Volume 5.43 | Nov 6

Extracellular Matrix News 5.43 November 6, 2014
Extracellular Matrix News
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Loss of Beta2-Integrin-Mediated Cytoskeletal Linkage Reprograms Dendritic Cells to a Mature Migratory Phenotype
Investigators show that loss of the interaction between beta2-integrins and ​kindlin-3 abolishes the actin-linkage of integrins and the ​GM-CSF receptor in dendritic cells. They observed increased ​GM-CSF responses and increased survival in neutrophils where the interaction between integrin and the cytoskeleton is disrupted.
[Nat Commun]
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PUBLICATIONS (Ranked by impact factor of the journal)
Cerebral Small Vessel Disease-Related Protease HtrA1 Processes Latent TGF-β Binding Protein 1 and Facilitates TGF-β Signaling
Scientists present evidence from mouse brain tissue and embryonic fibroblasts as well as patient skin fibroblasts for a facilitating role of high temperature requirement protein A1 (HtrA1) in transforming growth factor β (TGF-β) pathway activation. They identified latent TGF-β binding protein 1, an extracellular matrix protein and key regulator of TGF-β bioavailability, as a novel HtrA1 target. [Proc Natl Acad Sci USA] Abstract

Cartilaginous Extracellular Matrix-Modified Chitosan Hydrogels for Cartilage Tissue Engineering
Researchers investigated the incorporation of type-II collagen and chondroitin sulfate into injectable chitosan hydrogels designed to gel upon initiation by exposure to visible blue light in the presence of riboflavin. Unmodified chitosan hydrogel supported proliferation and deposition of cartilaginous extracellular matrix by encapsulated chondrocytes and mesenchymal stem cells. [ACS Appl Mater Interfaces] Abstract

Shared Molecular Pathways and Gene Networks for Cardiovascular Disease and Type 2 Diabetes in Women across Diverse Ethnicities
Investigators report that eight top pathways and gene networks related to cardiomyopathy, calcium signaling, axon guidance, cell adhesion, and extracellular matrix appeared to be commonly shared between cardiovascular disease and type 2 diabetes across three ethnic groups. [Circ Cardiovasc Genet] Abstract | Press Release

CLIC4 Regulates Cell Adhesion and β1 Integrin Trafficking
Investigators show that in HeLa and MDA-MB-231 cells, chloride intracellular channel (CLIC) protein CLIC4 knockdown decreases cell-matrix adhesion, cell spreading and integrin signaling, while increasing cell motility. [J Cell Sci] Abstract

Cauda Equina-Derived Extracellular Matrix for Fabrication of Nano-Structured Hybrid Scaffolds Applied to Neural Tissue Engineering
Scientists prepared cauda equina-derived extracellular matrix (ECM) material for producing scaffolds. Cauda equina ECM was blended with poly(l-lactide-co-glycolide) to fabricate nano-structured scaffolds by electrospinning. The incorporation of ECM increased the hydrophilicity of scaffolds. [Tissue Eng Part A] Abstract

Membrane-Induced Structural Rearrangement and Identification of a Novel Membrane Anchor in Talin F2F3
Utilizing a novel membrane mimetic model, researchers present a reproducible model of membrane-bound talin observed across multiple independent simulations. They characterized both local and global membrane-induced structural transitions that successfully reconcile discrepancies between biochemical and structural studies and provide insight into how talin might modulate integrin function. [Biophys J] Abstract

Osteocalcin/Fibronectin-Functionalized Collagen Matrices for Bone Tissue Engineering
Scientists constructed a rhOCN/FNIII9-10 fusion protein and rhOCN/FNIII9-10-functionalized collagen matrices and investigated the potential value for bone tissue engineering. [J Biomed Mater Res A] Abstract

3D Reconstitution of the Patterned Neural Tube from Embryonic Stem Cells
Scientists show that single mouse embryonic stem cells directly embedded in Matrigel or defined synthetic matrices under neural induction conditions can clonally form neuroepithelial cysts containing a single lumen in 3D. [Stem Cell Rep] Full Article | Graphical Abstract | Press Release

Controlling Expansion and Cardiomyogenic Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture
Human pluripotent stem cells expansion as matrix-independent aggregates in suspension culture was combined with cardiomyogenic differentiation using chemical Wnt pathway modulators. [Stem Cell Rep]
Full Article | Graphical Abstract

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Extracellular Matrix Assembly: A Multiscale Deconstruction
The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-specific cell behavior. The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM. [Nat Rev Mol Cell Biol] Abstract

Extracellular Matrix as a Driver for Lung Regeneration
The authors critically examine the role of engineered and native extracellular matrix in tissue and lung regeneration, and provide insights into directions for future research and translation. [Ann Biomed Eng] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

International Society for Matrix Biology (ISMB)
High-Intensity Sound Waves May Aid Regenerative Medicine
Researchers at the University of Washington have developed a way to use sound to create cellular scaffolding for tissue engineering, a unique approach that could help overcome one of regenerative medicine’s significant obstacles. [Press release from the Acoustical Society of America (ASA; Newswise Inc.) discussing research presented at the 168th Meeting of the ASA, Indianapolis] Press Release

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Patent Issued for Substance with Medical Benefits
A novel jelly-like substance developed by Kansas State University researchers was recently issued a U.S. patent. The substance may be used for biomedical applications, ranging from cell culture and drug delivery to repairing and replacing tissue, organs and cartilage. [Kansas State University] Press Release

City of Hope Awarded $8 Million to Launch Stem Cell Therapy Clinic Focused on Fighting Incurable Disease
Identifying cures for currently incurable diseases and providing patients safe, fast, and potentially life-saving treatments is the focus of City of Hope’s new Alpha Clinic for Cell Therapy and Innovation. The clinic is funded by an $8 million, five-year grant from the California Institute for Regenerative Medicine. [City of Hope] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Keystone Symposia – Epigenetics and Cancer
January 25-30, 2015
Keystone, United States

NEW Cell & Gene Therapy Forum 2015
January 26-28, 2015
Washington DC, United States

NEW American Society of Gene & Cell Therapy (ASGCT) 18th Annual Meeting
May 13-16, 2015
New Orleans, United States

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Assistant Professor – Cell-Matrix Manipulation (Eindhoven University of Technology)

NEW Senior Postdoctoral Research Fellow – Biomimetic Tissue Constructs (Johns Hopkins University)

Studentship – Cell Migration (University of East Anglia)

Postdoctoral Fellow – Collaborative Training Program in Musculoskeletal Health Research (Western University)

Postdoctoral Position – Proteases and Extracellular Matrix (GENYO)

Research Associate Position – Skeletal Research Center (Case Western Reserve University)

Postdoctoral Position – Musculoskeletal Genetics (Henry Ford Health System)

Senior Postdoctoral Research Fellow – Biomimetic Tissue Constructs (Johns Hopkins University)

Postdoctoral Position – Matrix Biology (Boise State University)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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