Volume 5.18 | May 15

Extracellular Matrix News 5.18 May 15, 2014
Extracellular Matrix News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Dynamic Decellularization and Cross-Linking of Rat Tracheal Matrix
Researchers present the characterization of rat tracheae decellularized in dynamic conditions, implementing a detergent-enzymatic method, previously considered. Only six cycles were enough to generate a tracheal matrix that was histologically and structurally similar to the native one. [Biomaterials] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Post-Transcriptional Regulation in Osteoblasts Using Localized Delivery of miR-29a Inhibitor from Nanofibers to Enhance Extracellular Matrix Deposition
Investigators hypothesized that gelatin nanofibers could be used for the localized transient delivery of miRNA-based therapeutics, using miR-29a inhibitor as a prototype to increase extracellular matrix deposition. [Acta Biomater] Abstract

Periostin Secreted by Mesenchymal Stem Cells Supports Tendon Formation in an Ectopic Mouse Model
Scientists hypothesized that during tendon cell differentiation secreted factors involved in extracellular matrix formation exert a major impact on tendon development. [Stem Cell Dev] Abstract

Matrix Metalloproteinase-27 Is Expressed in CD163+/ CD206+ M2 Macrophages in the Cycling Human Endometrium and in Superficial Endometriotic Lesions
Researchers investigated the expression and cellular localization of matrix metalloproteinases (MMP)-27 in the cycling human endometrium and in endometriotic lesions. MMP-27 mRNA was detected throughout the menstrual cycle. [Mol Hum Reprod] Abstract

Matrix Metalloproteinase-9 Null Mice Are Resistant to TGF-β-Induced Anterior Subcapsular Cataract Formation
Investigators used two matrix metalloproteinase (MMP)-2 and MMP-9 knockout mice to determine their unique roles in transforming growth factor (TGF)-β-induced anterior subcapsular cataract formation. [Am J Pathol] Abstract

Detection of Extracellular Matrix Degradation in Intervertebral Disc Degeneration by Diffusion Magnetic Resonance Spectroscopy
Fresh bovine intervertebral discs were injected with papain solution to induce extracellular matrix (ECM) degradation. The apparent diffusion coefficients, T2 values, and contents of ECM macromolecules and water resonances were measured longitudinally in the nucleus pulposus. [Magn Reson Med] Abstract

Tight Skin 2 Mice Exhibit a Novel Time Line of Events Leading to Increased Extracellular Matrix Deposition and Dermal Fibrosis
Researchers report that tight skin 2/+ mice develop excess dermal fibrosis with age, as skin is not significantly fibrotic until 10 weeks, a full eight weeks after the development of the physical tight skin phenotype. [Matrix Biol] Full Article

Spatiotemporal Mapping of Matrix Remodeling and Evidence of In Situ Elastogenesis in Experimental Abdominal Aortic Aneurysms
Spatiotemporal changes in the extracellular matrix were studied within abdominal aortic aneurysms (AAAs) generated in rats via elastase infusion. At 7, 14 and 21 days post-induction, AAA tissues were divided into proximal, mid- and distal regions, based on their location relative to the renal arteries and the region of maximal aortic diameter. [J Tissue Eng Regen Med] Abstract

Berberine Exposure Triggers Developmental Effects on Planarian Regeneration
The authors report the effects of berberine on regeneration in the planarian Dugesia japonica. Their findings demonstrate that this compound perturbs the regenerative pattern. By real-time PCR screening for the effects of berberine exposure on gene expression, they identified alterations in the transcriptional profile of genes representative of different tissues, as well as of genes involved in extracellular matrix remodeling. [Sci Rep]
Full Article

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REVIEWS
Matricryptins and Matrikines: Biologically Active Fragments of the Extracellular Matrix
The authors define matrikines and matricryptins, which are bioactive fragments released from the extracellular matrix proteins, proteoglycans and glycosaminoglycans, and report their major biological activities. [Exp Dermatol] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

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INDUSTRY NEWS
Taxus Cardium’s Excellagen® Selected for Use with Stem Cells in EU-Funded Human Clinical Study
Taxus Cardium Pharmaceuticals Group Inc. announced that the company’s Excellagen® flowable dermal matrix in combination with Orbsen Therapeutics’ mesenchymal stromal stem cell therapy Cyndacel-M™ has been selected for clinical evaluation in a Phase Ib safety study for the potential treatment of chronic diabetic wounds to be funded by the European Union under EU Framework 7. [Taxus Cardium Pharmaceuticals Group Inc.]
Press Release

Giants of the Cytoskeleton Win E.B. Wilson Medal
William “Bill” Brinkley of the Baylor College of Medicine in Houston, John Heuser of the Washington University School of Medicine in St. Louis, and Peter Satir of the Albert Einstein College of Medicine in the Bronx identified crucial pieces of the cytoskeleton and showed how these elements drive life at the cellular level. [American Society for Cell Biology] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Stem Cell Meeting on the Mesa
October 7-9, 2014
La Jolla, United States

Visit our events page to see a complete list of events in the extracellular matrix community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Cell and Extracellular Matrix Biology (Johns Hopkins University)

Postdoctoral Research Fellow – Agents that Promote Extracellular Matrix Production on Tendon Healing (Georgia Institute of Technology)

PhD Studentship – 3D Printing of Hydrogel Scaffolds for 3D Dependent Cell Culture (Technical University of Denmark)

Postdoctoral Fellow – How Breast Cancer Cells Regulate Anchorage-Independent Survival to Overcome Anoikis (Icahn School of Medicine at Mount Sinai)

Postdoctoral Position – 3D Structured Engineered Tissues (Nano Fiber Matrices B.V.)

PhD Position – Patterned Biomaterial Degradation to Guide Cell Response, Extracellular Matrix Deposition and In Vivo Tissue Regeneration (Universitaetsmedizin Berlin)

Postdoctoral Position – Extracellular RNA Bioinformatics and Biology (University of California, Los Angeles)

Postdoctoral Fellow – Cell Biology, Protein Trafficking, Kidney Physiology (Harvard Medical School)

Postdoctoral Position – Macromolecule Stabilization (University of Minnesota)

Postdoctoral Position – Therapeutic Advantages of the Combined Use of Scaffold and Cells for Orthopedic Applications (Bone Therapeutics S.A.)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

PhD Position – 3D Structured Self-Assembled Hydrogels for Tissue Engineering (TU Delft)

Research Technologist – hPSC (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)


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