Tissue Matrix Arrays for High-Throughput Screening and Systems Analysis of Cell Function
Investigators spotted tissue extracellular matrix (ECM) particles as two-dimensional arrays or incorporated them with cells to generate three-dimensional cell-matrix microtissue arrays. They investigated the responses of human stem, cancer and immune cells to tissue ECM arrays originating from 11 different tissues. [Nat Methods] Abstract
Novel Insights from 3D Models: The Pivotal Role of Physical Symmetry in Epithelial Organization
Investigators studied the mechanical environment created in two 3D models, the overlay protocol (OP) and embedded protocol (EP). Finite element analysis and active microrheology demonstrated that OP created a physically asymmetric environment with non-uniform mechanical stresses in radial and circumferential directions. Further contrasting with EP, acini in OP displayed cooperation between ErbB2 signaling and matrix crosslinking. [Sci Rep] Full Article
Vascular Diseases Await Translation of Blood Vessels Engineered from Stem Cells
The authors discuss current developments in the generation of vascular progenitor cells from human induced pluripotent stem cells (hiPSCs) and the assessment of their functional capacity in vivo, opportunities and challenges for the clinical translation of engineered vascular tissue, and modeling of vascular diseases using hiPSC-derived vascular progenitor cells. [Sci Transl Med] Abstract
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SCIENCE NEWS
Activity Could Help Keep Knees Lubricated
Scientists at the University of Delaware have proposed a mechanism that explains how motion can cause cartilage to reabsorb synovial fluid that leaks out. [Press release from AVS Science and Technology of Materials, Interfaces, and Processing (Newswise, Inc.) discussing research to be presented at the AVS 62nd International Symposium and Exhibition, San Jose] Press Release
$10 Million Award to Enable Trials for Heart Regeneration Program
A $10 million investment from the Washington Research Foundation will enable University of Washington Medicine scientists to begin clinical trials of a treatment that has the potential to restore heart tissue in people who have suffered heart attacks. [University of Washington Medicine] Press Release
Developing a Gel that Mimics Human Breast for Cancer Research
Scientists at the Universities of Manchester and Nottingham have been funded to develop a gel that will match many of the biological structures of human breast tissue, to advance cancer research and reduce animal testing. The £417,000 award from the National Centre for the Replacement, Refinement & Reduction of Animals in Research will be used to develop a gel, to incorporate many of the key features found in human breast tissue such as proteins and sugars from the matrix surrounding the breast cells. [University of Manchester] Press Release
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