Volume 6.42 | Oct 29

Extracellular Matrix News 6.42 October 29, 2015
Extracellular Matrix News
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Researchers Hack Off-the-Shelf 3-D Printer towards Rebuilding the Heart
Researchers have taken MRI images of coronary arteries and 3-D images of embryonic hearts and 3-D bioprint them with unprecedented resolution and quality out of very soft materials like collagens, alginates and fibrins. [Press release from Carnegie Mellon University discussing online prepublication in Science Advances] Press Release | Video | Abstract
NEW: Animal Component-Free MSC Chondrogenic Differentiation. Learn More.
PUBLICATIONS (Ranked by impact factor of the journal)
Integrin-Beta3 Clusters Recruit Clathrin-Mediated Endocytic Machinery in the Absence of Traction Force
Researchers found that force development at integrins regulates adaptor protein recruitment and endocytosis. Using mobile RGD (Arg-Gly-Asp) ligands on supported lipid membranes and rigid RGD ligands on glass, they found that matrix force-dependent integrin signals block endocytosis. [Nat Commun] Full Article

Bioengineering Human Myocardium on Native Extracellular Matrix
Scientists aimed to translate previous work to human scale and clinically relevant cells, for the bioengineering of functional myocardial tissue based on the combination of human cardiac matrix and human induced pluripotent stem cell-derived cardiomyocytes. [Circ Res] Abstract

Matrix Metalloproteinase 10 Degradomics in Keratinocytes and Epidermal Tissue Identifies Bioactive Substrates with Pleiotropic Functions
To better understand the role of matrix metalloproteinase 10 (MMP10) in the epidermis, investigators employed multiplexed iTRAQ-based Terminal Amine Isotopic Labeling of Substrates and monitored MMP10-dependent proteolysis over time in secretomes from keratinocytes. [Mol Cell Proteomics] Abstract

Abnormal Mechanosensing and Cofilin Activation Promote the Progression of Ascending Aortic Aneurysms in Mice
Investigators used comparative proteomics analysis of Fbln4SMKO aortas from postnatal day (P) 1 to P30 mice to identify key molecules involved in aneurysm initiation and expansion. At P14, the actin depolymerizing factor cofilin was dephosphorylated and thus activated, and at P7, the abundance of slingshot-1 phosphatase, an activator of cofilin, was increased, leading to actin cytoskeletal remodeling. [Sci Signal] Abstract

Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis
Researchers showed that transgenic mice expressing active renin from the liver (RenTgMK) developed progressive pulmonary fibrosis leading to impaired pulmonary function. Histological analyses revealed a marked increase in extracellular matrix (ECM) deposition and decrease in alveolar size in the lungs of RenTgMK mice compared to wild-type littermates, accompanied with increased expression of ECM proteins and fibrogenic factors. [Sci Rep] Full Article

Dickkopf-3 Regulates Prostate Epithelial Cell Acinar Morphogenesis and Prostate Cancer Cell Invasion by Limiting TGF-β-Dependent Activation of Matrix Metalloproteases
Investigators examined the effects of dickkopf-3 (Dkk-3) on the expression and activity of matrix metalloproteases, which mediate the effects of transforming growth factor (TGF)-β on extracellular matrix disassembly during tissue morphogenesis and promote invasion of tumor cells. [Carcinogenesis] Abstract

Interleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression
Scientists addressed whether interleukin-1 receptor antagonist (IL-1Ra) has a novel function in regulation of the extracellular matrix or adhesion molecules. Polymerase chain reaction array analysis demonstrated a ~5-fold increase in matrix metalloproteinase 13 mRNA expression of IL-1Ra siRNA-transfected Ca9-22 human oral squamous epithelial carcinoma cells compared with the control. [PLoS One] Full Article

Integrin β1 Gene Therapy Enhances In Vitro Creation of Tissue-Engineered Cartilage under Periodic Mechanical Stress
Researchers evaluated the effects of integrin β1 up-regulation on periodic mechanical stress-induced chondrocyte proliferation, matrix synthesis and ERK1/2 phosphorylation in chondrocyte monolayer culture, and evaluated the quality of tissue-engineered cartilage constructed in vitro under periodic mechanical stress combined with integrin β1 up-regulation. [Cell Physiol Biochem] Full Article

Nanofibrous Snake Venom Hemostat
Scientists describe a self-assembling nanofibrous peptide hydrogel (termed SLac) that on its own can act as a physical barrier to blood loss. In vitro evaluation of fibrin and whole blood clotting helped identify appropriate concentrations for hemostasis in vivo. [ACS Biomater Sci Eng] Abstract | Press Release

Development of Simplified and Defined Cell Culture for hPSCs - Watch Now!
Vascularization Mediated by Mesenchymal Stem Cells from Bone Marrow and Adipose Tissue: A Comparison
Investigators provide an overview and a comparison of the current knowledge of co-cultures of human endothelial cells with human adipose tissue-derived stem/stromal cells or bone marrow-mesenchymal stem cells in three dimensional hydrogel matrices. [Cell Regen] Full Article

Visit our reviews page to see a complete list of reviews in the Extracellular Matrix research field.
Cook Introduces Zenapro™ Hybrid Hernia Repair Device
Cook Biotech has designed and delivered to surgeons the first hernia-repair product that combines the tissue-remodeling properties and the patient-outcome benefits of a biologic graft with the strength of a large-pore synthetic mesh. [Cook Biotech, Inc.] Press Release

Symic Biomedical Advances First Product Candidate, SB-030, into Clinical Development with Treatment of First Patient in SHIELD Trial
Symic Biomedical, a clinical-stage biotherapeutics platform company developing compounds that target the extracellular matrix, announced the treatment of the first patient in its Phase I/II clinical study in humans to investigate the efficacy and safety of luminal SB-030 delivery in peripheral artery disease. [Symic Biomedical, Inc.] Press Release

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NEW Clinical Applications of Stem Cells
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Visit our events page to see a complete list of events in the Extracellular Matrix community.
NEW Postdoctoral Position – Scaffold Design & Drug/Gene Delivery for Neural Tissue Engineering (Nanyang Technological University)

NEW Postdoctoral Position – Stem Cell Engineering Research (Nanyang Technological University)

NEW Postdoctoral Position – hPSC-Derived Cardiomyocyte Grafts in Injured Hearts (University Health Network)

Faculty Position – Neuromuscular Bioengineering (Northwestern University)

Faculty Position – Stem Cells and Regenerative Medicine (King Abdullah University of Science and Technology)

Postdoctoral Position – Structural Studies of Bacterial Protein Secretion (University of Brussels)

Postdoctoral Position – Tissue Engineering and Regenerative Medicine (Northwestern University)

Postdoctoral Position – Biomaterials for Cell Reprogramming (Institute of Tissue Regeneration Engineering)

Director – Oncology Research (Novartis Institutes for BioMedical Research)

Director – Clinical Development (Novadip Biosciences)

Junior Faculty Position – Bioengineering (Stanford University)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

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