Volume 5.35 | Sep 11

Extracellular Matrix News 5.35 September 11, 2014
Extracellular Matrix News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
A Transcriptional Mechanism Integrating Inputs from Extracellular Signals to Activate Hippocampal Stem Cells
Scientists show that when stem cells of the adult hippocampus receive activating signals, they first induce the expression of the transcription factor Ascl1 and only subsequently exit quiescence. Moreover, lowering Ascl1 expression reduces the proliferation rate of hippocampal stem cells, and inactivating Ascl1 blocks quiescence exit completely, rendering them unresponsive to activating stimuli. [Neuron] Full Article | Press Release
SmartDish™ with STEMgrid™-6 for Accurate Counting of Hematopoietic CFU Assays
 
PUBLICATIONS (Ranked by impact factor of the journal)
Connective Tissue Growth Factor and Integrin αvβ6: A New Pair of Regulators Critical for Ductular Reaction and Biliary Fibrosis
Connective tissue growth factor (CTGF) is a matricellular protein that mediates cell-matrix interaction through various subtypes of integrin receptors. Researchers investigated the role of CTGF and integrin αvβ6 in hepatic progenitor/oval cell activation, which often occurs in the form of ductular reactions when hepatocyte proliferation is inhibited during severe liver injury. [Hepatology] Abstract

Age-Associated Reduction of Cellular Spreading/Mechanical Force Up-Regulates Matrix Metalloproteinase-1 Expression and Collagen Fibril Fragmentation via c-Jun/AP-1 in Human Dermal Fibroblasts
Researchers investigated the relationship among fibroblast spreading, mechanical force, matrix metalloproteinase 1 expression, and collagen fibril fragmentation. Reduced fibroblast spreading due to cytoskeletal disruption was associated with reduced cellular mechanical force, as determined by atomic force microscopy. [Aging Cell] Full Article

Cytoplasmic Domain Interactions of Syndecan-1 and Syndecan-4 with α6β4 Integrin Mediate HER2- and EGFR-Dependent Motility and Survival
HER2-dependent haptotactic migration is compared to chemotactic migration stimulated by EGF. Scientists found that whereas HER2-dependent migration depends on syndecan-1, EGF-dependent migration depends on a complex consisting of epidermal growth factor receptor (EGFR), α6β4 and Sdc4. [J Biol Chem]
Abstract | Full Article

Novel Role for Matricellular Proteins in the Regulation of Islet β Cell Survival: The Effect of SPARC on Survival, Proliferation and Signaling
Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein that is important for the regulation of cell growth and adhesion. Researchers investigated the role of SPARC in the regulation of β cell growth and survival. [J Biol Chem] Abstract | Full Article

Scaffold Mean Pore Size Influences Mesenchymal Stem Cell Chondrogenic Differentiation and Matrix Deposition
Researchers investigated whether scaffold mean pore sizes affect mesenchymal stem cell initial attachment, morphology, chondrogenic gene expression and cartilage-like matrix deposition. [Tissue Eng Part A] Abstract

Synergistic Anti-Inflammatory Activity of the Antimicrobial Peptides Human Beta-Defensin-3 (hBD-3) and Cathelicidin (LL-37) in a Three-Dimensional Co-Culture Model of Gingival Epithelial Cells and Fibroblasts
A three-dimensional co-culture model composed of gingival fibroblasts embedded in a collagen matrix overlaid with gingival epithelial cells had a synergistic effect with respect to the secretion of IL-6 and IL-8 in response to lipopolysaccharide stimulation compared to fibroblasts and epithelial cells alone. [PLoS One] Full Article

Human Mesenchymal Stem Cell Osteoblast Differentiation, ECM Deposition, and Biomineralization on PAH/PAA Polyelectrolyte Multilayers
Researchers show that human mesenchymal stromal cells induced with bone differentiation medium to become osteoblasts biomineralize crosslinked polyelectrolyte multilayer built with the polycation poly(allylamine hydrochloride) (PAH) and the polyanion poly(acrylic acid) (PAA). [J Biomed Mater Res A] Abstract

Role of Integrin α2β1 in Mediating Osteoblastic Differentiation on Three-Dimensional Titanium Scaffolds with Submicron-Scale Texture
Scientists tested the potential benefit of combining a submicron-scale textured surface with 3D structure on osteoblast differentiation and the involvement of an integrin-driven mechanism. [J Biomed Mater Res A] Abstract

Membrane-Type I Matrix Metalloproteinase-Dependent Ectodomain Shedding of Mucin16/CA-125 on Ovarian Cancer Cells Modulates Adhesion and Invasion of Peritoneal Mesothelium
Scientists investigated the potential role of membrane type 1 matrix metalloproteinase, a transmembrane collagenase highly expressed in ovarian cancer cells, in Mucin16/cancer antigen 125 (CA-125) ectodomain shedding. [Biol Chem] Abstract

Microarray-Based Detection and Expression Analysis of Extracellular Matrix Proteins in Drug-Resistant Ovarian Cancer Cell Lines
Extracellular matrix (ECM) can influence drug resistance by inhibiting the penetration of the drug into cancer tissue as well as increased apoptosis resistance. Scientists report changes in the ECM and related gene expression pattern in methotrexate-, cisplatin-, doxorubicin-, vincristine-, topotecan- and paclitaxel-resistant variants of the W1 ovarian cancer cell line. [Oncol Rep] Abstract

Free Cell Stem Cell Poster: Directed Differentiation of ESCs/iPSCs
 
REVIEWS
Novel Insights into TRPM7 Function in Fibrotic Diseases: A Potential Therapeutic Target
Fibrosis is the leading cause of organ dysfunction in diseases, which is characterized by an imbalance in the turnover of extracellular matrix components. The authors discuss the comprehensive role of TRPM7 in modulating profibrotic response and its potential as therapeutic target for fibrotic diseases. [J Cell Physiol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
 
INDUSTRY NEWS
BioTime to Collaborate with the University of Wisconsin and Louvain University in Test of HyStem®-Based Hydrogel for Vocal Fold Scarring
BioTime, Inc. announced that it has entered into a collaboration with Susan Thibeault, Ph.D., of the University of Wisconsin and Marc Remacle, M.D. of Louvain University to evaluate BioTime’s proprietary HyStem®-based hydrogel for the treatment of vocal fold scarring. [BioTime, Inc.] Press Release

Cellular Biomedicine Group Launches Clinical Research Study for Cartilage Defect Stem Cell Therapy
Cellular Biomedicine Group Inc. announced the launch of a study on human adipose derived mesenchymal progenitor cell therapy for cartilage defects resulting from osteoarthritis or sports injury. [Cellular Biomedicine Group Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 3rd Annual Cell Culture & Bioprocessing Congress
November 17-18, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the extracellular matrix community.
 
JOB OPPORTUNITIES
NEW PhD Position – Molecular Mechanisms of Cancer Cells and Their Interactions with Surrounding Cells and Tissues (University of Bergen)

Postdoctoral Fellow – Cell Matrix Interactions and Progression of Kidney Disease (F. Hoffmann-La Roche AG)

Postdoctoral Fellow – Cardiac Differentiation of Pluripotent Stem Cells (Stanford University)

Postdoctoral Fellow – Cardiac Animal Surgery (Stanford University)

Postdoctoral Position – Proteases and Extracellular Matrix (GENYO)

PhD Position – Tissue Engineering and Stem Cell Biology (Dublin City University)

PhD Position – Biomaterials/Cartilage Regeneration (Peking University)

PhD Student – Bioengineering (George Mason University)

Postdoctoral Fellow – Roles of Extracellular Matrix in Regulating the Response of Tissues to Injury (University of California – San Francisco)

Postdoctoral Research Associate – 3D Tissue Biology and Modeling (University of Zurich)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)


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