Volume 7.04 | Feb 4

Extracellular Matrix News 7.04 February 4, 2016
Extracellular Matrix News
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Integrin Signaling Regulates the Expansion of Neuroepithelial Progenitors and Neurogenesis via Wnt7a and Decorin
Researchers showed that enhancing integrin beta-1 signaling, by expressing a constitutively active integrin beta-1 in the embryonic chick mesencephalon, enhances neurogenesis and increases the number of mitotic cells dividing away from the ventricular surface, analogous to sub-apical progenitors in mouse. [Nat Commun] Full Article
Weekend-Free Culture hPSCs with mTeSR™1 or TeSR™-E8™
PUBLICATIONS (Ranked by impact factor of the journal)
Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages
Scientists showed that epidermal Hedgehog and transforming growth factor-beta (TGF-β) signaling mediate the dermal changes. Epidermal Shh stimulates proliferation of the papillary fibroblast lineage, whereas TGF-β controls proliferation, differentiation and extracellular matrix production by reticular fibroblasts. [Nat Commun] Full Article

Polyclonal Breast Cancer Metastases Arise from Collective Dissemination of Keratin 14-Expressing Tumor Cell Clusters
Researchers used multicolor lineage tracing to demonstrate that polyclonal seeding by cell clusters is a frequent mechanism in a common mouse model of breast cancer, accounting for >90% of metastases. Intriguingly, locally disseminated clusters, circulating tumor cell clusters, and lung micrometastases frequently expressed the epithelial cytoskeletal protein, keratin 14. [Proc Natl Acad Sci USA]
Abstract | Press Release 1 | Press Release 2

The Development of a Tissue-Engineered Tracheobronchial Epithelial Model Using a Bilayered Collagen-Hyaluronate Scaffold
Investigators sought to engineer a bilayered collagen-hyaluronate scaffold for the development of a physiologically-representative 3D in vitro tracheobronchial epithelial co-culture model. [Biomaterials] Abstract

Alginate-Encapsulation for the Improved Hypothermic Preservation of Human Adipose-Derived Stem Cells
The authors present a simple, low-cost system capable of enhancing the preservation of human adipose-derived stem cells stored at hypothermic temperatures, while maintaining their normal function. [Stem Cells Transl Med] Abstract | Press Release

Matrix Metalloproteinase 12 Modulates High-Fat-Diet Induced Glomerular Fibrogenesis and Inflammation in a Mouse Model of Obesity
Scientists examined the function of matrix metalloproteinase-12 in glomerular fibrogenesis and inflammation using apo E−/− or apo E−/−MMP-12−/− mice and maintained on a high-fat-diet for three, six, or nine months. [Sci Rep] Full Article

The Extracellular Matrix Protein Laminin-10 Promotes Blood–Brain Barrier Repair after Hypoxia and Inflammation In Vitro
The authors investigated the mechanisms by which hypoxia and inflammation trigger loss of blood–brain barrier (BBB) integrity and tested the hypothesis extracellular matrix changes could contribute to BBB repair in vitro. [J Neuroinflammation] Full Article

A Titanium Surface with Nano-Ordered Spikes and Pores Enhances Human Dermal Fibroblastic Extracellular Matrix Production and Integration of Collagen Fibers
Investigators aimed to determine whether an alkali-heat treatment-created nano-topographic titanium surface could enhance human dermal fibroblastic functions and binding strength to the deposited collagen on the titanium surface. [Biomed Mater] Abstract

A New In Vitro Mouse Oligodendrocyte Precursor Cell Migration Assay Reveals a Role for Integrin-Linked Kinase in Cell Motility
Scientists developed a new oligodendrocyte precursor cell (OPC) migration method specifically suited for use with mouse-derived cells. They combined the new OPC migration assay with a conditional knockout approach to investigate the role of integrin-linked kinase in OPC migration. [BMC Neurosci] Full Article

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The Design of Reversible Hydrogels to Capture Extracellular Matrix Dynamics
To recapitulate the dynamic nature of the extracellular matrix, many reversible chemistries have been incorporated into hydrogels to regulate cell spreading, biochemical ligand presentation and matrix mechanics. [Nat Rev Mater] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

ASGCT 2016 Annual Meeting
Study on Use of Umbilical Cord vs. Biocellulose Film for Antenatal Spina Bifida Repair, Regenerative Patch May Improve Neurological Outcomes
Researchers presented findings from a study titled, “Cryopreserved Human Umbilical Cord vs. Biocellulose Film for Antenatal Spina Bifida Repair.” [Press release from the Society for Maternal-Fetal Medicine (SMFM) discussing research presented at the The Pregnancy Meeting™, Atlanta] Press Release

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Regenerative Medicine Awards Lay Groundwork for Therapies of Tomorrow
Two collaborative teams within USC Stem Cell are developing new approaches that could eventually help patients with heart disease, frontotemporal dementia and amyotrophic lateral sclerosis. Totaling $140,000 each, the awards support USC-affiliated faculty members pursuing multi-investigator research collaborations with the goal of curing diseases using stem cells as tools. [University of Southern California] Press Release

New Scaffold-Free 3-D Bioprinting Method Available for First Time in North America
Cell Applications, Inc. and Cyfuse Biomedical K.K. announced that advanced tissue-engineering services are now available in North America using a groundbreaking new three-dimensional (3D) bioprinting approach called the “Kenzan Method.” [Cell Applications, Inc. (EurekAlert!)] Press Release

CorMatrix Cardiovascular Secures Forty-One U.S. Patents in 2015 Including Additional Prosthetic Heart Valve Patents
CorMatrix® Cardiovascular, Inc. announced the issuance of U.S. Patent No. 9,226,821 relating to the company’s prosthetic heart valve platform. The prosthetic valves are comprised of extracellular matrix materials derived from multiple tissue sources, including, but not limited to, small intestine submucosa. [CorMatrix® Cardiovascular, Inc. (Business Wire)] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Gordon Research Conference – Musculoskeletal Biology & Bioengineering
August 7-12, 2016
Andover, United States

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Postdoctoral Position – Neurology, Pediatrics, and Genetics (Icahn School of Medicine at Mount Sinai)

NEW Research Fellow – Biomedical Engineering (Nanyang Technological University)

Postdoctoral Positions – Physics and Engineering of Brain Imaging (Cardiff University)

Scientist – Cell Biology (Semma Therapeutics)

Professor – Bioengineering (University of Illinois)

Postdoctoral Fellow – Stem Cell Biology/Genome Engineering (Amgen, Inc.)

Faculty Positions – Systems Biomedicine (Shanghai Jiao Tong University)

Postdoctoral Positions – Cancer Bioengineering and Biology (University of Minnesota)

Postdoctoral Fellow – Ophthalmology Research (University of California, San Francisco)

Postdoctoral Fellow – Interactions between Innate Immunity and Extracellular Matrix in Joint Diseases (Lund University)

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