Long-Term Xeno-Free Culture of Human Pluripotent Stem Cells on Hydrogels with Optimal Elasticity
Scientists investigated human pluripotent stem cell (hPSC) cultures on biomaterials with different elasticities that were grafted with different nanosegments. The hPSCs cultured on the stiffest substrates tended to differentiate after five days of culture, whereas the hPSCs cultured on the optimal elastic substrates maintained their pluripotency for over 20 passages under xeno-free conditions. [Sci Rep] Full Article
Collagen Promotes Higher Adhesion, Survival and Proliferation of Mesenchymal Stem Cells
Researchers studied the effect of extracellular matrix proteins in controlling cell survival, proliferation, migration and directed mesenchymal stem cell differentiation. They found that collagen promoted cell proliferation, cell survival under stress and promoted high cell adhesion to the cell culture surface. [PLoS One] Full Article
In Vitro Evaluation of Decellularized ECM-Derived Surgical Scaffold Biomaterials
Scientists investigated scaffolds derived from dermis, small intestinal submucosa, and mesothelium and evaluated biological properties that modulate cellular responses and recruitment. An assay panel was utilized to assess the extracellular matrix (ECM) scaffold effects upon cells. [J Biomed Mater Res B Appl Biomater] Abstract
The Interplay of Extracellular Matrix and Microbiome in Urothelial Bladder Cancer
Data suggest that both the extracellular matrix and the microbiota represent microenvironments that contribute to the onset and progression of tumours. Through the introduction of omics technologies and pyrosequencing analyses, a detailed investigation of these two microenvironments is now possible. [Nat Rev Urol] Abstract
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SCIENCE NEWS
Celprogen Introduced Novel Small Molecules CEP2005 & CEP2010 that Activate and Stimulate Human Cardiac Stem Cells for Repair of Heart Tissue after a Cardiac Arrest
Celprogen Inc. announced that they have synthesized two small molecules that are able to activate the resident cardiac stem cell pool to accelerate cardiac repair after a cardiac arrest. The actual mechanism of action is not yet worked out, but the molecular recruitment of cardiac stem cells is well documented and established in their in-house 3D human cardiac cell culture models. [Press release from the Celprogen Inc. discussing research presented at the 2015 American Society for Cell Biology (ASCB) Annual Meeting, San Diego] Press Release
Professor Helen Lu Wins $1.125 Million Grant on New Tissue Engineering Approach to Rotator Cuff Repair
Biomedical Engineering Professor Helen H. Lu has won a three-year $1.125 million Translational Research Award grant from the Department of Defense’s Congressionally Directed Medical Research Programs for her research on tendon-to-bone integration for rotator cuff repair. The funding will support preclinical trials to test the potential of a nanofiber-based device to enable biological healing between tendon and bone post rotator cuff surgery. [Columbia University] Press Release
New Center Focuses on Regenerative Medicine
A new center has been formed at Washington University School of Medicine in St. Louis to facilitate research that explores the regenerative properties of cells and tissues. The goal of the Center of Regenerative Medicine is to develop new medical treatments that might one day allow doctors to regrow or replace a damaged heart or severed nerves, or restore lost vision or hearing. [Washington University in St. Louis] Press Release
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