Volume 5.37 | Sep 25

Extracellular Matrix News 5.37 September 25, 2014
Extracellular Matrix News
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Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells
Mouse as well as human pancreatic circulating tumor cells exhibit a very high expression of stromal-derived extracellular matrix proteins, including SPARC, whose knockdown in cancer cells suppresses cell migration and invasiveness. [Cell Rep] Full Article | Graphical Abstract | Press Release
SmartDish™ with STEMgrid™-6 for Accurate Counting of Hematopoietic CFU Assays
PUBLICATIONS (Ranked by impact factor of the journal)
miRNA-Based Buffering of the Cobblestone-Lissencephaly-Associated Extracellular Matrix Receptor Dystroglycan via Its Alternative 3′-UTR
Scientists show that in Drosophila the microRNA (miRNA) complex miR-310s acts as an executive mechanism to buffer levels of the muscular dystrophy-associated extracellular matrix receptor ​dystroglycan via its alternative 3′-UTR. [Nat Commun] Full Article

NEDD9/Arf6-Dependent Endocytic Trafficking of Matrix Metalloproteinase 14: A Novel Mechanism for Blocking Mesenchymal Cell Invasion and Metastasis of Breast Cancer
Researchers found that NEDD9 is required for matrix metalloproteinase 14 enzymatic recovery/recycling through the late endosomes to enable disengagement of tissue inhibitor of matrix metalloproteinase 2 and tumor invasion. [Oncogene] Abstract

MicroRNA Mimicry Blocks Pulmonary Fibrosis
The miR-29 family has gained a lot of attention for its clear function in tissue fibrosis. This fibroblast-enriched microRNA (miRNA) family is downregulated in fibrotic diseases which induces a coordinate increase of many extracellular matrix genes. Scientists show that intravenous injection of synthetic RNA duplexes can increase miR-29 levels in vivo for several days. [EMBO Mol Med] Full Article | Press Release

Absence of Fibromodulin Affects Matrix Composition, Collagen Deposition and Cell Turnover in Healthy and Fibrotic Lung Parenchyma
Scientists investigated the role of fibromodulin in healthy and fibrotic lung parenchyma, theorizing that fibromodulin-deficient animals would be protected against fibrosis. [Sci Rep] Full Article

Towards an In Vitro Model Mimicking the Foreign Body Response: Tailoring the Surface Properties of Biomaterials to Modulate Extracellular Matrix
Researchers developed an in vitro model to modulate the host response by tuning biomaterials’ surface properties through surface modifications techniques as a new strategy for tissue regeneration applications. [Sci Rep] Full Article

Arthroscopic Airbrush Assisted Cell Implantation for Cartilage Repair in the Knee: A Controlled Laboratory and Human Cadaveric Study
An airbrush device was used to spray both human expanded osteoarthritic chondrocytes and choncrocytes with their pericellular matrix at 1×106 cells/ml fibrin glue in vitro. Depth-dependent cell viability was assessed for both methods with confocal microscopy. [Osteoarthritis Cartilage] Abstract

Unique Proliferation Response in Odontoblastic Cells Derived from Human Skeletal Muscle Stem Cells by Cytokine-Induced Matrix Metalloproteinase-3
Scientists investigated the effects of cytokine mixture-induced matrix metalloproteinase-3 up-regulation on the proliferation and apoptosis of purified odontoblast-like cells derived from human skeletal muscle stem cells. [Exp Cell Res] Abstract

Dynamics of Telopodes (Telocyte Prolongations) in Cell Culture Depends on Extracellular Matrix Protein
Researchers comparatively investigated, by time-lapse videomicroscopy, the dynamics of telopodes of mouse heart telocytes seeded on collagen, fibronectin, and laminin. [Mol Cell Biochem] Abstract | Full Article

Fluvastatin Attenuated the Effect of Expression of β1 Integrin in PAN-Treated Podocytes by Inhibiting Reactive Oxygen Species
Scientists investigated the effect and mechanism of fluvastatin on the expression of β1 integrin in puromycin aminonucleoside (PAN)-treated podocytes in vitro. [Mol Cell Biochem] Abstract

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Biologic Scaffolds for Regenerative Medicine: Mechanisms of In Vivo Remodeling
The authors review the composition of biologic scaffolds, the methods and recommendations for manufacture, the mechanisms of the biomaterial-host interaction, and the clinical application of this regenerative medicine approach. [Ann Biomed Eng] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Penn Medicine and Wistar Receive $12 Million NCI Melanoma Grant to Help Fast Track Lab Discoveries into Treatments
Penn Medicine and The Wistar Institute have been awarded a prestigious $12.1 million SPORE grant from the National Cancer Institute (NCI). The five-year Specialized Programs of Research Excellence, or SPORE, grant will fund four new melanoma research projects that aim to translate fundamental laboratory discoveries into new therapeutics to treat melanoma and other skin cancers. [Penn Medicine] Press Release

BellBrook Labs and UW-Madison Team Awarded NCI Contract to Develop Next Generation Cancer Models
The National Cancer Institute (NCI) has awarded a $1.75 million Small Business Innovative Research contract to BellBrook Labs for a collaborative effort with researchers at the University of Wisconsin-Madison to develop more realistic models for breast and ovarian cancer. The research will be directed at understanding how the scaffolding that cells attach to, called the extracellular matrix, affects cancer cell growth, motility and response to chemotherapeutic drugs. [BellBrook Labs, LLC (Vocus PRW Holdings, LLC)] Press Release

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National Institutes of Health (United States)

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European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW TERMIS Americas 2014
December 13-16, 2014
Washington D.C., United States

NEW CellTech India 2015
March 2-3, 2015
Bangalore, India

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW PhD Scholarship – Mass Spectrometry-Based Structural Characterization of Cross-Linked Peptides from Extracellular Matrix Proteins (Technical University of Denmark)

NEW Postdoctoral Position – Matrix Biology (Boise State University)

Postdoctoral Fellow – Diabetes / Kidney Disease / Extracellular Matrix (Vanderbilt University)

Postdoctoral Fellow – Cell Matrix Interactions and Progression of Kidney Disease (F. Hoffmann-La Roche AG)

Postdoctoral Fellow – Cardiac Differentiation of Pluripotent Stem Cells (Stanford University)

Postdoctoral Fellow – Cardiac Animal Surgery (Stanford University)

Postdoctoral Position – Proteases and Extracellular Matrix (GENYO)

PhD Position – Biomaterials/Cartilage Regeneration (Peking University)

PhD Student – Bioengineering (George Mason University)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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