Volume 5.34 | Sep 4

Extracellular Matrix News 5.34 September 4, 2014
Extracellular Matrix News
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Team Discovers New Type of Cell Movement in 3D Matrix
Scientists used an innovative technique to study how cells move in a three-dimensional matrix, similar to the structure of certain tissues, such as the skin. They discovered an entirely new type of cell movement whereby the nucleus helps propel cells through the matrix like a piston in an engine, generating pressure that thrusts the cell’s plasma membrane forward. [Press release from The University of Pennsylvania discussing online prepublication in Science] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Chemokine-Coupled β2 Integrin-Induced Macrophage Rac2-Myosin IIA Interaction Regulates VEGF-A mRNA Stability and Arteriogenesis
Researchers report, in inflammatory monocytes, that the combination of chemokine receptor and adhesion receptor (β2 integrin) engagement leads to an interaction between activated Rac2 and Myosin 9, the heavy chain of Myosin IIA, resulting in augmented vascular endothelial growth factor A (VEGF-A) expression and induction of arteriogenesis. [J Exp Med] Abstract

Nanoscale Integrin Ligand Patterns Determine Melanoma Cell Behavior
In an αVβ3 integrin-dependent fashion, human melanoma cells spread, formed focal contacts, and reorganized cytoskeletal fibers on a physiologically relevant arginine-glycine-aspartic acid density of 349 sites/μm2. [ACS Nano] Abstract

Integrins Regulate Epithelial Cell Differentiation by Modulating Notch Activity
Little is known about the developmental signals that regulate the cell cycle exit-to-differentiation switch. Signals downstream of two key developmental pathways, Notch and Salvador-Warts-Hippo, and of myosin activity regulate this switch during the development of the follicle cell epithelium of the Drosophila ovary. Investigators identified a fourth player, the integrin signaling pathway. [J Cell Sci] Abstract

Enhanced Cell-Induced Articular Cartilage Regeneration by Chondrons; The Influence of Joint Damage and Harvest Site
Chondrons and chondrocytes were isolated from stifle joints of goats in which cartilage damage was surgically induced in the right knee. After four weeks of regeneration culture, DNA content and proteoglycan and collagen content and release were determined. [Osteoarthritis Cartilage] Abstract

Blocking Ligand Occupancy of the αVβ3 Integrin Inhibits the Development of Nephropathy in Diabetic Pigs
Hyperglycemia stimulates secretion of αVβ3 ligands from vascular cells including endothelial cells resulting in activation of the αVβ3 integrin. Researchers determined if blocking ligand occupancy of αVβ3 would inhibit the development of diabetic nephropathy. [Endocrinology] Abstract

CD97 Inhibits Cell Migration in Human Fibrosarcoma Cell by Modulating TIMP-2/MT1-MMP/MMP-2 Activity
Researchers report that CD97 expression in HT1080 fibrosarcoma cells enhanced TIMP-2 secretion, leading to reduced MT1-MMP and MMP-2 activities. This, in turn, impaired cell migration and invasion in vitro and lung macrometastasis in vivo. [FEBS J] Abstract

Single Blastomere Removal from Murine Embryos Is Associated with Activation of Matrix Metalloproteinases and Janus Kinase/Signal Transducers and Activators of Transcription Pathways of Placental Inflammation
Scientists aimed to determine the molecular mechanisms through which placental signaling is deregulated by blastomere removal. Four-cell stage murine embryos produced by in vitro fertilization were subjected to removal of a single blastomere (biopsied) or to the same manipulations without the blastomere removal (controls). [Mol Hum Reprod] Abstract

CCL2 Promotes Integrin-Mediated Adhesion of Prostate Cancer Cells In Vitro
Since chemokine ligand 2 (CCL2) is significantly up-regulated in patients with prostate cancer, researchers assessed whether CCL2 contributes to invasive behavior of prostate cancer cells in vitro. [World J Urol] Abstract

Differential Subcellular and Extracellular Localizations of Proteins Required for Insulin-Like Growth Factor- and Extracellular Matrix-Induced Signaling Events in Breast Cancer Progression
Researchers investigated the prognostic potential of insulin-like growth factor- and extracellular matrix interaction-induced proteins in the early identification of breast cancers with a propensity to metastasize using patient-derived tissue microarrays. [BMC Cancer] Abstract | Full Article

Cell and Matrix Modulation in Prenatal and Postnatal Equine Growth Cartilage, Zones of Ranvier and Articular Cartilage
Samples of the distal radius were collected from prenatal and postnatal equine growth plates, zones of Ranvier and articular cartilage with the aim of identifying Notch signaling components and cells with stem cell-like characteristics and to follow changes in matrix protein localization during joint development. [J Anat] Abstract

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Signaling Complexes at the Cell-Matrix Interface
The structural changes resulting from ligand binding to integrins α5β1, αvβ3 and αIIbβ3 have been mapped in unprecedented detail. The structure of integrin αXβ2 has revealed how ligand binding to the α I domain is transmitted to the rest of the ectodomain. [Curr Opin Struct Biol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

International Society for Matrix Biology (ISMB)
Halozyme’s PEGPH20 Program In Metastatic Pancreatic Cancer Receives Fast Track Designation
Halozyme Therapeutics, Inc. announced that the U.S. Food and Drug Administration has granted Fast Track designation for Halozyme’s program investigating PEGPH20 (PEGylated recombinant human hyaluronidase) in combination with gemcitabine and nab-paclitaxel for the treatment of patients with metastatic pancreatic cancer to demonstrate an improvement in overall survival. [Halozyme Therapeutics, Inc.] Press Release

Boise State Receives $10 Million COBRE Grant from NIH
A $10 million grant over five years from the National Institutes of Health will establish a prestigious Institutional Development Award Center of Biomedical Research Excellence (COBRE) in Matrix Biology at Boise State University. [Boise State University] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Clinical Applications of Stem Cells (CASC) 2015
February 26-27, 2015
Singapore, Singapore

NEW BIT’s 8th Annual World Cancer Congress (WCC-2015)
May 15-17, 2015
Beijing, China

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Postdoctoral Fellow – Cell Matrix Interactions and Progression of Kidney Disease (F. Hoffmann-La Roche AG)

Postdoctoral Fellow – Cardiac Differentiation of Pluripotent Stem Cells (Stanford University)

Postdoctoral Fellow – Cardiac Animal Surgery (Stanford University)

Postdoctoral Position – Proteases and Extracellular Matrix (GENYO)

PhD Position – Tissue Engineering and Stem Cell Biology (Dublin City University)

PhD Position – Biomaterials/Cartilage Regeneration (Peking University)

PhD Student – Bioengineering (George Mason University)

Postdoctoral Fellow – Roles of Extracellular Matrix in Regulating the Response of Tissues to Injury (University of California – San Francisco)

Postdoctoral Research Associate – 3D Tissue Biology and Modeling (University of Zurich)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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