic stellate cells, and appeared to be linked to the extent of cells’ response to chemotherapy-induced growth inhibition. [Oncogene] Abstract

Extracellular Matrix Microarrays to Study Inductive Signaling for Endoderm Specification
Using embryonic stem cells as a model system, investigators derived definitive endoderm progenitors and applied them to an extracellular matrix (ECM) array platform to study the influence of ECM, including the interactions of ECM with growth factor signaling, on the specification of definitive endoderm cells towards the liver and pancreas fates. [Acta Biomater] Abstract

ECM Microenvironment Unlocks Brown Adipogenic Potential of Adult Human Bone Marrow-Derived MSCs
Macromolecular crowding created a 3D extracellular matrix (ECM) architecture enshrouding maturing adipocytes in a collagen IV cocoon that was engaged by paxillin-positive focal adhesions also at the apical side of cells, without contact to the stiff support structure. [Sci Rep] Full Article

Extracellular Matrix Rigidity-Dependent Sphingosine-1-Phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion
The authors report that secretion of spingsine-1-phosphate and its regulator, SphK1 expression is dependent of the substrate rigidity, which is critical for the balance between cancer cell invasion and adhesion. [Sci Rep] Full Article

Proportion of Collagen Type II in the Extracellular Matrix Promotes the Differentiation of Human Adipose-Derived Mesenchymal Stem Cells into Nucleus Pulposus Cells
Human adipose-derived mesenchymal stem cells were cultured as a micromass or in a series of gradual proportion hydrogels of a mix of collagen types I and II. Cell proliferation and cytotoxicity were detected using CCK-8 and LDH assays respectively. [Biofactors] Abstract

Release of Matrix Metalloproteinases-2 and 9 by S-Nitrosylated Caveolin-1 Contributes to Degradation of Extracellular Matrix in tPA-Treated Hypoxic Endothelial Cells
Researchers report an important role of caveolin-1 s-nitrosylation in matrix metalloproteinase-2 and 9 secretion from tissue plasminogen activator (tPA)-treated ischemic endothelial cells. [PLoS One] Full Article

Odontogenic Differentiation of Human Dental Pulp Stem Cells on Hydrogel Scaffolds Derived from Decellularized Bone Extracellular Matrix and Collagen Type I
Researchers aimed to evaluate the level of odontogenic differentiation of dental pulp stem cells on hydrogel scaffolds derived from bone extracellular matrix (bECM) in comparison to those seeded on collagen I, one of the main components of dental pulp ECM. [PLoS One] Full Article

Mucin-Inspired Thermoresponsive Synthetic Hydrogels Induce Stasis in Human Pluripotent Stem Cells and Human Embryos
The authors report cellular stasis for both human pluripotent stem cell colonies and preimplantation embryos immersed in a wholly synthetic thermoresponsive gel comprising poly(glycerol monomethacrylate)-poly(2-hydroxypropyl methacrylate) diblock copolymer worms. [ACS Cent Sci] Full Article | Press Release

View Webinar: Genome Editing: From Modeling Disease to Novel Therapeutics
Fate Decision of Mesenchymal Stem Cells: Adipocytes or Osteoblasts?
The authors review external factors and their signaling processes dictating the reciprocal regulation between adipocytes and osteoblasts during mesenchymal stem cell differentiation and the ultimate control of the adipo-osteogenic balance. [Cell Death Differ] Full Article

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Stenting as Effective as Carotid Endarterectomy for Preventing Strokes in Asymptomatic Patients
The most modern clinical trial to compare the use of carotid-artery stenting with carotid endarterectomy for the prevention of strokes in asymptomatic patients with serious narrowing of the carotid artery found no significant differences in outcomes between the two procedures over a period of up to five years. [Press release from Massachusetts General Hospital discussing research presented at the International Stroke Conference (ISC) 2016, Houston] Press Release

From our sponsor: Learn about air-liquid interface culture for respiratory research. Watch the video.
UTA Researcher Earns NSF CAREER Grant to Develop Conductive Bioelastomers for More Effective, Safer Tissue Engineering
Yi Hong, an assistant professor of bioengineering, has won a five-year, $500,000 National Science Foundation (NSF) Early Career Development, or CAREER, Program grant to create conductive, single-component and biodegradable elastomers. [The University of Texas at Arlington] Press Release

Dr. William Fissell’s Artificial Kidney
Vanderbilt University Medical Center nephrologist and Associate Professor of Medicine Dr. William H. Fissell IV, is making major progress on a first-of-its kind device to free kidney patients from dialysis. He is building an implantable artificial kidney with microchip filters and living kidney cells that will be powered by a patient’s own heart. [Vanderbilt University] Press Release | Video
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Gordon Research Conference – Signaling by Adhesion Receptors
June 19-24, 2016
Lewiston, United States

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW PhD Positions – Cancer, Microbiology and Stem Cell Engineering (Virginia Commonwealth University)

NEW PhD Positions – Tendon Repair and Regeneration (NUI Galway)

Postdoctoral Fellow – Biomedical Engineering (University of Hull)

Postdoctoral Position – Nanobiotechnology (University of Notre Dame)

Field Application Engineer/Scientist – Single Cell Genomics (Berkeley Lights, Inc.)

Postdoctoral Position – Neurology, Pediatrics, and Genetics (Icahn School of Medicine at Mount Sinai)

Research Fellow – Biomedical Engineering (Nanyang Technological University)

Postdoctoral Positions – Physics and Engineering of Brain Imaging (Cardiff University)

Faculty Positions – Systems Biomedicine (Shanghai Jiao Tong University)

Postdoctoral Positions – Cancer Bioengineering and Biology (University of Minnesota)

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