Volume 6.00 | Jan 8

Extracellular Matrix News 6.00 January 8, 2015
Extracellular Matrix News
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Conformal Nanopatterning of Extracellular Matrix Proteins onto Topographically Complex Surfaces
Engineering combinatorial surfaces that integrate topographical and biochemical micropatterns enhances control of the biotic-abiotic interface. Investigators used this method to understand cardiomyocyte response to competing physical and chemical cues in the microenvironment. [Nat Methods] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
A Novel Collagen-Nanohydroxyapatite MicroRNA-Activated Scaffold for Tissue Engineering Applications Capable of Efficient Delivery of Both miR-Mimics and antagomiRs to Human Mesenchymal Stem Cells
Scientists introduced the first non-viral, non-lipid platform to date, capable of efficient delivery of mature microRNAs (miRNAs) molecules to human mesenchymal stem cells, a particularly difficult cell type to transfect effectively, with minimal treatment-associated cytotoxicity. [J Control Release] Abstract

Hematopoietic Stem/Progenitor Cells Directly Contribute to Arteriosclerotic Progression via Integrin B2
Investigators demonstrate that Lin-Sca-1+cKit+ (LSK cells) in bone marrow and peripheral blood of LDLr-/- mice on high fat diet expressed significantly more integrin β2, which was responsible for LSK cell adhesion and migration toward ICAM-1 in vitro, and homing to injured arteries in vivo, all of which were blocked with an anti-CD18 blocking antibody. [Stem Cells] Abstract | Full Article

Matrix Metalloproteinase 8 Degrades Apolipoprotein A-I and Reduces Its Cholesterol Efflux Capacity
Researchers investigated whether matrix metalloproteinase-8 affects the structure and antiatherogenic function of apolipoprotein A-I, the main protein component of HDL particles. [FASEB J] Abstract

Influence of Culture Conditions and Extracellular Matrix Alignment on Human Mesenchymal Stem Cells Invasion into Decellularized Engineered Tissues
Investigators explored the influence of insulin and ascorbic acid and extracellular matrix alignment on the recellularization of decellularized engineered tissue by human mesenchymal stem cells. [J Tissue Eng Regen Med] Abstract

Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-β1 Induction of Lung Myofibroblasts
Researchers addressed the role of hyaluronan and its interaction with fibrillar matrix components during myofibroblast formation. Hyaluronan and fibronectin were increased and co-localized in the extracellular matrix following myofibroblast induction by TGF-β1. [Matrix Biol] Abstract

Demineralized Bone Matrix Combined Bone Marrow Mesenchymal Stem Cells, Bone Morphogenetic Protein-2 and Transforming Growth Factor-β3 Gene Promoted Pig Cartilage Defect Repair
Scientists investigated whether a combination of demineralized bone matrix and bone marrow mesenchymal stem cells infected with adenovirus-mediated- bone morphogenetic protein and transforming growth factor-β3 promotes the repair of the full-thickness cartilage lesions in pig model. [PLoS One] Full Article

Electrospun Biomaterial Scaffolds with Varied Topographies for Neuronal Differentiation of Human-Induced Pluripotent Stem Cells
Researchers investigated the effect of micro and nanoscale scaffold topography on promoting neuronal differentiation of human induced pluripotent stem cells and directing the resulting neuronal outgrowth in an organized manner. [J Biomed Mater Res A] Abstract

Functional Impact of Integrin α5β1 on the Homeostasis of Intervertebral Discs: A Study of Mechanotransduction Pathways Using a Novel Dynamic Loading Organ Culture System
Scientists aimed to reflect intervertebral disc (IVD) tissue response to mechanical stress using a dynamic loading organ culture system and to elucidate the functional impact of integrin α5β1 on the pathomechanism of IVD degeneration. [Spine J] Abstract

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Recent Advances in the Study of Zebrafish Extracellular Matrix Proteins
The author highlights recently published data that demonstrate how the extracellular matrix proteins fibronectin, laminin, and collagen contribute to zebrafish development and adult homeostasis. [Dev Biol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Bone Therapeutics Expands Product Portfolio with New Research into Innovative Combined Cell-Matrix Product
Bone Therapeutics announced that it has begun a new research project to investigate novel combined osteoblastic cell-matrix products for the treatment of large bone defects. [Bone Therapeutics S.A.]
Press Release

Osiris Announces a Strategic Partnership with Stryker for Marketing Osiris’ Viable Bone Matrix
Osiris Therapeutics, Inc. announced that it has entered into an exclusive, worldwide partnership with Stryker Corporation for the commercialization and development of Osiris’ viable bone matrix tissue form. [Osiris Therapeutics, Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 4th International Conference on Immunochemotherapy
April 16-17, 2015
Philadelphia, United States

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

NEW Postdoctoral Training Fellow – Extracellular Matrix Proteomics (Institute of Cancer Research)

NEW Postdoctoral Fellow – Breast Cancer Cells Regulation through Extracellular Matrix Cues (Icahn School of Medicine at Mount Sinai)

NEW Postdoctoral Scientist – Extracellular Matrix and Cell/Tissue Stiffness (University of Pennsylvania)

NEW Postdoctoral Fellow – Integrin Mediated Tumor Invasion and Metastasis (Stony Brook University)

NEW Research Associate – Synthetic Collagen Chemist (University of Cambridge)

Postdoctoral Position – Fibrosis Research (Boston University School of Medicine & Boston Medical Center)

Postdoctoral Researcher – Cell-Matrix and Cell-Cell Interactions during Cancer Metastasis and Bacteremia/Sepsis (UCSD)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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