Volume 6.17 | May 7

Extracellular Matrix News 6.17 May 7, 2015
Extracellular Matrix News
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Study Uncovers Foundations of Heart Regeneration
While the human heart can’t heal itself, the zebrafish heart can easily replace cells lost by damage or disease. Researchers have discovered properties of a mysterious outer layer of the heart known as the epicardium that could help explain the fish’s remarkable ability to regrow cardiac tissue. [Press release from Duke University discussing online prepublication in Nature] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Metabolism Links Bacterial Biofilms and Colon Carcinogenesis
Using metabolomics, researchers investigated the metabolic influence that microbial biofilms have on colon tissues and the related occurrence of cancer. Patient-matched colon cancers and histologically normal tissues, with or without biofilms, were examined. [Cell Metab] Abstract | Graphical Abstract | Press Release

Collagen Degradation and MMP9 Activation by Enterococcus faecalis Contribute to Intestinal Anastomotic Leak
Researchers demonstrated that the commensal bacterium E. faecalis contributes to the pathogenesis of anastomotic leak through its capacity to degrade collagen and to activate tissue matrix metalloproteinase 9 (MMP9) in host intestinal tissues. [Sci Transl Med] Abstract | Press Release

Reinforcement of Hydrogels Using Three-Dimensionally Printed Microfibers
Investigators reinforced soft hydrogels with highly organized, high-porosity microfiber networks that are 3D-printed with a technique termed as melt electrospinning writing. Human chondrocytes embedded in the composites were viable, retained their round morphology and were responsive to an in vitro physiological loading regime in terms of gene expression and matrix production. [Nat Commun] Abstract

FOXO1 Differentially Regulates Both Normal and Diabetic Wound Healing
Scientists previously demonstrated that lineage-specific Foxo1 deletion in keratinocytes interfered with normal wound healing and keratinocyte migration. Surprisingly, the same deletion of Foxo1 in diabetic wounds had the opposite effect, significantly improving the healing response. [J Cell Biol] Abstract | Press Release

Systematic Optimization of Human Pluripotent Stem Cells Media Using Design of Experiments
Using pluripotency and cell growth as read-outs, investigators determined the optimal concentration of both basic fibroblast growth factor and neuregulin-1 beta 1. The resulting formulation improved the maintenance and passage of human pluripotent stem cells in both normal and stressful conditions, and affected trimethylated histone 3 lysine 27 epigenetic status after genetic reprogramming. [Sci Rep] Full Article | Press Release

Islet Endothelial Cells Induce Glycosylation and Increase Cell-Surface Expression of Integrin β1 in

Islet-derived endothelial cell-induced pseudoislets were used to study the expression and posttranslational modification of the extracellular matrix receptor integrin β1. A wide array of integrin β subunits were detected in βTC3 and NIT-1 insulinomas, as well as in primary islets, with integrin β1 mRNA and protein detected in all three cell types. [J Biol Chem] Abstract | Full Article

Multiscale Fabrication of Biomimetic Scaffolds for Tympanic Membrane Tissue Engineering
A multiscale approach based on electrospinning and additive manufacturing was investigated to fabricate scaffolds, based on FDA approved copolymers, resembling the anatomic features and collagen fiber arrangement of the human tympanic membrane (TM). TM scaffolds were cultured in vitro with human mesenchymal stromal cells, which were viable, metabolically active and organized following the anisotropic character of the scaffolds. [Biofabrication] Abstract | Press Release

Differential β3 Integrin Expression Regulates the Response of Human Lung and Cardiac Fibroblasts to Extracellular Matrix and Its Components
Researchers hypothesized that extracellular matrix (ECM) structure and composition, fibroblast source, and integrin expression would influence fibroblast phenotype. Human cardiac fibroblasts and normal human lung fibroblasts were cultured on intact cardiac ECM, collagen gels and coatings composed of cardiac ECM, lung ECM, and individual ECM components for 48 hours. [Tissue Eng Part A] Abstract

Autologous Adipose Stromal Cells Seeded on a Human Collagen Matrix for Dermal Regeneration in Chronic Wounds: Clinical Proof of Concept
Researchers developed a biological dressing made of adipose-derived stromal cells (ASC) on a human acellular collagen matrix (HACM). In vitro, the genetic stability during early and late passages and vascular endothelial growth factor secretion were assessed. ASC adhesion and spreading on HACM were preliminarily studied. [Plast Reconstr Surg] Abstract

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Strategies for Improving the Physiological Relevance of Human Engineered Tissues
The authors examine important robust methods for sustained, steady-state, in vitro culture. To achieve ‘physiologically relevant’ tissues in vitro additional complexity must be introduced to provide suitable transport, cell signaling, and matrix support for cells in 3D environments to achieve stable readouts of tissue function. [Trends Biotechnol] Abstract

The (Dys)functional Extracellular Matrix
The authors provide an overview of the structural, compositional, and mechanical properties of the extracellular matrix that instruct cell behaviors. Case studies are reviewed that highlight mechanotransduction in the context of two distinct tissues: tendons and the heart. [Biochim Biophys Acta] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
3-D Printed Trachea among Key Mount Sinai Research Presented
A team of researchers from Icahn School of Medicine have combined 3D printing technology with human stem cells to create the first successful 3D-printed biologic tracheal graft in an animal model. [Press release from Icahn School of Medicine at Mount Sinai discussing research presented at the 2015 American Association for Thoracic Surgery (AATS) Meeting, Seattle] Press Release

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UI Team Developing Bioactive Gel to Treat Knee Injuries
A University of Iowa (UI) orthopedics research team is working on a hydrogel solution with hopes it will result in a minimally invasive, practical, and inexpensive approach for repairing cartilage and preventing osteoarthritis. [University of Iowa] Press Release

Bone Biologics Corp Completes Financing with Hankey Capital, LLC
Bone Biologics, Corp. announced the completion of a $2M funding round with Hankey Capital, LLC. The company is developing a proprietary protein for use in bone regenerative medicine using the patented recombinant human protein known as UCB-1 for use with patients undergoing spinal fusion. [Bone Biologics, Corp. (PR Newswire Association LLC)] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Biofabrication 2015
November 7-9, 2015
Utrecht, Netherlands

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Commercial Marketing Manager – Cell Culture (Thermo Fisher Scientific)

NEW Postdoctoral Position – Cardiovascular Research (University of Oslo)

NEW PhD Position – Cartilage Regeneration in Joints (Cardiff University)

NEW PhD Position – Cartilage Regeneration in Joints (ProCore Bio Med Ltd.)

Postdoctoral Fellow – Neural Tissue Engineering (Nanyang Technological University)

Cell Biologist – Neurodegeneration (MedImmune LLC)

Postdoctoral Position – Cell Signaling (Columbia University Medical Center)

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