Volume 6.12 | Apr 2

Extracellular Matrix News 6.12 April 2, 2015
Extracellular Matrix News
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Control of Cell-Cell Forces and Collective Cell Dynamics by the Intercellular Adhesome
Researchers studied the interplay between cell-cell adhesion proteins, intercellular forces and epithelial tissue dynamics. They showed that collective cellular responses to selective perturbations of the intercellular adhesome conform to three mechanical phenotypes. [Nat Cell Biol] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
On the Tear Resistance of Skin
Scientists quantified the extreme tear resistance of skin and identified the underlying structural features, which lead to its sophisticated failure mechanisms. They expressed the deformation in terms of four mechanisms of collagen fibril activity in skin under tensile loading that virtually eliminate the possibility of tearing in pre-notched samples. [Nat Commun] Full Article

Interactions of DPP-4 and Integrin β1 Influences Endothelial-to-Mesenchymal Transition
Scientists tested whether dipeptidyl peptidase (DPP)-4-integrin β1 interactions have a role in endothelial-to-mesenchymal transition in the renal fibrosis of diabetic nephropathy. [Kidney Int] Abstract

Extracellular Matrix Remodeling and Its Contribution to Protective Adaptation following Lengthening Contractions in Human Muscle
Researchers determined the contribution of extracellular matrix remodeling to the protective adaptation of human skeletal muscle known as the repeated-bout effect. [FASEB J] Abstract

Mechanical Interplay between Invadopodia and the Nucleus in Cultured Cancer Cells
Investigators showed that the core actin bundle of most invadopodia interacts with integrin-containing matrix adhesions at its basal end, extends through a microtubule-rich cytoplasm, and at its apical end, interacts with the nuclear envelope and indents it. [Sci Rep] Full Article

Fibulin1C Peptide Induces Cell Attachment and Extracellular Matrix Deposition in Lung Fibroblasts
Researchers identified the bioactive region/s of fibulin-1C which promotes fibrosis. Peptide effects on in vitro measures of fibrosis: cell attachment, proliferation and viability, and extracellular matrix deposition, were examined. [Sci Rep] Full Article

Integrin α3β1 Regulates Kidney Collecting Duct Development via TRAF6-Dependent K63-Linked Polyubiquitination of Akt
Investigators showed that α3 chain containing laminins promote normal ureteric bud branching morphogenesis and that laminin 332 is a better substrate than laminin 511 for stimulating integrin α3β1-dependent collecting duct cell functions. [Mol Biol Cell] Abstract | Full Article

Matrix Metalloproteinase-9 Mediates Post-Hypoxic Vascular Pruning of Cerebral Blood Vessels by Degrading Laminin and Claudin-5
In light of the important role of matrix metalloproteinases (MMPs) in tissue remodeling, scientists examined the role of MMP-9 in remodeling of cerebral blood vessels, both in hypoxia-induced angiogenesis and in the vascular pruning that accompanies the switch from hypoxia back to normoxia. [Angiogenesis] Full Article

EMMPRIN Regulates β1 Integrin-Mediated Adhesion through Kindlin-3 in Human Melanoma Cells
The authors report that EMMPRIN can regulate melanoma cell adhesion to the extracellular matrix through an interaction with β1 integrin involving Kindlin-3. EMMPRIN knockdown in the human melanoma cell line M10 using siRNA decreased cell invasion and significantly increased cell adhesion and spreading. [Exp Dermatol] Abstract

Transglutaminase 2 Interactions with Extracellular Matrix Proteins as Probed with Celiac Disease Autoantibodies
Researchers characterized the microenvironment of transglutaminase 2 (TG2) in the extracellular matrix (ECM) in order to gain insight into the antigenic structures that are recognized by autoantibodies in celiac disease. A panel of TG2-specific monoclonal antibodies established from gut plasma cells of celiac disease patients was employed as probes to characterize the interactions between TG2 and ECM constituents. [FEBS J] Abstract

αII-Spectrin Regulates Invadosome Stability and Extracellular Matrix Degradation
FRAP and live-imaging analysis revealed that αII-spectrin is a highly dynamic component of invadosomes as actin present in the structures core. Knockdown of αII-spectrin expression destabilized invadosomes and reduced the ability of the remaining invadosomes to digest the extracellular matrix and to promote invasion. [PLoS One] Full Article

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Emerging Properties of Adhesion Complexes: What Are They and What Do They Do?
The regulation of cell adhesion machinery is central to a wide variety of developmental and pathological processes and occurs primarily within integrin-associated adhesion complexes. The authors review recent advances that have furthered our understanding of the composition, organization, and dynamics of these complexes, and provide an updated view on their emerging functions. [Trends Cell Biol] Abstract

Mechanical Interactions and Crosstalk between Corneal Keratocytes and the Extracellular Matrix
The authors provide an overview of the biochemical and biophysical factors regulating the mechanical interactions between corneal keratocytes and the stromal ECM at the cellular level. [Exp Eye Res] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Stem Cells May Significantly Improve Tendon Healing, Reduce Retear Risk in Rotator Cuff Surgery
An injection of a patient’s bone marrow stem cells during rotator cuff surgery significantly improved healing and tendon durability. Each year in the U.S., more than 2 million people have rotator cuff surgery to re-attach their shoulder tendon to the head of the humerus. [Press release from American Academy of Orthopaedic Surgeons (AAOS) discussing research presented at the 2015 Annual Meeting of the AAOS, Las Vegas] Press Release

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UC Researchers Awarded Stem Cell Grants
University of California (UC) researchers from two campuses received three grants totaling more than $12 million in funding from the state’s stem cell agency to develop stem cell treatments for Huntington’s disease, spina bifida and chronic diabetic wounds. [UC Health] Press Release

Bone Therapeutics Treats First Patients in ALLOB® Phase IIa Spinal Fusion Trial
Bone Therapeutics announced that the first four patients in the Phase IIa proof-of-concept study for spinal fusion procedures have been treated with Bone Therapeutics’ allogeneic osteoblastic (bone-forming) cell therapy product, ALLOB®. [Bone Therapeutics S.A.] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Regenerative Medicine Workshop at Hilton Head
May 13-16, 2015
Hilton Head Island, United States

NEW Cold Spring Harbor Stem Cell Biology Meeting
October 7-11, 2015
Cold Spring Harbor, United States

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Postdoctoral Position – Cancer Imaging (King’s College London)

NEW Cell Biologist – Neurodegeneration (MedImmune LLC)

NEW Postdoctoral Position – ECM Integrin Signaling (Massachusetts General Hospital and Harvard Medical School)

Research Associate – Triple Negative Breast Cancer (King’s College London)

Postdoctoral Position – Cell Signaling (Columbia University Medical Center)

PhD Position – Early Human Brain Development Modeling with hiPSCs (University of Bonn)

Postdoctoral Fellow – Role of ECM Proteolysis in Normal and Pathological Corneal Repair (UCSF)

Associate Director – Cell Therapy (Stelfox)

PhD Studentship – Cell Migration (MOCA Institute of Molecular and Cellular Anatomy)

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