Volume 5.23 | Jun 19

Extracellular Matrix News 5.23 June 19, 2014
Extracellular Matrix News
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Extracellular Matrix Stiffness and Composition Jointly Regulate the Induction of Malignant Phenotypes in Mammary Epithelium
The authors demonstrate that interpenetrating networks of reconstituted basement membrane matrix and alginate can be used to modulate extracellular matrix (ECM) stiffness independently of composition and architecture. They found that, in normal mammary epithelial cells, increasing ECM stiffness alone induces malignant phenotypes but that the effect is completely abrogated when accompanied by an increase in basement-membrane ligands. [Nat Mater] Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
Factor XIII-A Transglutaminase Promotes Plasma Fibronectin Assembly into Preadipocyte Extracellular Matrix which Modulates Insulin Signaling and Preadipocyte Proliferation and Differentiation
Investigators examined the role of transglutaminase activity and the role of protein crosslinking in adipogenesis. Mouse white adipose tissue and preadipocytes showed abundant transglutaminase activity arising from Factor XIII-A. Factor XIII-A was localized to the cell surface and acted as a negative regulator of adipogenesis by promoting assembly of fibronectin from plasma into preadipocyte extracellular matrix. [Blood] Abstract

The Influence of Extracellular Matrix Composition on the Differentiation of Neuronal Subtypes in Tissue Engineered Innervated Intestinal Smooth Muscle Sheets
Researchers describe the formation of tissue engineered innervated sheets, where intestinal smooth muscle and enteric neuronal progenitor cells are brought into close association in extracellular matrix based microenvironments. [Biomaterials] Abstract

Tranilast, an Orally Active Antiallergic Compound, Inhibits Extracellular Matrix Production in Human Uterine Leiomyoma and Myometrial Cells
Scientists aimed to determine the effect of tranilast (an antiallergic drug known to suppress fibrosis or to stabilize mast cells) on extracellular matrix production in human leiomyoma and myometrial cells. [Fertil Steril] Abstract

A Biocomposite of Collagen Nanofibers and Nanohydroxyapatite for Bone Regeneration
Researchers designed a synthetic construct that mimics the natural bone extracellular matrix through innovative approaches based on simultaneous type I collagen electrospinning and nanophased hydroxyapatite electrospraying using non-denaturating conditions and non-toxic reagents. [Biofabrication] Abstract

Osteoarthritic Cartilage Explants Affect Extracellular Matrix Production and Composition in Cocultured Bone Marrow-Derived Mesenchymal Stem Cells and Articular Chondrocytes
Investigators established a novel in vitro coculture model to evaluate the influence of osteoarthritic (OA) cartilage explants on composition of newly produced matrix and chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells and the phenotype of OA chondrocytes. [Stem Cell Res Ther]
Abstract | Full Article

Morphofunctional Characterization of Decellularized Vena Cava as Tissue Engineering Scaffolds
The authors evaluated different chemical induced decellularization protocols of the inferior vena cava of rabbits. They assessed the remaining extracellular matrix integrity, residual toxicity and the biomechanical resistance of the scaffolds. [Exp Cell Res] Abstract

Over-Expression of Laminin Correlates to Recovery of Vasogenic Edema following Status Epilepticus
Investigators addressed the question of whether the up-regulation of laminin expression represents the astroglio-vascular responses to status epilepticus in an effort to better understand the role of vasogenic edema in epileptogenic insult. [Neuroscience] Abstract

Distinct Functions of the Laminin Beta LN Domain and Collagen IV during Cardiac Extracellular Matrix Formation and Stabilization of Alary Muscle Attachments Revealed by EMS Mutagenesis in Drosophila
Using an EMS mutagenesis screen for cardiac and muscular abnormalities in Drosophila embryos investigators obtained multiple mutants for two genetically interacting complementation groups that showed similar alary muscle and pericardial cell detachment phenotypes. [BMC Dev Biol] Abstract | Full Article

Bone Tissue Engineering with a Collagen-Hydroxyapatite Scaffold and Culture Expanded Bone Marrow Stromal Cells
The authors developed a collagen-hydroxyapatite scaffold that supports consistent osteogenesis by donor-derived osteoprogenitors, and is more easily degraded than a pure ceramic scaffold. They examined the biological performance in vivo in a critical-size mouse calvarial defect. [J Biomed Mater Res B Appl Biomater] Abstract

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Free Cell Stem Cell Poster: Directed Differentiation of ESCs/iPSCs
Collagen I Hydrogels for Bioengineered Tissue Microenvironments: Characterization of Mechanics, Structure, and Transport
This review serves as a resource for selection of fabrication parameters and materials characterization methodologies in order to increase the usefulness of future collagen hydrogel-based characterization studies and tissue engineering experiments. [Tissue Eng Part B Rev] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field
CCRM and Stem Cells Australia Agree to Collaborate in the Global Translation of Stem Cell Research
The Centre for Commercialization of Regenerative Medicine (CCRM) and the Stem Cells Australia consortium have entered into a memorandum of understanding to work together to increase the translation of stem cell research in the two countries. [Stem Cells Australia] Press Release

TxCell Receives Certificate of GMP Compliance for Cell Therapy Manufacturing Facility in France
TxCell SA, a biotechnology company developing innovative, personalized cell-based immunotherapies using antigen specific regulatory T-cells for severe chronic inflammatory and autoimmune diseases, announced that it has been granted Certificate of Good Manufacturing Practice (GMP) compliance for its cell therapy manufacturing facility in Besançon, France. [TxCell SA] Press Release

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Therapeutic Goods Administration (Australia)
NEW Get Connected 4: Cellular Microenvironment
September 10-12, 2014
Manchester, United Kingdom

NEW The World Stem Cell Summit 2014
December 3-5, 2014
San Antonio, United States

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Research Assistant – Studying Cell-Matrix Interactions by Advanced Imaging Methods (Mechanobiology Institute)

NEW Scientist – Skin Cell Research (STEMCELL Technologies Inc.)

NEW Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

NEW Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Independent Junior Research Group Leader – Biophysical Aspects of Cell Dynamics, Cell-Cell and/or Cell-Matrix Interactions (Cells in Motion)

Research Associate – Tissue Systems (University of Manchester)

Postdoctoral Associate – Mechanisms of Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF) on Extracellular Matrix (University of Minnesota – Twin Cities)

PhD Research Fellow – Cellular Interactions with the Extracellular Matrix of Tumor Microenvironment (Norwegian University of Science and Technology)

Postdoctoral Position – Proteases and Extracellular Matrix (GENYO)

Postdoctoral Position – 3D Structured Engineered Tissues (Nano Fiber Matrices B.V.)

Postdoctoral Position – Therapeutic Advantages of the Combined Use of Scaffold and Cells for Orthopedic Applications (Bone Therapeutics S.A.)

PhD Position – 3D Structured Self-Assembled Hydrogels for Tissue Engineering (TU Delft)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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