Volume 6.24 | Jun 25

Extracellular Matrix News 6.24 June 25, 2015
Extracellular Matrix News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Researchers Discover Mechanism Leading to BRAF Inhibitor Resistance in Melanoma Patients
Scientists discovered that BRAF inhibitors cause BRAF and PTEN mutant melanoma cells to increase levels of fibronectin. They found that higher levels of fibronectin allow melanoma cells to form their own protective environment that reduces the ability of BRAF inhibitors to kill tumor cells. [Press release from Moffitt Cancer Center discussing online prepublication in Oncogene] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
A Plastic Relationship between Vinculin-Mediated Tension and Adhesion Complex Area Defines Adhesion Size and Lifetime
Researchers used live cell imaging to map time-dependent cross-correlations between vinculin-mediated tension and adhesion complex area, revealing a plastic, context-dependent relationship. [Nat Commun] Full Article

Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology
Investigators elucidated a cross-scale mechanism for tissue assembly and extracellular matrix (ECM) remodeling involving cadherin 2, the ECM protein fibronectin, and its receptor integrin α5. [Dev Cell]
Abstract | Graphical Abstract

Alkaline Phosphatase-Mimicking Peptide Nanofibers for Osteogenic Differentiation
The authors report enhanced bone regeneration efficiency through peptide nanofibers carrying both catalytic and matrix-regulatory functions of alkaline phosphatase, a versatile enzyme that plays a critical role in bone formation by regulating phosphate homeostasis and calcifiable bone matrix formation. [Biomacromolecules] Abstract | Graphical Abstract

Immunomodulatory Polymeric Scaffold Enhances Extracellular Matrix Production in Cell Co-Cultures under Dynamic Mechanical Stimulation
Researchers determined if a tubular degradable polyurethane scaffold could be used in a co-culture system along with dynamic biomechanical stimulus conditions in order to direct monocytes to enhance tissue generation, and to better comprehend the different ways in which monocytes/macrophages may contribute to new tissue production. [Acta Biomater] Abstract

Mechanical Overloading Causes Mitochondrial Superoxide and SOD2 Imbalance in Chondrocytes Resulting in Cartilage Degeneration
A genetically manipulated model revealed that Sod2 deficiency in chondrocytes resulted in mitochondrial superoxide overproduction and dysfunction, thus leading to cartilage degeneration. [Sci Rep] Full Article

Amniotic Fluid Stem Cells Provide Considerable Advantages in Epidermal Regeneration: B7H4 Creates a Moderate Inflammation Microenvironment to Promote Wound Repair
Researchers examined the advantages of using human amniotic fluid stem (hAFS) cells in skin wound healing. During wound repair, hAFS cells did not directly secrete repair-related factors, such as bFGF, VEGF, CXCL12, TGF-β1 and KGF, and provided a moderate inflammation reaction with lower expression of IL-1β, IL-6, TNF-α, Cox2 and Mac3. [Sci Rep] Full Article

The Role of iNOS in Cholesterol-Induced Liver Fibrosis
The authors investigated the role of inducible nitric oxide synthase (iNOS) in cholesterol-induced liver fibrosis by feeding wild-type and iNOS-deficient mice with control or high-cholesterol diet for six weeks. Enhanced liver fibrosis in the presence of iNOS was associated with hypoxia-inducible factor-1α stabilization, matrix metalloproteinase-9 expression, and enhanced hepatic DNA damage. [Lab Invest] Abstract

Postinfarction Functional Recovery Driven by a Three-Dimensional Engineered Fibrin Patch Composed of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells
Researchers examined the ability of a three-dimensional engineered fibrin patch filled with human umbilical cord blood-derived mesenchymal stem cells to induce recovery of cardiac function after myocardial infarction. [Stem Cells Transl Med] Abstract | Press Release

Laminin Peptide-Immobilized Hydrogels Modulate Valve Endothelial Cell Hemostatic Regulation
Investigators used a poly(ethylene glycol) diacrylate hydrogel platform to evaluate the effects of substrate stiffness and cell adhesive ligands on valve endothelial cells phenotype and expression of hemostatic genes. [PLoS One] Full Article

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REVIEWS
Forging a Signature of In Vivo Senescence
The authors highlight caveats in interpreting the importance of suboptimal senescence-associated biomarkers, expressed either alone or in combination. They advocate that more-specific descriptors be substituted for the now broadly applied umbrella term ‘senescence’ in defining the suite of diverse physiological responses to cellular stress. [Nat Rev Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
 
INDUSTRY NEWS
$50 Million Gift Creates Meinig School of Biomedical Engineering
A decade after its creation, Cornell’s Department of Biomedical Engineering has received a $50 million endowment gift that will expand and elevate it as the Nancy E. and Peter C. Meinig School of Biomedical Engineering. [Cornell University] Press Release

Ontario Invests in Better Health and Economic Opportunity through Support for Ontario Institute for Regenerative Medicine
A new $25 million commitment positions Ontario to be an early adopter of new treatments and technologies emerging from research and commercial developments in regenerative medicine. [Ontario Institute for Regenerative Medicine] Press Release

A Better Way to Build Bones
A team of researchers at the New York University Polytechnic School of Engineering, NYU School of Medicine, and Stanford University School of Medicine have received a $1.1 million grant from the U.S. Veterans Health Administration’s Office of Rehabilitation Research and Development to pioneer a novel approach to harnessing the body’s own chemical signals to speed bone regeneration and improve repair. [New York University Polytechnic School of Engineering] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 3rd International Annual Conference of the German Stem Cell Network (GSCN)
September 9-11, 2015
Frankfurt, Germany

Visit our events page to see a complete list of events in the extracellular matrix community.
 
JOB OPPORTUNITIES
NEW Group Leader – Biomedical Engineering (Helmholtz-Zentrum Geesthacht)

NEW PhD Position – Drug Releasing, Nanostructured Biomaterials for Adult Stem Cells (Karlsruhe Institute of Technology)

Research Associate – Novel Therapeutics and Biomarkers in Peripheral Ischemia (University of Bristol)

Associate Scientist – Biomedical Engineering (Shanghai Jiao Tong University)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Postdoctoral Fellow – Neural Tissue Engineering (Nanyang Technological University)

Postdoctoral Position – Proteoglycan and Dislocations (Inserm)

PhD Position – Tumor Biology (University of Duisburg-Essen)


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