Scientists Regenerate Bone Tissue Using Only Proteins Secreted by Stem Cells
Scientists have discovered a way to regrow bone tissue using the protein signals produced by stem cells. The study is the first to extract the necessary bone-producing growth factors from stem cells and show that these proteins are sufficient to create new bone. [Press release from Gladstone Institutes discussing online prepublication in Scientific Reports] Press Release|Full Article
Dysregulation of Astrocyte Extracellular Signaling in Costello Syndrome
Human induced pluripotent stem cells derived from patients with Costello syndrome differentiated to astroglia more rapidly in vitro than those derived from wild-type cell lines with normal Harvey rat sarcoma viral oncogene homolog, exhibited hyperplasia, and also generated an abundance of extracellular matrix remodeling factors and proteoglycans. [Sci Transl Med] Abstract
Finding and Tracing Human MSC in 3D Microenvironments with the Photoconvertible Protein Dendra2
A simple and reliable imaging technique was developed to study mesenchymal stem/stromal cell (MSC) dynamical behavior in natural and bioengineered 3D matrices. Human MSC were transfected to express a fluorescent photoswitchable protein, Dendra2, which was used to highlight and follow the same group of cells for more than seven days, even if removed from the microscope to the incubator. [Sci Rep]
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