Volume 6.19 | May 21

Extracellular Matrix News 6.19 May 21, 2015
Extracellular Matrix News
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Designing Better Medical Implants
Researchers have come up with a way to reduce immune-system rejection. They found that the geometry of implantable devices has a significant impact on how well the body will tolerate them. [Press release from Massachusetts Institute of Technology discussing online prepublication in Nature Materials]
Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Directional Cell Movement through Tissues Is Controlled by Exosome Secretion
Researchers used intravital imaging to demonstrate that secretion of exosomes from late endosomes is required for directionally persistent and efficient in vivo movement of cancer cells. Inhibiting exosome secretion or biogenesis leads to defective tumor cell migration associated with increased formation of unstable protrusions and excessive directional switching. [Nat Commun] Full Article

Stromal Fibroblasts Facilitate Cancer Cell Invasion by a Novel Invadopodia-Independent Matrix Degradation Process
The authors report that cells of mesenchymal origin, including tumor-associated fibroblasts, degrade substantial amounts of surrounding matrix by a mechanism independent of conventional invadopodia. [Oncogene] Abstract

A Ring Barrier–Based Migration Assay to Assess Cell Migration In Vitro
Scientists outline a protocol for the in vitro study of cell migration using a ring barrier–based assay. An advantage of this assay over the conventional scratch assay is that the cells move over an unaltered and virgin surface, and thus the effect of matrix components on cell migration can be studied. [Nat Protoc] Abstract

Development of a Gene-Activated Scaffold Platform for Tissue Engineering Applications Using Chitosan-pDNA Nanoparticles on Collagen-Based Scaffolds
Researchers explored the potential of a series of collagen-based scaffolds as gene-activated scaffold platforms with potential in a range of tissue engineering applications. The potential of chitosan, a biocompatible material derived from the shells of crustaceans, as a gene delivery vector was assessed using mesenchymal stem cells. [J Control Release] Abstract

Arachidonic Acid Promotes Skin Wound Healing through Induction of Human MSC Migration by MT3-MMP-Mediated Fibronectin Degradation
Scientists investigated skin wound-healing effect of arachidonic acid-stimulated human umbilical cord blood-derived mesenchymal stem cells (MSCs) in vivo and its molecular mechanism in vitro. [Cell Death Dis] Full Article

Biodegradable CSMA/PECA/Graphene Porous Hybrid Scaffold for Cartilage Tissue Engineering
Investigators prepared a novel hybrid scaffold composed of methacrylated chondroitin sulfate (CSMA), poly(ethylene glycol) methyl ether-ε-caprolactone-acryloyl chloride (PECA) and graphene oxide and evaluated its potential application in cartilage tissue engineering. [Sci Rep] Full Article

The Role of Cyclooxygenase-2, Interleukin-1β and Fibroblast Growth Factor-2 in the Activation of Matrix Metalloproteinase-1 in Sheared-Chondrocytes and Articular Cartilage
Using primary chondrocytes and T/C-28a2 chondrocytic cells as model systems, researchers report that prolonged application of high fluid shear to human chondrocytes induced the synthesis of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2, which led to a marked increase in MMP-1 expression. [Sci Rep] Full Article

A Hyaluronan-Based Injectable Hydrogel Improves the Survival and Integration of Stem Cell Progeny following Transplantation
Investigators designed an injectable and bioresorbable hydrogel blend of hyaluronan and methylcellulose and tested it with two cell types in two animal models, gaining an understanding of its general applicability for enhanced cell distribution, survival, integration, and functional repair relative to conventional cell delivery in saline. [Stem Cell Rep] Full Article | Press Release

Learn more about our cell attachment substrates and matrices for stem cell research.
Recent Advances in Re-Engineered Liver: De-Cellularization and Re-Cellularization Techniques
Through de-cellularization and re-cellularization methods, re-engineered liver may provide a promising alternative for treating patients with end-stage liver disease. The authors highlight the challenges still to be overcome and present an overview and summary of methods of de-cellularization and re-cellularization strategies, together with a view on future directions that may lead to the regeneration of a functional liver. [Cytotherapy] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Cancer Prevention and Research Institute of Texas Awards 41 New Grants
The Cancer Prevention and Research Institute of Texas awarded 28 grants through its academic research program, 11 grants through its prevention program and two grants through its product development research program. [Cancer Prevention and Research Institute of Texas] Press Release

NIH Awards $2.2 Million Grant to William J. Brunken, PhD, for Vision Research
William J. Brunken, Ph.D., of Upstate Medical University, has been awarded a $2.2 million grant from the National Institutes of Health (NIH) for a five-year study investigating the role of extracellular matrix in retinal development and disease. [Upstate Medical University] Press Release

UB and Roswell Park Receive $1.85 Million Grant to Launch Stem Cell Research Program
University at Buffalo (UB) and Roswell Park Cancer Institute researchers have been awarded a $1.85 million grant to create an interdisciplinary stem cell research training program. The program, called Stem Cells in Regenerative Medicine, will bring together 18 faculty members in UB’s School of Engineering and Applied Sciences and the School of Medicine and Biomedical Sciences, and Roswell Park’s Graduate Division. [University of Buffalo] Press Release

From our sponsor: Learn about air-liquid interface culture for respiratory research. Watch the video.
FTC, All 50 States and D.C. Charge Four Cancer Charities with Bilking Over $187 Million from Consumers
The Federal Trade Commission and 58 law enforcement partners from every state and the District of Columbia have charged four sham cancer charities and their operators with bilking more than $187 million from consumers. [Federal Trade Commission] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW International Bioprinting Congress
July 9-10, 2015
Singapore, Singapore

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW PhD Positions – Cartilage Regeneration in Joints and Intervertebral Disc Diseases (Percuros B.V.)

NEW Assistant Professor – Instructive Biomaterials Engineering (Maastricht University)

NEW Faculty Positions – Regenerative Medicine for Kidney or Liver Regeneration or Transplantation (University of Texas Health Science Center at Houston)

PhD Position – Tumor Biology (University of Duisburg-Essen)

Postdoctoral Fellow – Disseminated Tumor Cell Biology (Fred Hutchinson Cancer Research Center)

PhD Position – Cartilage Regeneration in Joints (ProCore Bio Med Ltd.)

Postdoctoral Fellow – Neural Tissue Engineering (Nanyang Technological University)

Postdoctoral Position – Cell Signaling (Columbia University Medical Center)

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