Volume 6.41 | Oct 22

Extracellular Matrix News 6.41 October 22, 2015
Extracellular Matrix News
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Tissue Matrix Arrays for High-Throughput Screening and Systems Analysis of Cell Function
Investigators spotted tissue extracellular matrix (ECM) particles as two-dimensional arrays or incorporated them with cells to generate three-dimensional cell-matrix microtissue arrays. They investigated the responses of human stem, cancer and immune cells to tissue ECM arrays originating from 11 different tissues. [Nat Methods] Abstract
View Webinar: Genome Editing: From Modeling Disease to Novel Therapeutics
PUBLICATIONS (Ranked by impact factor of the journal)
Definition of a Consensus Integrin Adhesome and Its Dynamics during Adhesion Complex Assembly and Disassembly
Researchers integrated several integrin adhesion complex (IAC) proteomes and generated a 2,412-protein integrin adhesome. Analysis of this data set revealed the functional diversity of proteins in IACs and established a consensus adhesome of 60 proteins. [Nat Cell Biol] Abstract

The Matrix Protein Fibulin-5 Is at the Interface of Tissue Stiffness and Inflammation in Fibrosis
Investigators showed that the loss of fibulin-5, an elastic fiber component, not only decreased tissue stiffness, but also diminished the inflammatory response and abrogated the fibrotic phenotype in a mouse model of cutaneous fibrosis. [Nat Commun] Full Article | Press Release

Improvement of Diaphragmatic Performance through Orthotopic Application of Decellularized Extracellular Matrix Patch
The authors demonstrated that orthotopic transplantation of a decellularized diaphragmatic muscle from wild animals promoted tissue functional recovery in an established atrophic mouse model. The extracellular matrix supported a local immunoresponse activating a pro-regenerative environment and stimulating host muscle progenitor cell activation and migration. [Biomaterials] Full Article

Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration
Scientists showed that fibronectin (FN) binding to α5β1 integrin triggered ubiquitination and internalization of the receptor complex. Acidification facilitated FN dissociation from integrin α5β1 in vitro and in early endosomes, promoting receptor complex deubiquitination by the USP9x and recycling to the cell surface. [Cell Rep] Full Article | Graphical Abstract

Carcinogenic Parasite Secretes Growth Factor that Accelerates Wound Healing and Potentially Promotes Neoplasia
Scientists showed that Opisthorchis viverrini secreted proteins accelerated wound resolution in human cholangiocytes, an outcome that was compromised following silencing of expression of the fluke-derived gene encoding the granulin-like growth factor, Ov-GRN-1. [PLoS Pathog] Full Article | Press Release

Novel Insights from 3D Models: The Pivotal Role of Physical Symmetry in Epithelial Organization
Investigators studied the mechanical environment created in two 3D models, the overlay protocol (OP) and embedded protocol (EP). Finite element analysis and active microrheology demonstrated that OP created a physically asymmetric environment with non-uniform mechanical stresses in radial and circumferential directions. Further contrasting with EP, acini in OP displayed cooperation between ErbB2 signaling and matrix crosslinking. [Sci Rep] Full Article

Bioprinting of Human Pluripotent Stem Cells and Their Directed Differentiation into Hepatocyte-Like Cells for the Generation of Mini-Livers in 3D
The authors report the first investigation into the bioprinting of human induced pluripotent stem cells, their response to a valve-based printing process as well as their post-printing differentiation into hepatocyte-like cells. [Biofabrication] Full Article | Press Release

Protease Inhibitors Enhance Extracellular Collagen Fibril Deposition in Human Mesenchymal Stem Cells
Researchers investigated the fate of collagen when it is in contact with mesenchymal stem cells and hypothesized that protease inhibition would enhance their extracellular deposition of collagen fibrils. [Stem Cell Res Ther] Full Article

Generation of Tissue-Engineered Small Intestine Using Embryonic Stem Cell-Derived Human Intestinal Organoids
Scientists investigated the ability of human embryonic stem cells or human intestinal organoids to populate acellular porcine intestinal matrices and artificial polyglycolic/poly L lactic acid scaffolds, and examined the ability of matrix/scaffolds to thrive when transplanted in vivo. [Biol Open] Full Article

Weekend-Free Culture hPSCs with mTeSR™1 or TeSR™-E8™
Vascular Diseases Await Translation of Blood Vessels Engineered from Stem Cells
The authors discuss current developments in the generation of vascular progenitor cells from human induced pluripotent stem cells (hiPSCs) and the assessment of their functional capacity in vivo, opportunities and challenges for the clinical translation of engineered vascular tissue, and modeling of vascular diseases using hiPSC-derived vascular progenitor cells. [Sci Transl Med] Abstract

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Activity Could Help Keep Knees Lubricated
Scientists at the University of Delaware have proposed a mechanism that explains how motion can cause cartilage to reabsorb synovial fluid that leaks out. [Press release from AVS Science and Technology of Materials, Interfaces, and Processing (Newswise, Inc.) discussing research to be presented at the AVS 62nd International Symposium and Exhibition, San Jose] Press Release

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$10 Million Award to Enable Trials for Heart Regeneration Program
A $10 million investment from the Washington Research Foundation will enable University of Washington Medicine scientists to begin clinical trials of a treatment that has the potential to restore heart tissue in people who have suffered heart attacks. [University of Washington Medicine] Press Release

Developing a Gel that Mimics Human Breast for Cancer Research
Scientists at the Universities of Manchester and Nottingham have been funded to develop a gel that will match many of the biological structures of human breast tissue, to advance cancer research and reduce animal testing. The £417,000 award from the National Centre for the Replacement, Refinement & Reduction of Animals in Research will be used to develop a gel, to incorporate many of the key features found in human breast tissue such as proteins and sugars from the matrix surrounding the breast cells. [University of Manchester] Press Release

UofL Researchers Awarded Patents for Innovations to Improve Cancer Treatments, Bone Grafts and Therapies for Spinal Cord Damage
Technologies to improve bone grafts and cancer immunotherapies, protect lung tissue during radiation treatment, reverse neurological damage and improve recovery from spinal cord injury are among the patents issued to the University of Louisville Research Foundation recently. [University of Louisville School of Medicine] Press Release
Researchers Examine Effects of Federal Recommendations on Cartilage Repair Studies in Large Animal Models
In recent years, scientists have focused on development of new treatments for cartilage repair. But in the past two decades there has been little to no adherence to the recommendations published by U.S. and European regulatory agencies on the manner in which translational research is conducted and reported in large animal models used to study cartilage repair. [Penn Medicine] Press Release | Abstract

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Gordon Research Conference – Craniofacial Morphogenesis & Tissue Regeneration
March 13-18, 2016
Ventura, United States

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NEW Faculty Position – Neuromuscular Bioengineering (Northwestern University)

Faculty Position – Stem Cells and Regenerative Medicine (King Abdullah University of Science and Technology)

Postdoctoral Position – Structural Studies of Bacterial Protein Secretion (University of Brussels)

Postdoctoral Position – Tissue Engineering and Regenerative Medicine (Northwestern University)

Postdoctoral Position – Biomaterials for Cell Reprogramming (Institute of Tissue Regeneration Engineering)

Director – Oncology Research (Novartis Institutes for BioMedical Research)

Director – Clinical Development (Novadip Biosciences)

Postdoctoral Position – Mechanisms of Leukocyte Extravasation (University Hospital of Münster)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Junior Faculty Position – Bioengineering (Stanford University)

Assistant Professor – Stem Cell Biology (Stanford University)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

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