| | | PUBLICATIONS (Ranked by impact factor of the journal) |
Aligned-Braided Nanofibrillar Scaffold with Endothelial Cells Enhances Arteriogenesis
Investigators sought to enhance the angiogenic capacity of endothelial cells (ECs) using nanoscale signaling cues from aligned nanofibrillar scaffolds in the setting of tissue ischemia. Human ECs showed greater outgrowth from aligned scaffolds than from nonpatterned scaffolds. [ACS Nano] Abstract
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Graphical Abstract
Artificial Membrane-Binding Proteins Stimulate Oxygenation of Stem Cells during Engineering of Large Cartilage Tissue
Scientists showed that pre-treating human mesenchymal stem cells with synthetic membrane-active myoglobin-polymer–surfactant complexes can provide a reservoir of oxygen capable of alleviating necrosis at the center of hyaline cartilage. [Nat Commun] Full Article
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Press Release
Targeting of β1 Integrins Impairs DNA Repair for Radiosensitization of Head and Neck Cancer Cells
Researchers examined the impact of β1 integrin targeting on the repair of radiation-induced DNA double-strand breaks (DSBs). β1 integrin targeting impaired repair of radiogenic DSB in vitro and in vivo and reduced the protein expression of Ku70, Rad50 and Nbs1. [Oncogene] Abstract
Stromal miR-200s Contribute to Breast Cancer Cell Invasion through CAF Activation and ECM Remodeling
Investigators found that miR-200s, which are generally downregulated in activated cancer-associated fibroblasts (CAFs) in breast cancer tissues and in normal fibroblasts (NFs) activated by breast cancer cells, are direct mediators of NF reprogramming into CAFs and of extracellular matrix (ECM) remodeling. [Cell Death Differ] Full Article
Simple Coating with Fibronectin Fragment Enhances Stainless Steel Screw Osseointegration in Healthy and Osteoporotic Rats
The authors present a simple coating strategy based on passive adsorption of FN7-10, a recombinant fragment of human fibronectin encompassing the major cell adhesive, integrin-binding site, onto 316-grade stainless steel (SS). FN7-10 coating on SS surfaces promoted α5β1 integrin-dependent adhesion and osteogenic differentiation of human mesenchymal stem cells. [Biomaterials] Abstract
A 3D Human Neural Cell Culture System for Modeling Alzheimer’s Disease
Scientists provide instructions for the generation and analysis of 3D human neural cell cultures, including the production of genetically modified human neural progenitor cells (hNPCs) with familial Alzheimer’s disease (AD) mutations, the differentiation of the hNPCs in a 3D matrix and the analysis of AD pathogenesis. [Nat Protoc] Abstract
Quantification of Regenerative Potential in Primary Human Mammary Epithelial Cells
Researchers present an organoid regeneration assay in which freshly isolated human mammary epithelial cells are cultured in adherent or floating collagen gels, corresponding to a rigid or compliant matrix environment. In both conditions, luminal progenitors form spheres, whereas basal cells generate branched ductal structures. [Development] Abstract
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Full Article
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Press Release
Skin Rejuvenation with Non-Invasive Pulsed Electric Fields
The authors report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. [Sci Rep]
Full Article
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Press Release
Synoviocyte Derived-Extracellular Matrix Enhances Human Articular Chondrocyte Proliferation and Maintains Re-Differentiation Capacity at Both Low and Atmospheric Oxygen Tensions
Porcine synoviocyte-derived extracellular matrix and low oxygen tension were assessed for their ability to enhance human articular chondrocyte expansion and maintain re-differentiation potential. Human chondrocytes expanded twice as fast on devitalized synoviocyte matrix vs. tissue culture plastic, and cells retained their re-differentiation capacity for twice the number of population doublings. [PLoS One] Full Article
Nitric Oxide Regulates Cell Behavior on an Interactive Cell-Derived Extracellular Matrix Scaffold
Researchers investigated the regulatory effect of nitric oxide (NO) on human mesenchymal stem cells in an interactive extracellular matrix (ECM)-rich microenvironment. In order to mimic the in vivo stromal environment in wound site, a cell-derived ECM scaffold that was able to release NO within the range of in vivo wound fluid NO level was fabricated. [J Biomed Mater Res A] Abstract
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| | | INDUSTRY NEWS |
CorMatrix® Cardiovascular, Inc. Receives Two Additional U.S. Patents for ECM® Biomaterial Compositions
CorMatrix® Cardiovascular, Inc. announced the issuance of U.S. Patent No. 9,034,367 entitled Articles for Tissue Regeneration with Biodegradable Polymers. The patent covers grafts and compositions comprising a variety of extracellular matrix (ECM®) materials, including small intestine submucosa, stomach submucosa, liver basement membrane and urinary bladder submucosa. [CorMatrix® Cardiovascular, Inc.] Press Release
AxoGen, Inc. Announces Completion of a Pilot Clinical Study Assessing Cavernous Nerve Reconstruction with Avance® Nerve Graft following Radical Prostatectomy
AxoGen, Inc. announced results from a pilot clinical study of cavernous nerve reconstruction during radical prostatectomy procedures using its Avance® Nerve Graft. [AxoGen, Inc.] Press Release
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| | | EVENTS |
NEW Cell Culture 2016
February 2-4, 2016
London, United Kingdom
Visit our events page to see a complete list of events in the extracellular matrix community.
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