Cell Type Responsible for Scarring, Skin-Cancer Growth Identified
A single cell type in the skin of mice is a major contributor to scarring after wound healing or radiation damage, and facilitates the growth of melanoma. Blocking the cell’s activity in humans may be possible with currently approved drugs. [Press release from Stanford University discussing online prepublication in Science] Press Release|Abstract
Regulated Delivery of Molecular Cargo to Invasive Tumor-Derived Microvesicles
Researchers demonstrated that in amoeboid-like invasive tumor cell lines, the v-SNARE, VAMP3, regulates delivery of microvesicle cargo such as the membrane-type 1 matrix metalloprotease (MT1-MMP) to shedding microvesicles. MT1-MMP delivery to nascent microvesicles depends on the association of VAMP3 with the tetraspanin CD9 and facilitates the maintenance of amoeboid cell invasion. [Nat Commun] Abstract|Press Release
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INDUSTRY NEWS
NIH Funds WPI Study Aimed at Engineering More Natural and Durable Replacement Heart Valves
With a $450,000 grant from the National Institutes of Health (NIH), researchers at Worcester Polytechnic Institute (WPI) will analyze how mechanical forces and cellular growth factors affect the growth and development of human heart valves to advance the long-term goal of using tissue engineering to develop replacement valves that are more natural and longer-lasting than current replacement valves. [Worcester Polytechnic Institute] Press Release
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