Volume 5.39 | Oct 9

Extracellular Matrix News 5.39 October 9, 2014
Extracellular Matrix News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Interaction of Platelet-Derived Autotaxin with Tumor Integrin αVβ3 Controls Metastasis of Breast Cancer Cells to Bone
Scientists show that autotaxin is stored in α-granules of resting human platelets and released upon tumor cell-induced platelet aggregation, leading to the production of lysophosphatidic acid. [Blood] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Establishing a Gingival Fibroblast Phenotype in a Perfused Degradable Polyurethane Scaffold: Mediation by TGF-β1, FGF-2, β1-Integrin, and Focal Adhesion Kinase
Scientists investigated human gingival fibroblasts interaction within degradable/polar/hydrophobic/ionic polyurethane scaffolds under perfusion by examining the production and the spatial distribution of α-smooth muscle actin and type I collagen, the secretion of transforming growth factor (TGF)-β1 and basic fibroblast growth factor (FGF-2) in the conditioned medium, with a goal of defining the mechanistic pathways affecting the production of these markers in the dynamic culture. [Biomaterials] Abstract

Elevated Autocrine EDIL3 Protects Hepatocellular Carcinoma from Anoikis through RGD-Mediated Integrin Activation
Epidermal growth factor-like repeats and discoidin I-like domains 3 (EDIL3), an extracellular matrix protein with angiogenic and anti-inflammatory effects, is abnormally highly expressed in hepatocellular carcinoma (HCC). Investigators analyzed its expression in liver and HCC tissues and investigated the underliying mechanisms in HCC progression. [Mol Cancer] Abstract | Full Article

Dual Role of the Leukocyte Integrin αMβ2 in Angiogenesis
Researchers investigated the role of β2 integrins in angiogenesis. Angiogenesis was analyzed in wild-type, αM-knockout, and αL-deficient mice using B16F10 melanoma, RM1 prostate cancer, and Matrigel implants. [J Immunol] Abstract

Prostaglandin E2 Stimulates β1-Integrin Expression in Hepatocellular Carcinoma through the EP1 Receptor/PKC/NF-κB Pathway
Scientists investigated the effect of E prostanoid receptor-1 (EP1) receptor activation on β1-integrin expression and cell migration in hepatocellular carcinoma. Cell migration increased by 60% in cells treated with 17-PT-PGE2, which was suppressed by pretreatment with a β1-integrin polyclonal antibody. [Sci Rep] Full Article

Cilengitide Down-Modulates Invasiveness and Vasculogenic Mimicry of Neuropilin-1 Expressing Melanoma Cells through the Inhibition of αvβ5 Integrin
Since the authors had previously identified neuropilin-1 (NRP-1), a co-receptor of vascular endothelial growth factor A, as an important determinant of melanoma aggressiveness, aims of this study were to identify the specific integrins involved in the highly invasive phenotype of NRP-1 expressing cells and to investigate their role as targets to counteract melanoma progression. [Int J Cancer] Abstract

Specific Phosphorylations Transmit Signals from Leukocyte β2- to β1-Integrins and Regulate Adhesion
Investigators elucidated in detail how signals are transmitted from leukocyte-function associated antigen-1 and show that, after its activation, the signaling involves specific phosphorylations of the β2-integrin followed by interactions with cytoplasmic signaling proteins. [J Biol Chem] Abstract | Full Article

Matrix Stiffening and Beta1 Integrin Drive Subtype-Specific Fibroblast Accumulation in Lung Cancer
The mechanical (i.e., matrix rigidity) and soluble mitogenic cues that drive the accumulation of tumor associated fibroblasts from major non-small cell lung cancer subtypes: adenocarcinoma and squamous cell carcinoma were dissected. [Mol Cancer Res] Abstract

Inactivation of AMPK Mediates High Phosphate-Induced Extracellular Matrix Accumulation via NOX4/TGFß-1 Signaling in Human Mesangial Cells
How high phosphate (Pi) levels contribute to extracellular matrix (ECM) accumulation in mesangial cells is unknown. Scientists investigated the role and mechanism of high Pi levels in ECM accumulation in immortalized human mesangial cells. [Cell Physiol Biochem] Full Article

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REVIEWS
Evolving Insights in Cell-Matrix Interactions: Elucidating How Non-Soluble Properties of the Extracellular Niche Direct Stem Cell Fate
The authors summarize the key findings and discuss how insights from two-dimensional biomaterials are being used to examine cellular behaviors in more complex three-dimensional hydrogel systems, in which not only matrix stiffness, but also degradability, plays an important role, and in which defining the nanoscale ligand presentation presents an additional challenge. [Acta Biomater] Full Article

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

International Society for Matrix Biology (ISMB)
 
INDUSTRY NEWS
GW Researcher Receives $2 Million NIH New Innovator Award
Lijie Grace Zhang, an assistant professor, has received a prestigious 2014 Director’s New Innovator Award from the National Institutes of Health (NIH). The award totals $2,287,500. Her five-year project, titled “A Novel 3D Bioprinted Smart Vascularized Nano Tissue,” aims to find a solution for treating large tissue defects in patients. [George Washington University] Press Release

Pitt Researchers Receive $1.25 Million from Defense Department to Make Whole-Eye Transplantation a Reality
University of Pittsburgh School of Medicine researchers have been awarded $1.25 million from the U.S. Department of Defense to fund two projects that aim to establish the groundwork for the nation’s first whole-eye transplantation program. [University of Pittsburgh School of Medicine] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW CIRM Showcase: Accelerating Stem Cell Treatments to Patients
November 5, 2014
San Francisco, United States

NEW Global Controls in Stem Cells
November 5-7, 2014
Singapore, Singapore

Visit our events page to see a complete list of events in the extracellular matrix community.
 
JOB OPPORTUNITIES
NEW Research Associate Position – Skeletal Research Center (Case Western Reserve University)

Postdoctoral Position – Musculoskeletal Genetics (Henry Ford Health System)

Senior Postdoctoral Research Fellow – Biomimetic Tissue Constructs (Johns Hopkins University)

Postdoctoral Position – Matrix Biology (Boise State University)

Postdoctoral Fellow – Diabetes / Kidney Disease / Extracellular Matrix (Vanderbilt University)

Postdoctoral Fellow – Cell Matrix Interactions and Progression of Kidney Disease (F. Hoffmann-La Roche AG)

Postdoctoral Fellow – Cardiac Differentiation of Pluripotent Stem Cells (Stanford University)

Postdoctoral Fellow – Cardiac Animal Surgery (Stanford University)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)


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