Volume 6.09 | Mar 12

Extracellular Matrix News 6.09 March 12, 2015
Extracellular Matrix News
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An Injectable Polymer Could Keep Soldiers, Trauma Patients from Bleeding to Death
Researchers have developed a new injectable polymer that strengthens blood clots, called PolySTAT. Administered in a simple shot, the polymer finds any unseen or internal injuries and starts working immediately. [Press release from the University of Washington discussing online prepublication in Science Translational Medicine] Press Release | Abstract
Learn More: UM729, a Novel Small Molecule for Ex Vivo Expansion of Human HSCs
PUBLICATIONS (Ranked by impact factor of the journal)
Predicting Clinical Response to Anticancer Drugs Using an Ex Vivo Platform that Captures Tumor Heterogeneity
Scientists report the engineering of personalized tumor ecosystems that contextually conserve the tumor heterogeneity, and phenocopy the tumor microenvironment using tumor explants maintained in defined tumor grade-matched matrix support and autologous patient serum. [Nat Commun] Full Article

Integrin β1 Controls ​VE-Cadherin Localization and Blood Vessel Stability
By investigating the ​integrin β1-subunit with inducible and endothelial-specific gene targeting in the postnatal mouse retina, researchers showed that ​β1 integrin promoted endothelial sprouting but was a negative regulator of proliferation. In maturing vessels, ​integrin β1 was indispensable for proper localization of ​VE-cadherin and thereby cell-cell junction integrity. [Nat Commun] Abstract

Renal Fibrosis Is Not Reduced by Blocking Transforming Growth Factor-β Signaling in Matrix-Producing Interstitial Cells
While in vitro data suggest that transforming growth factor-β (TGF-β)-induced matrix production is mediated by renal fibroblasts, the role of these cells in TGF-β-dependent tubulointerstitial fibrosis following renal injury is not well defined. To address this, investigators deleted the TGF-β type II receptor in matrix-producing interstitial cells using two different inducible Cre models. [Kidney Int] Abstract

Hypoxia-Mimicking Bioactive Glass/Collagen Glycosaminoglycan Composite Scaffolds to Enhance Angiogenesis and Bone Repair
Resorbable bioactive glass particles with cobalt ions incorporated into the glass network were used to create bioactive glass/collagen-glycosaminoglycan scaffolds optimized for bone tissue engineering. [Biomaterials] Abstract

Precision Assembly of Complex Cellular Microenvironments Using Holographic Optical Tweezers
The authors present a holographic optical tweezers based technology to accurately generate bespoke cellular micro-architectures. Using embryonic stem cells, three-dimensional structures of varying geometries were created and stabilized using hydrogels and cell-cell adhesion methods. [Sci Rep] Full Article | Press Release

Repair of Spinal Cord Injury by Implantation of bFGF-Incorporated HEMA-MOETACL Hydrogel in Rats
Investigators performed experiments to evaluate the synergic effect of implanting hydroxyl ethyl methacrylate trimethylammonium chloride (HEMA-MOETACL) hydrogel incorporated with basic fibroblast growth factor (bFGF) into the site of surgically induced spinal cord injury. Results showed that the bFGF/HEMA-MOETACL transplant provided a scaffold for the ingrowth of regenerating tissue eight weeks after implantation. [Sci Rep] Full Article

Peroxidase Enzymes Regulate Collagen Extracellular Matrix Biosynthesis
The authors report novel findings that show peroxidase enzymes possess a well-conserved profibrogenic capacity to stimulate the migration of fibroblastic cells and promote their ability to secrete collagenous proteins to generate a functional extracellular matrix both in vitro and in vivo. [Am J Pathol] Abstract

Clumps of a Mesenchymal Stromal Cell/Extracellular Matrix Complex Can Be a Novel Tissue Engineering Therapy for Bone Regeneration
Studies are required to develop a mesenchymal stromal cell (MSC) transplant method for bone regeneration because the use of an artificial scaffold restricts the number of transplanted cells and their function. Furthermore, regulating the degree of cell differentiation in vitro is desirable for a more effective regenerative therapy. To address these unresolved issues, with the use of a self-produced extracellular matrix (ECM), scientists developed clumps of an MSC/ECM complex. [Cytotherapy] Abstract

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Synthetic Mimics of the Extracellular Matrix: How Simple Is Complex Enough
The authors focus on recent advances in the development and fabrication of hydrogels and discusses what aspects of extracellular matrix signals can be incorporated to direct cell function in different contexts. [Ann Biomed Eng] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
CPRIT Awards Faculty $11.5 Million for Recruitment and Research in Brain and Bone Cancer, Biology, and Immunotherapy
The Cancer Prevention and Research Institute of Texas (CPRIT) has awarded UT Southwestern Medical Center researchers more than $7.5 million in research grants to improve diagnostic and therapeutic services and research relating to cancers of the brain, breast, throat, and bone, as well as to improve scientific understanding of cancer biology. UT Southwestern received an additional $4 million for recruiting emerging cancer scientists. [UT Southwestern Medical Center] Press Release

Athersys and Chugai Enter License Agreement and Collaboration to Develop MultiStem® Cell Therapy for Ischemic Stroke in Japan
Athersys, Inc. and Chugai Pharmaceutical Co., Ltd. have announced a partnership and license agreement to exclusively develop and commercialize MultiStem® cell therapy for ischemic stroke in Japan. [Athersys, Inc.] Press Release

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Center for Biologics Evaluation and Research (United States)

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Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 2015 World Stem Cell Summit (WSCS15)
December 10-12, 2015
Atlanta, United States

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Postdoctoral Fellow – Role of ECM Proteolysis in Normal and Pathological Corneal Repair (UCSF)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Associate Director – Cell Therapy (Stelfox)

Senior Scientist – Cell Biology CMC (Selvita)

PhD Studentship – Cell Migration (MOCA Institute of Molecular and Cellular Anatomy)

Postdoctoral Position – Fibrosis Research (Boston University School of Medicine)

Postdoctoral Fellow – Tumor Cells in Altered Matrix Environments (Icahn School of Medicine at Mount Sinai)

Director – Vector Production (Sangamo BioSciences, Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

PhD Studentship – Experimental Biophysics (ibidi GmbH)

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