Volume 6.02 | Jan 22

Extracellular Matrix News 6.02 January 22, 2014
Extracellular Matrix News
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Bone Stem Cells Shown to Regenerate Bone and Cartilage in Adult Mice
A stem cell capable of regenerating both bone and cartilage has been identified in bone marrow of mice. The cells, called osteochondroreticular stem cells, were discovered by tracking a protein expressed by the cells. [Press release from Columbia University Medical Center discussing publication in Cell]
Press Release | Abstract | Graphical Abstract | Video
Free Cell Stem Cell Poster: Directed Differentiation of ESCs/iPSCs
PUBLICATIONS (Ranked by impact factor of the journal)
Extracellular Metabolic Energetics Can Promote Cancer Progression
Investigators have identified the extracellular space as an important compartment for malignant energetic catalysis and therapeutic targeting. By functionally screening 661 microRNAs (miRNAs) in parallel during liver colonization, they identified miR-551a and miR-483 as robust endogenous suppressors of liver colonization and metastasis. [Cell] Abstract | Graphical Abstract

Actin-Delimited Adhesion-Independent Clustering of E-Cadherin Forms the Nanoscale Building Blocks of Adherens Junctions
Investigators found that loosely organized clusters of approximately five E-cadherin molecules that form independently of cis or trans interactions, and that are delimited by the cortical F-actin meshwork, are the precursors of trans-ligated adhesive clusters that make up the adherens junction. [Dev Cell]
Abstract | Graphical Abstract | Press Release

Heparan Sulfate Proteoglycans Regulate Fgf Signaling and Cell Polarity during Collective Cell Migration
Analysis of mutations in two exostosin glycosyltransferase genes revealed that loss of heparan sulfate chains results in a failure of collective cell migration due to enhanced fibroblast growth factor (Fgf) ligand diffusion and loss of Fgf signal transduction. [Cell Rep] Full Article | Graphical Abstract

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration
Scientists show that α5β1 integrin undergoes tensin-dependent centripetal movement from the cell periphery to populate adhesions located under the nucleus. From here, ligand-engaged α5β1 integrins are internalized under control of the Arf subfamily GTPase, Arf4, and are trafficked to nearby late endosomes/lysosomes. [Cell Rep] Full Article | Graphical Abstract

Development of a Cellularly Degradable PEG Hydrogel to Promote Articular Cartilage Extracellular Matrix Deposition
A poly (ethylene glycol) (PEG) norbornene hydrogel was functionalized with thiolated transforming growth factor β1 and cross-linked by a matrix metalloproteinase-degradable peptide. Chondrocytes were co-encapsulated with a smaller population of mesenchymal stem cells, with the goal of stimulating matrix production and increasing bulk mechanical properties of the scaffold. [Adv Healthc Mater] Abstract

PDGF-Stimulated Dispersal of Cell Clusters and Disruption of Fibronectin Matrix on 3D Collagen Matrices Requires Matrix Metalloproteinase-2
Previously, researchers reported that under procontractile culture conditions, fibronectin fibrillar matrix assembly by human fibroblasts functioned as a nucleation center for cell clustering on 3D collagen matrices. They now report that switching preformed cell clusters from procontractile to promigratory culture conditions results in cell dispersal out of clusters and disruption of FN matrix. [Mol Biol Cell] Abstract | Full Article

Matrix-Specific Anchors: A New Concept for Targeted Delivery and Retention of Therapeutic Cells
Researchers engineered an artificial collagen-specific anchor (ACSA) that is able to specifically bind collagen I. They demonstrate that, in comparison to the control, the cells expressing the ACSA attached better to collagen I and exhibited improved retention in sites of seeding. [Tissue Eng Part A] Abstract

Incorporation of a Prolyl Hydroxylase Inhibitor into Scaffolds: A Strategy for Stimulating Vascularization
Scientists conjugated the prolyl hydroxylase inhibitor pyridine-2,4-dicarboxylic acid (PDCA) through amide bonds to a gelatin sponge (Gelfoam®). Fibroblasts cultured on PDCA-Gelfoam were able to infiltrate and proliferate in these scaffolds while secreting significantly more vascular endothelial growth factor than cells grown on Gelfoam without PDCA. [Tissue Eng Part A] Abstract

SmartDish™ with STEMgrid™-6 for Accurate Counting of Hematopoietic CFU Assays
The Importance of Extracellular Matrix for Cell Function and In Vivo Likeness
The authors draw special attention to the similarities and differences of current state of the art in vitro and ex vivo models, with special focus on the proteins, cell-cell interactions, and correct matrix composition, which may be a better representative of in vivo conditions in a disease where the extracellular matrix is the central player. [Exp Mol Pathol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Mayland Chang Receives $1.6M American Diabetes Association Research Award
The American Diabetes Association (ADA) announced that it is funding a $1.6 million Accelerator Award to Mayland Chang. Using a mouse model and a novel diagnostic resin that binds to active forms of matrix metalloproteinases (MMPs), Chang’s research group found that MMP-9 may cause diabetic wounds and MMP-8 may be involved in wound repair. [University of Notre Dame] Press Release

Scientists Announce Revolutionary Culturing Technique for Liver and Pancreas
The International Society for Stem Cell Research has awarded Dr. Hans Clevers the society’s McEwen Award for Innovation. His recent papers describe the development of a culturing system for human liver stem cells, as well as stem cells from pancreatic cancer, discoveries with the potential to revolutionize liver transplantation and aid in the fight against pancreatic cancer, respectively. [The International Society for Stem Cell Research (EurekAlert!)] Press Release

Launch of World First Bone Repair Technology Marks Successful First Year for AMBER
AMBER, the Science Foundation Ireland funded materials science center, hosted in Trinity College Dublin, has unveiled a new bone repair technology, which has led to an injured racehorse returning to winning ways after successful jaw reconstruction. [Trinity College Dublin] Press Release

Bone Therapeutics Demonstrates Efficacy in First Patient Cohort in ALLOB® Phase I/IIA Delayed-Union Trial
Bone Therapeutics announced positive efficacy results for the first cohort of four patients enrolled in the Phase I/IIA delayed-union trial with its allogeneic bone-forming cell product ALLOB®. [Bone Therapeutics] Press Release

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NEW Cellular Therapy 2015 – 8th International Symposium on the Clinical Use of Cellular Products
March 19-20, 2015
Erlangen, Germany

NEW 2nd International Congress on Stem Cell and Cellular Therapies (ICSCCT)
October 15-18, 2015
Antalya, Turkey

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Director (California Institute for Regenerative Medicine)

NEW Postdoctoral Fellow – Vascular Bioengineering (University of Pittsburgh)

NEW Postdoctoral Fellow – Cancer Bioengineering and Cancer Biology (University of Minnesota)

PhD Studentship – Cell and Matrix Biology (Cardiff University)

Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

Postdoctoral Training Fellow – Extracellular Matrix Proteomics (Institute of Cancer Research)

Postdoctoral Scientist – Extracellular Matrix and Cell/Tissue Stiffness (University of Pennsylvania)

Postdoctoral Fellow – Integrin Mediated Tumor Invasion and Metastasis (Stony Brook University)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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