Volume 6.27 | Jul 16

Extracellular Matrix News 6.27 July 16, 2015
Extracellular Matrix News
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Researchers at Penn Develop Scar-Like Culture Systems to Understand and Treat Fibrosis
Researchers developed a ”‘scar in a dish” in order to uncover mechanisms that cells use to sense this fibrous tissue. The system will be helpful for understanding the roots of the scars’ stiffness, and ultimately lead to treatments that would help revert the tissue to its normal consistency. [Press release from University of Pennsylvania discussing online prepublication in Nature Materials] Press Release | Abstract
Weekend-Free Culture hPSCs with mTeSR™1 or TeSR™-E8™
PUBLICATIONS (Ranked by impact factor of the journal)
Matrix Cross-Linking-Mediated Mechanotransduction Promotes Posttraumatic Osteoarthritis
The authors elucidated the mechanistic origin of matrix remodeling and the downstream mechanotransduction pathway and further demonstrated an active role of this mechanism in osteoarthritis pathogenesis. [Proc Natl Acad Sci USA] Abstract

Dynamic Tensile Forces Drive Collective Cell Migration through Three-Dimensional Extracellular Matrices
Researchers showed directly that migration of multicellular cohorts through collagenous matrices occured via a dynamic pulling mechanism, the nature of which had only been inferred previously in three-dimensions. [Sci Rep] Full Article

Extracellular Matrix Properties Regulate the Migratory Response of Glioblastoma Stem Cells in 3D Culture
Scientists developed a composite matrix of hyaluronan structurally supported by a collagen-oligomer fibril network to simulate the brain-tumor extracellular matrix composition. [Tissue Eng Part A] Abstract

Laminin Promotes Metalloproteinase Mediated Dystroglycan Processing to Regulate Oligodendrocyte Progenitor Cell Proliferation
Researchers report that oligodendroglial dystroglycan is cleaved by metalloproteinases, thereby uncoupling oligodendroglia from laminin binding. [J Neurochem] Abstract

The Cytoskeleton Regulates Cell Attachment Strength
Scientists showed that focal adhesion proteins FAK, paxillin, and vinculin but not the cytoskeletal protein actin remained behind after shear-induced detachment of HT1080 fibrosarcoma cells. [Biophys J] Abstract

3D Multi-Layered Fibrous Cellulose Structure Using an Electrohydrodynamic Process for Tissue Engineering
Researchers suggest a new three-dimensional (3D) cellulose scaffold consisting of multi-layered struts made of submicron-sized entangled fibers that were fabricated using an electrohydrodynamic direct jet process that is spin-printing. [J Colloid Interface Sci] Abstract

Corneal Regeneration by Deep Anterior Lamellar Keratoplasty (DALK) Using Decellularized Corneal Matrix
The authors demonstrated the feasibility of DALK using a decellularized corneal matrix obtained by HHP methodology. [PLoS One] Full Article

MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma
Increased miR-375 expression in head and neck squamous cell carcinoma cells suppressed extracellular matrix degradation and reduced the number of mature invadopodia. Higher miR-375 expression did not reduce cellular levels of selected invadopodia-associated proteins, nor was tyrosine phosphorylation of cortactin altered. [Arch Pathol Lab Med] Abstract

Development of Simplified and Defined Cell Culture for hPSCs - Watch Now!
MMPs and ADAMTSs in Intervertebral Disc Degeneration
After a brief description regarding the biology of matrix metalloproteinases (MMPs) and ADAMTSs, the authors mainly focus on their expression profiles, roles and therapeutic potential in intervertebral disc degeneration (IDD). A greater understanding of the catabolic pathways involved in IDD will help to develop potential prophylactic or regenerative biological treatment for degenerative disc disease in the future. [Clin Chim Acta] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Partnership with UCL and Oxford MEStar Ltd in Grant Funded Project
Collagen Solutions plc announced that it is part of a consortium that has been awarded an Arthritis Research UK Point of Care grant to develop novel functionally man-made osteochondral scaffold for large osteochondral defect repairs. Osteochondral injury refers to repetitive trauma within a joint such as the knee or elbow. [Collagen Solutions plc] Press Release

CSU Awarded $1.3 Million NIH Grant for Stem Cell Research
Moo-Yeal Lee, Ph.D., and Chandra Kothapalli, Ph.D., of Cleveland State University (CSU) have been awarded a $1.3 million grant from the National Institutes of Health for innovative stem cell research to improve testing for toxic compounds that could harm the development of the human brain. [Cleveland State University] Press Release

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NEW ICCSCE 2016 : 18th International Conference on Cell and Stem Cell Engineering
September 15-16, 2016
Rome, Italy

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NEW Scientific Writer – Cardiovascular Regeneration (Houston Methodist Research Institute)

NEW Research Fellow – Tissue Engineering & Regenerative Medicine (National Cancer Centre Singapore)

Biomedical Engineer – Cell Therapies & Regenerative Medicine (FDA’s Center for Biologics Evaluation and Research)

PhD Position – Drug Releasing, Nanostructured Biomaterials for Adult Stem Cells (Karlsruhe Institute of Technology)

Associate Scientist – Biomedical Engineering (Shanghai Jiao Tong University)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Postdoctoral Position – Proteoglycan and Dislocations (Inserm)

PhD Position – Tumor Biology (University of Duisburg-Essen)

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