Volume 6.29 | Jul 30

Extracellular Matrix News 6.29 July 30, 2015
Extracellular Matrix News
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Increased Protein Turnover Contributes to the Development of Pulmonary Fibrosis
Scientists have identified a new mechanism which contributes to the development of idiopathic pulmonary fibrosis. They showed that the pathological changes of lung tissue are accompanied by an increase in protein turnover by the central protein degradation machinery of the cell – the proteasome. [Press release from Helmholtz Zentrum München discussing online prepublication in American Journal of Respiratory and Critical Care Medicine] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Maspin Expression in Prostate Tumor Cells Averts Stemness and Stratifies Drug Sensitivity
To test the hypothesis that the tumor suppressor maspin may reduce microenvironment-dependent prostate tumor cell plasticity and thereby modulate drug sensitivity, scientists established a new schematic combination of 2D, 3D and suspension cultures to enrich prostate cancer cell subpopulations with distinct differentiation potentials. [Cancer Res] Abstract | Full Article

Rapidly Light-Activated Surgical Protein Glue Inspired by Mussel Adhesion and Insect Structural Crosslinking
The authors report a new light-activated, mussel protein-based bioadhesive (LAMBA) inspired by mussel adhesion and insect dityrosine crosslinking chemistry. LAMBA exhibited substantially stronger bulk wet tissue adhesion than commercially available fibrin glue and good biocompatibility in both in vitro and in vivo studies. [Biomaterials] Abstract | Press Release

Regulation of Sarcoma Cell Migration, Invasion and Invadopodia Formation by AFAP1L1 through a Phosphotyrosine-Dependent Pathway
The authors identified a novel pathway that directs Lyn/Src family tyrosine kinase signals to the invadopodia to regulate sarcoma cell invasion via the molecule AFAP-1-like-1 (AFAP1L1), a new member of the AFAP (actin filament-associated protein) family. They showed that AFAP1L1 can transform cells, promote migration and co-expression with active Lyn profoundly influences cell morphology and movement. [Oncogene] Abstract

Small Molecule and RNAi Induced Phenotype Transition of Expanded and Primary Colonic Epithelial Cells
Investigators report primary and prolonged culture of normal porcine epithelial cells from colon for cell line development. In addition, a novel primary three-dimensional intestinal culture system is presented, which generated organoids composed of a highly polarized epithelial layer lining a core of subepithelial tissue. [Sci Rep] Full Article

Transplantation of Neurons Derived from Human iPS Cells Cultured on Collagen Matrix into Guinea-Pig Cochleae
Neural stem cells were differentiated into neurons on a three-dimensional (3D) collagen matrix, using the same protocol of culture on Matrigel-coated plates; neuron subtypes in differentiated cells on a 3D collagen matrix were examined. [J Tissue Eng Regen Med] Abstract

αvβ3 Integrins Mediate Flow-Induced NF-κB Activation, Proinflammatory Gene Expression, and Early Atherogenic Inflammation
The authors sought to elucidate which integrin heterodimers mediate shear stress-induced endothelial cell activation and early atherogenesis. They showed that inhibiting αvβ3 integrins, but not α5β1 or αvβ5, blunted shear stress-induced proinflammatory signaling and gene expression. [Am J Pathol] Abstract

Matrix-Stiffness-Regulated Inverse Expression of Krüppel-Like Factor 5 and Krüppel-Like Factor 4 in the Pathogenesis of Renal Fibrosis
The proliferation of mouse proximal tubular epithelial cells in ex vivo culture depends on matrix stiffness. Combined analysis of the microarray and experimental data revealed that Krüppel-like factor (Klf)5 was the most up-regulated transcription factor accompanied by the down-regulation of Klf4 when cells were on stiff matrix. [Am J Pathol] Abstract

Targeted Type 2 Alveolar Cell Depletion Provides a Dynamic Functional Model for Lung Injury Repair
Researchers demonstrated that specific levels of type 2 alveolar epithelial cell (AEC2) depletion cause altered expression patterns of apoptosis and repair proteins in surviving AEC2 as well as distinct changes in distal lung morphology, pulmonary function, collagen deposition and expression of remodeling proteins in whole lung that persist for up to 60 days. [Am J Respir Cell Mol Biol] Abstract | Press Release

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation
Scientists aimed to determine the role of nicotinamide adenine dinucleotide phosphate oxidase (NOX)1 and NOX4 in liver fibrosis, and investigated whether NOX1 and NOX4 signaling mediates liver fibrosis by regulating hepatic stellate cells activation. [PLoS One] Full Article | Press Release

Impaired Extracellular Matrix Structure Resulting from Malnutrition in Ovariectomized Mature Rats
Biophysical, histological and molecular techniques were implemented to examine the underlying cellular and extracellular matrix changes and to assess the mechanisms contributing to bone loss in the context of aging and the widely used osteoporotic models in rats. [Histochem Cell Biol] Abstract

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Development and Application of Human Adult Stem or Progenitor Cell Organoids
The authors discuss the state-of-the-art of human adult stem or progenitor cell organoid culture and the potential of renal organoids as tools in basic and clinical research. [Nat Rev Nephrol] Abstract

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IBC’s Cell Therapy Bioprocessing & Commercialization meeting
University of Toronto to Transform Regenerative Medicine Thanks to Historic $114 Million Federal Grant
The University of Toronto is set to cement its position as one of the world’s leading centers for the design and manufacture of cells, tissues and organs that can be used to treat degenerative disease, thanks to a $114-million grant from the federal government. [University of Toronto] Press Release

Medtown Ventures, LLC Announces Exclusive License Agreement with Georgia Tech Research Corporation
Medtown Ventures, LLC announced that it has entered into an exclusive license agreement with Georgia Tech Research Corporation for a new adhesive-signature based stem cell selection and isolation technology. To focus on the commercialization of this new cell selection and isolation technology, Medtown has formed a new company, CellectCell™ Inc., with the inventors of the technology. [Medtown Ventures, LLC] Press Release

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW The 3rd International Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM)
October 22-24, 2015
Berlin, Germany

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NEW Assistant Professor – Cell-Based Therapies (Utrecht University)

Faculty Positions – Biomedical Engineering/Mechanical Engineering (University of California, Davis)

Scientific Writer – Cardiovascular Regeneration (Houston Methodist Research Institute)

Research Fellow – Tissue Engineering & Regenerative Medicine (National Cancer Centre Singapore)

Biomedical Engineer – Cell Therapies & Regenerative Medicine (FDA’s Center for Biologics Evaluation and Research)

PhD Position – Drug Releasing, Nanostructured Biomaterials for Adult Stem Cells (Karlsruhe Institute of Technology)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Postdoctoral Position – Proteoglycan and Dislocations (INSERM)

PhD Position – Tumor Biology (University of Duisburg-Essen)

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