Volume 5.30 | Aug 7

Extracellular Matrix News 5.30 August 7, 2014
Extracellular Matrix News
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Cell Mechanics May Hold Key to How Cancer Spreads and Recurs
Cancer cells that break away from tumors to go looking for a new home may prefer to settle into a soft bed, according to new findings. Researchers found that these so-called tumor-repopulating cells may lurk quietly in stiffer cellular environments, but thrive in a softer space [Press release from the College of Engineering at Illinois discussing online prepublication in Nature Communications] Press Release | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Maturation of GDF15 in Human Placental Trophoblast Cells Depends on the Interaction with Matrix Metalloproteinase-26 (MMP-26)
Scientists aimed to identify the intracellular binding partners of MMP-26, and to investigate how MMP-26 is involved in placentation through the interactions with its partners. [J Clin Endocrinol Metab] Abstract

Naproxen Induces Type X Collagen Expression in Human Bone Marrow Derived Mesenchymal Stem Cells through the Upregulation of 5-Lipoxygenase
Researchers determined the effect of naproxen on type X collagen protein expression and investigated the intracellular signaling pathways that mediate naproxen induced type X collagen gene expression in normal and osteoarthritis mesenchymal stem cells. [Tissue Eng Part A] Abstract

Regeneration of Uterine Horns in Rats Using Collagen Scaffolds Loaded with Human Embryonic Stem Cell-Derived Endometrium-Like Cells
Scientists aimed to efficiently generate endometrium-like cells from human embryonic stem cells and to use these cells with collagen scaffold to repair uterine damage. [Tissue Eng Part A] Abstract

Functional Nucleus Pulposus-Like Matrix Assembly by Human Mesenchymal Stromal Cells Is Directed by Macromer Concentration in Photocrosslinked Carboxymethylcellulose Hydrogels
Researchers evaluated the influence of carboxymethylcellulose macromer concentration on bulk hydrogel properties and nucleus pulposus-like matrix elaboration by human mesenchymal stromal cells. [Cell Tissue Res] Abstract

Low-Intensity Pulsed Ultrasound Activates Integrin-Mediated Mechanotransduction Pathway in Synovial Cells
Scientists examined the mechanotransduction pathway via the integrin/mitogen-activated protein kinase (MAPK) pathway in low-intensity pulsed ultrasound exposure on the synovial membrane cells. A possible integrin/MAPK pathway was examined by immunofluorescence and Western blotting analysis with antibodies targeting specific phosphorylation sites on intracellular signaling proteins. [Ann Biomed Eng] Abstract

Healing of a Xenogeneic Collagen Matrix for Keratinized Tissue Augmentation
Scientists evaluated histologically the healing of a xenogeneic collagen matrix used to augment the width of keratinized tissue around teeth. [Clin Oral Implants Res] Abstract

Viability of Chondrocytes Seeded onto a Collagen I/III Membrane for Matrix-Induced Autologous Chondrocyte Implantation
Researchers aimed to determine the effect of handling the membrane during matrix-induced autologous chondrocyte implantation surgery on the viability of implanted chondrocytes. [J Orthop Res] Abstract

Ureic Clearance Granule, Alleviates Renal Dysfunction and Tubulointerstitial Fibrosis by Promoting Extracellular Matrix Degradation in Renal Failure Rats, Compared with Enalapril
Researchers demonstrate the effects and mechanisms of uremic clearance granules on renal dysfunction and tubulointerstitial fibrosis by regulating extracellular matrix degradation and transforming growth factor-beta1/Smad signaling activity in vivo, compared with enalapril. [J Ethnopharmacol] Abstract

LRP4 Induces Extracellular Matrix Productions and Facilitates Chondrocyte Differentiation
Scientists found that lipoprotein receptor-related protein 4 (LRP4) induced gene expressions of extracellular matrix proteins of type II collagen, aggrecan, and type X collagen, as well as production of total proteoglycans in ATDC5 cells, whereas LRP4 knockdown had opposite effects. [Biochem Biophys Res Commun] Abstract

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Fibroblast Heterogeneity in the Cancer Wound
Cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibiting manner. These pleiotropic functions highlight the inherent plasticity of fibroblasts and may provide new avenues to understand and therapeutically intervene in malignancies. The authors discuss the emerging themes of CAF biology in the context of tumorigenesis and therapy. [J Exp Med] Abstract

Soluble Biglycan as a Biomarker of Inflammatory Renal Diseases
Biglycan, generated by activated macrophages, can enter the circulation and its elevated levels in plasma and renal parenchyma correlate with unfavorable renal function and outcome. The authors focus on the critical role of soluble biglycan in inflammatory signaling in various renal disorders. [Int J Biochem Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

Fraunhofer Life Science Symposium
AMNIOX® Medical Announces Initiation of Prospective, Randomized, Controlled Clinical Study of Chronic Wounds
Amniox Medical, Inc., a developer and marketer of restorative therapies processed from amniotic membrane and umbilical cord, announced the initiation of a randomized, controlled clinical trial of its proprietary product in patients with chronic wounds. [Amniox Medical, Inc. (Business Wire)] Press Release

NIH Awards Imbed Bio a $1.5 Million Grant to Develop Advanced Wound Healing Nanofilm
Imbed Biosciences, Inc. announced that it has been awarded a $1.5 million competitive small business innovation research Phase II grant from National Institute for Arthritis and Musculoskeletal and Skin Diseases, a division of National Institutes of Health (NIH). [Imbed Biosciences, Inc.] Press Release

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Mesenchymal Stem Cells (a Nature Reviews Molecular Cell Biology collaboration).
Request your free copy.
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Clinical Translation of Stem Cell Extracellular Vesicles
November 3-4, 2014
Singapore, Singapore

NEW Matrix Pathobiology, Signaling & Molecular Targets: FEBS Advanced Lecture Course
September 24-25, 2015
Rhodes, Greece

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW PhD Position – Biomaterials/Cartilage Regeneration (Peking University)

NEW PhD Student – Bioengineering (George Mason University)

Postdoctoral Position – Neural Extracellular Matrix (German Center for Neurodegenerative Diseases)

Postdoctoral Fellow – Roles of Extracellular Matrix in Regulating the Response of Tissues to Injury (University of California – San Francisco)

Postdoctoral Research Associate – 3D Tissue Biology and Modeling (University of Zurich)

Research Associate – Embryonic Development and Repair of Basement Membranes (King’s College London)

Postdoctoral Fellow – Mechanisms that Contribute to Metastases of Breast Cancer Cells (Icahn School of Medicine at Mount Sinai)

Postdoctoral Position – Proteases and Extracellular Matrix (GENYO)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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