RhoB Loss Induces Rac1-Dependent Mesenchymal Cell Invasion in Lung Cells through PP2A Inhibition
Scientists identified the small GTPase RhoB as a key regulator of bronchial cell morphology in a three-dimensional (3D) matrix. RhoB loss, which is frequently observed during lung cancer progression, induced an epithelial–mesenchymal transition characterized by an increased proportion of invasive elongated cells in 3D. [Oncogene] Abstract
RalB Regulates Contractility-Driven Cancer Dissemination upon TGFβ Stimulation via the RhoGEF GEF-H1
Researchers showed that TGFβ-induced epithelial-mesenchymal transition promotes dissemination of A549 cells in a 2/3D assay, independently of proteolysis, by activating the Rho/ROCK pathway which generates actomyosin-dependent contractility forces that actively remodel the extracellular matrix, as assessed by Traction Force microscopy. [Sci Rep] Full Article
3D-Printed Bioresorbable Scaffold for Periodontal Repair
Investigators provide the first reported human case of treatment of a large periodontal osseous defect with a 3D-printed bioresorbable patient-specific polymer scaffold and signaling growth factor. The treated site remained intact for 12 months following therapy. [J Dent Res] Full Article|Press Release
Proteomic Analysis of Integrin-Associated Complexes from Mesenchymal Stem Cells
To identify regulators of mesenchymal stem cell (MSC) force-sensing, researchers sought to catalog MSC integrin-associated adhesion complex composition. Adhesion complexes formed by MSCs plated on the extracellular matrix ligand fibronectin were isolated and characterized by mass spectrometry. [Proteomics Clin Appl] Abstract
Collagen Based Polyurethanes—A Review of Recent Advances and Perspective
Considering versatile properties of the elongated fibrils and wide industrial and biomedical applications including biocompatibility of polyurethane, this review sheds a light on collagen based polyurethane materials with their potential applications especially focusing the bio-medical field. [Int J Biol Macromol] Abstract
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INDUSTRY NEWS
AMAG Pharmaceuticals to Acquire Cord Blood Registry
AMAG Pharmaceuticals, Inc. announced that it has entered into a definitive agreement to acquire Cord Blood Registry®, the world’s largest stem cell collection and storage company serving pregnant women and their families, for $700 million. [Cord Blood Registry®] Press Release
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