Increased Protein Turnover Contributes to the Development of Pulmonary Fibrosis
Scientists have identified a new mechanism which contributes to the development of idiopathic pulmonary fibrosis. They showed that the pathological changes of lung tissue are accompanied by an increase in protein turnover by the central protein degradation machinery of the cell – the proteasome. [Press release from Helmholtz Zentrum München discussing online prepublication in American Journal of Respiratory and Critical Care Medicine] Press Release|Abstract
Maspin Expression in Prostate Tumor Cells Averts Stemness and Stratifies Drug Sensitivity
To test the hypothesis that the tumor suppressor maspin may reduce microenvironment-dependent prostate tumor cell plasticity and thereby modulate drug sensitivity, scientists established a new schematic combination of 2D, 3D and suspension cultures to enrich prostate cancer cell subpopulations with distinct differentiation potentials. [Cancer Res] Abstract|Full Article
Regulation of Sarcoma Cell Migration, Invasion and Invadopodia Formation by AFAP1L1 through a Phosphotyrosine-Dependent Pathway
The authors identified a novel pathway that directs Lyn/Src family tyrosine kinase signals to the invadopodia to regulate sarcoma cell invasion via the molecule AFAP-1-like-1 (AFAP1L1), a new member of the AFAP (actin filament-associated protein) family. They showed that AFAP1L1 can transform cells, promote migration and co-expression with active Lyn profoundly influences cell morphology and movement. [Oncogene] Abstract
Targeted Type 2 Alveolar Cell Depletion Provides a Dynamic Functional Model for Lung Injury Repair
Researchers demonstrated that specific levels of type 2 alveolar epithelial cell (AEC2) depletion cause altered expression patterns of apoptosis and repair proteins in surviving AEC2 as well as distinct changes in distal lung morphology, pulmonary function, collagen deposition and expression of remodeling proteins in whole lung that persist for up to 60 days. [Am J Respir Cell Mol Biol] Abstract|Press Release
Medtown Ventures, LLC Announces Exclusive License Agreement with Georgia Tech Research Corporation
Medtown Ventures, LLC announced that it has entered into an exclusive license agreement with Georgia Tech Research Corporation for a new adhesive-signature based stem cell selection and isolation technology. To focus on the commercialization of this new cell selection and isolation technology, Medtown has formed a new company, CellectCell™ Inc., with the inventors of the technology. [Medtown Ventures, LLC] Press Release
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