Volume 6.49 | Dec 17

Extracellular Matrix News 6.49 December 17, 2015
Extracellular Matrix News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Long-Term Xeno-Free Culture of Human Pluripotent Stem Cells on Hydrogels with Optimal Elasticity
Scientists investigated human pluripotent stem cell (hPSC) cultures on biomaterials with different elasticities that were grafted with different nanosegments. The hPSCs cultured on the stiffest substrates tended to differentiate after five days of culture, whereas the hPSCs cultured on the optimal elastic substrates maintained their pluripotency for over 20 passages under xeno-free conditions. [Sci Rep] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Extracellular Matrix Fibronectin Initiates Endothelium-Dependent Arteriolar Dilation via the Heparin-Binding, Matricryptic RWRPK Sequence of FNIII1
Researchers tested the hypotheses that the matricryptic heparin-binding region of the first type III repeat of fibrillar fibronectin (FNIII1H) mediates vasodilation, and this response is endothelial cell-dependent. [J Physiol] Abstract

bFGF Binding Cardiac Extracellular Matrix Promotes the Repair Potential of Bone Marrow Mesenchymal Stem Cells in a Rabbit Model for Acute Myocardial Infarction
Investigators assessed the effect of basic fibroblast growth factor-binding extracellular matrix combined with bone marrow mesenchymal stem cells transplantation on acute myocardial infarction and explored the underlying mechanisms. [Biomed Mater] Abstract

Effects of the Scaffold Proteins Liprin-α1, β1 and β2 on Invasion by Breast Cancer Cells
Liprin-α1 promotes invasion by supporting the protrusive activity at the leading edge of the migrating tumor cell and the degradation of the extracellular matrix by invadopodia. Researchers addressed the role of liprin-α1 in the invasive process in vivo. [Biol Cell] Abstract

Effects of Mesenchymal Stem Cell Treatment on the Expression of Matrix Metalloproteinases and Angiogenesis during Ischemic Stroke Recovery
Scientists investigated the optimal time point of mesenchymal stem cell (MSC) transplantation. After MSC treatment, they also investigated the expression of matrix metalloproteinases, which play a role in vascular and tissue remodeling. [PLoS One] Full Article

Collagen Promotes Higher Adhesion, Survival and Proliferation of Mesenchymal Stem Cells
Researchers studied the effect of extracellular matrix proteins in controlling cell survival, proliferation, migration and directed mesenchymal stem cell differentiation. They found that collagen promoted cell proliferation, cell survival under stress and promoted high cell adhesion to the cell culture surface. [PLoS One] Full Article

In Vitro Evaluation of Decellularized ECM-Derived Surgical Scaffold Biomaterials
Scientists investigated scaffolds derived from dermis, small intestinal submucosa, and mesothelium and evaluated biological properties that modulate cellular responses and recruitment. An assay panel was utilized to assess the extracellular matrix (ECM) scaffold effects upon cells. [J Biomed Mater Res B Appl Biomater] Abstract

Direct E-Jet Printing of Three-Dimensional Fibrous Scaffold for Tendon Tissue Engineering
Investigators report the development of a novel electrohydrodynamic jet printing for engineering 3D tendon scaffold with high porosity and orientated micrometer-size fibers. [J Biomed Mater Res B Appl Biomater] Abstract

The Effects of High-Fat Feeding on Physical Function and Skeletal Muscle Extracellular Matrix
The authors demonstrated links between muscle extracellular matrix structure and physical function in obesity. [Nutr Diabetes] Full Article

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REVIEWS
The Interplay of Extracellular Matrix and Microbiome in Urothelial Bladder Cancer
Data suggest that both the extracellular matrix and the microbiota represent microenvironments that contribute to the onset and progression of tumours. Through the introduction of omics technologies and pyrosequencing analyses, a detailed investigation of these two microenvironments is now possible. [Nat Rev Urol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
 
SCIENCE NEWS
Celprogen Introduced Novel Small Molecules CEP2005 & CEP2010 that Activate and Stimulate Human Cardiac Stem Cells for Repair of Heart Tissue after a Cardiac Arrest
Celprogen Inc. announced that they have synthesized two small molecules that are able to activate the resident cardiac stem cell pool to accelerate cardiac repair after a cardiac arrest. The actual mechanism of action is not yet worked out, but the molecular recruitment of cardiac stem cells is well documented and established in their in-house 3D human cardiac cell culture models. [Press release from the Celprogen Inc. discussing research presented at the 2015 American Society for Cell Biology (ASCB) Annual Meeting, San Diego] Press Release

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INDUSTRY NEWS
Professor Helen Lu Wins $1.125 Million Grant on New Tissue Engineering Approach to Rotator Cuff Repair
Biomedical Engineering Professor Helen H. Lu has won a three-year $1.125 million Translational Research Award grant from the Department of Defense’s Congressionally Directed Medical Research Programs for her research on tendon-to-bone integration for rotator cuff repair. The funding will support preclinical trials to test the potential of a nanofiber-based device to enable biological healing between tendon and bone post rotator cuff surgery. [Columbia University] Press Release

New Center Focuses on Regenerative Medicine
A new center has been formed at Washington University School of Medicine in St. Louis to facilitate research that explores the regenerative properties of cells and tissues. The goal of the Center of Regenerative Medicine is to develop new medical treatments that might one day allow doctors to regrow or replace a damaged heart or severed nerves, or restore lost vision or hearing. [Washington University in St. Louis] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Gordon Research Seminar – Bioinspired Materials
June 4-5, 2016
Les Diablerets, Switzerland

Visit our events page to see a complete list of events in the extracellular matrix community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Ophthalmology Research (University of California, San Francisco)

Postdoctoral Fellow – Interactions between Innate Immunity and Extracellular Matrix in Joint Diseases (Lund University)

Postdoctoral Fellow – Statistical Analysis of Cell Migration (Karolinska Institutet)

PhD Position – Cancer Research and Wound Healing (Technion, Israel Institute of Technology)

Postdoctoral Position – Cell Mechanobiology (Washington University in St. Louis)

Research Associate – Cell Biology/Biophysics (University College London)

Postdoctoral Position – Scaffold Design & Drug/Gene Delivery for Neural Tissue Engineering (Nanyang Technological University)

Postdoctoral Position – Stem Cell Engineering Research (Nanyang Technological University)

Postdoctoral Position – hPSC-Derived Cardiomyocyte Grafts in Injured Hearts (University Health Network)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)


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