Volume 6.14 | Apr 16

Extracellular Matrix News 6.14 April 16, 2015
Extracellular Matrix News
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Long-Term Controlled Delivery of rhBMP-2 from Collagen-Hydroxyapatite Scaffolds for Superior Bone Tissue Regeneration
Recombinant human bone morphogenetic protein 2 (rhBMP-2) was combined with a collagen-hydroxyapatite (CHA) scaffold to produce a highly porous CHA scaffold supporting the controlled release of the protein over the course of 21 days whilst maintaining in vitro bioactivity as demonstrated by enhanced alkaline phosphatase activity and calcium production by preosteoblasts cultured on the scaffold. [J Control Release] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Delineation of In Vitro Chondrogenesis of Human Synovial Stem Cells following Preconditioning Using Decellularized Matrix
Investigators found that expansion on decellularized extracellular matrix full of three-dimensional nanostructured fibers provided synovium-derived stem cells with unique surface profiles, low elasticity but large volume as well as a fibroblast-like shape. [Acta Biomater] Abstract

Loss of CD147 Results in Impaired Epithelial Cell Differentiation and Malformation of the Meibomian Gland
Scientists identified a novel function for CD147, a transmembrane protein that promotes tissue remodeling through induction of matrix metalloproteinases, in regulating meibocyte differentiation and activity. [Cell Death Dis] Full Article

Influence of Vascular Endothelial Growth Factor Stimulation and Serum Deprivation on Gene Activation Patterns of Human Adipose Tissue-Derived Stromal Cells
Researchers investigated the effect of in vitro serum deprivation and vascular endothelial growth factor stimulation on gene expression patterns of adipose tissue-derived stromal cells. [Stem Cell Res Ther]
Abstract | Full Article

Collagen and Elastin Cross-Linking Is Altered during Aberrant Late Lung Development Associated with Hyperoxia
Scientists demonstrated that collagen and elastin cross-linking are perturbed during the arrested alveolarization of developing mouse lungs exposed to hyperoxia. [Am J Physiol Lung Cell Mol Physiol] Abstract

High-Mobility Group Box 1 Accelerates Lipopolysaccharide-Induced Lung Fibroblast Proliferation In Vitro: Involvement of the NF-κB Signaling Pathway
Researchers investigated the effects of lipopolysaccharide (LPS)- and/or high-mobility group box 1 (HMGB1)-stimulating murine lung fibroblasts on gene expression using various assays in vitro. Secretion of matrix metalloproteinase (MMP)-2 and MMP-9, and tissue inhibitor of metalloproteinase 2 was significantly upregulated after treatment with LPS, HMGB1, or their combination. [Lab Invest] Abstract

Periodontal Regeneration Employing Gingival Margin-Derived Stem/Progenitor Cells in Conjunction with IL-1ra-Hydrogel Synthetic Extracellular Matrix
Scientists investigated the periodontal regenerative potential of gingival margin-derived stem/progenitor cells in conjunction with IL-1ra releasing hyaluronic acid synthetic extracellular matrix [J Clin Periodontol] Abstract

Colorectal Cancer Metastases Settle in the Hepatic Microenvironment Through α5β1 Integrin
Researchers investigated the role of α5β1 integrin and how the microenvironment influences this adhesion molecule, in a model of colon cancer progression to the liver. [J Cell Biochem] Abstract

No Effects of Hyperosmolar Culture Medium on Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells despite Upregulation Extracellular Matrix Genes
Investigators determined the effect of osmolality and different osmolytes on the regeneration by human nucleus pulposus cells through gene expression and extracellular matrix production. [Spine] Abstract

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What Understanding Tendon Cell Differentiation Can Teach Us about Pathological Tendon Ossification
The authors present chronic tendon pathologies associated with abnormal ossification. They moreover present the factors known to influence tendon cell differentiation and trans-differentiation, with a particular emphasis on extracellular environment, mechanical stimulation and several soluble factors that can tip the balance toward one or another lineage. [Histol Histopathol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Synthetic Muscle Developed with PPPL Scientists’ Help Ready for Launch
Lenore Rasmussen developed synthetic muscle material at RAS Labs and has worked closely with researchers and engineers at the U.S. Department of Energy’s Princeton Plasma Physics Laboratory (PPPL) to develop the material’s ability to adhere to metal. The Synthetic Muscle™ could be used in robotics in deep space travel such as travel to Mars because of its radiation resistance. [Princeton Plasma Physics Laboratory] Press Release

RepliCel Life Sciences Receives Approval to Conduct Clinical Trial for Patients with Chronic Achilles Tendinosis
RepliCel Life Sciences Inc. announced that it has received approval from the University of British Columbia (UBC) Clinical Research Ethics Board to conduct a Phase I/II clinical trial at the UBC Hospital. The trial will investigate the potential of RepliCel’s tendon repair product, RCT-01, to treat chronic tendon injury. [RepliCel Life Sciences Inc.] Press Release

Bone Therapeutics Establishes US Subsidiary
Bone Therapeutics announced that it has established its US based subsidiary, Bone Therapeutics USA Inc. in Boston, Massachusetts. The establishment of the US headquarters is the first step for the company to move forward its US clinical trials program. [Bone Therapeutics S.A.] Press Release

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NEW Cell Therapy Bioprocessing & Commercialization
September 30-October 1, 2015
Alexandria, United States

NEW Targeting Cell Death Mechanisms for the Treatment of Human Diseases
November 9-13, 2015
Suzhou, China

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW PhD Positions – Cartilage Regeneration in Joints and Intervertebral Disc Diseases (AO Research Institute)

Postdoctoral Position – Cancer Imaging (King’s College London)

Cell Biologist – Neurodegeneration (MedImmune LLC)

Postdoctoral Position – ECM Integrin Signaling (Massachusetts General Hospital and Harvard Medical School)

Research Associate – Triple Negative Breast Cancer (King’s College London)

Postdoctoral Position – Cell Signaling (Columbia University Medical Center)

PhD Position – Early Human Brain Development Modeling with hiPSCs (University of Bonn)

Postdoctoral Fellow – Role of ECM Proteolysis in Normal and Pathological Corneal Repair (UCSF)

Associate Director – Cell Therapy (Stelfox)

PhD Studentship – Cell Migration (MOCA Institute of Molecular and Cellular Anatomy)

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