Volume 5.16 | May 1

Extracellular Matrix News 5.16 May 1, 2014
Extracellular Matrix News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Regenerative Medicine Improves Muscle Strength and Function in Leg Injuries
Damaged leg muscles grew stronger and showed signs of regeneration in three out of five men whose old injuries were surgically implanted with extracellular matrix derived from pig bladder, according to a new study. [Press release from the University of Pittsburgh School of Medicine discussing online prepublication in Science Translational Medicine] Press Release | Abstract
Brain Food: NeuroCult SM1 for Long-Term Primary Neuronal Culture. View Data!
 
PUBLICATIONS (Ranked by impact factor of the journal)
Large, Stratified, and Mechanically Functional Human Cartilage Grown In Vitro by Mesenchymal Condensation
Researchers report that clinically sized pieces of human cartilage with physiologic stratification and biomechanics can be grown in vitro by recapitulating some aspects of the developmental process of mesenchymal condensation. [Proc Natl Acad Sci USA] Abstract | Press Release

Altered Bone Material Properties in HLA-B27 Rats Include Reduced Mineral to Matrix Ratio and Altered Collagen Cross-Links
Investigators determined that in the HLA-B27 rat, an animal susceptible to both alveolar bone loss (ABL) and long bone osteopenia, there is a statistically significant negative correlation between ABL and long bone BMD, as well as mineral/matrix ratio at actively bone forming trabecular surfaces [J Bone Miner Res] Abstract

Cardiac Differentiation of Cardiosphere-Derived Cells in Scaffolds Mimicking Morphology of the Cardiac Extracellular Matrix
Towards elucidating the relationship between extracellular matrix (ECM) properties and cardiac differentiation, researchers created an in vitro model based on ECM-mimicking fibers and a type of cardiac progenitor cell, cardiosphere-derived cells. [Acta Biomater] Abstract

Cationic Surface Charge Combined with Either Vitronectin or Laminin Dictates the Evolution of hESC/Microcarrier Aggregates and Cell Growth in Agitated Cultures
Scientists describe an innovative technology, consisting of a cationic charge that underlies the extracellular matrix (ECM) coatings. By combining poly-L-lysine with a coating of ECM protein, cell attachment efficiency and cell spreading are improved, thus enabling seeding under agitation in a serum-free medium. [Stem Cells Dev] Abstract

Sub-Toxic Nicotine Concentrations Affect Extracellular Matrix and Growth Factor Signaling Gene Expressions in Human Osteoblasts
Investigators examined the effects of exposure to a single or multiple sub-toxic nicotine concentrations on human osteoblasts. Cell growth and expression of genes involved in bone differentiation, extracellular matrix metabolism, and growth factor signaling pathways were investigated in nicotine-treated cells compared to untreated cells. [J Cell Physiol] Abstract

Novel Collagen Membranes for the Reconstruction of the Corneal Surface
Investigators analyzed the suitability and biocompatibility of defined noncross-linked and UV/riboflavin cross-linked equine type I collagen membranes for the reconstruction of the corneal surface. [Tissue Eng Part A] Abstract

Decreased Proliferative Capacity of Aged Dermal Fibroblasts in a Three Dimensional Matrix Is Associated with Reduced IGF1R Expression and Activation
Scientists determined if expression and activation of IGF1R in aged human dermal fibroblasts, when compared to young fibroblasts, is associated with altered proliferative capacity in a 3D collagen matrix that better simulates the dermal extracellular matrix in vivo. [Biogerontology] Abstract

Osteochondral Regeneration Using an Oriented Nanofiber Yarn-Collagen Type I/Hyaluronate Hybrid/TCP Biphasic Scaffold
An oriented poly(L-lactic acid)-co-poly(ε-caprolactone)/collagen type I (Col-I) nanofiber yarn mesh, fabricated by dynamic liquid electrospinning served as a skeleton for a freeze-dried Col-I/hyaluronate (HA) chondral phase to enhance the mechanical strength of the scaffold. In vitro results show that the Yarn Col-I/HA hybrid scaffold can allow the cell infiltration like sponge scaffolds. [J Biomed Mater Res A] Abstract

Photopolymerizable Chitosan-Collagen Hydrogels for Bone Tissue Engineering
Researchers developed a composite hydrogel consisting of photocrosslinkable methacrylated glycol chitosan and semi-interpenetrating collagen with a riboflavin photoinitiator under blue light. [J Tissue Eng Regen Med] Abstract

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REVIEWS
Contributions of Chondroitin Sulfate Proteoglycans to Neurodevelopment, Injury, and Cancer
Three distinct modes of migration mediation result from the relative abundance and positioning of expressed chondroitin sulfate proteoglycans (CSPGs), the profile of CSPG receptors expressed by the motile cell types, and the overall way in which the CSPGs integrate into and stabilize the neural extracellular matrix. The authors discuss recent findings that help to clarify the molecular mechanisms that underlie these distinct migration-regulating properties as they pertain to neural development, CNS injury, and gliomagenesis. [Curr Opin Neurobiol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

International Society for Matrix Biology (ISMB)
 
INDUSTRY NEWS
Orbsen Therapeutics in €6 Million Research Funding Success
Orbsen Therapeutics is a spin-out from NUI Galway’s Regenerative Medicine Institute. MERLIN (MEsynchymal stem cells to Reduce Liver INflammation) will advance Orbsen’s proprietary cell therapy to a Phase IIa clinical trial in patients with inflammatory liver disease. [NUI Galway] Press Release

Advanced Cell Technology’s Chief Scientific Officer Dr. Robert Lanza Named One of TIME Magazine’s 100 Most Influential People in the World
Advanced Cell Technology, Inc. announced that the company’s Chief Scientific Officer, Robert Lanza, MD, has been selected for the 2014 TIME 100 annual list of the hundred most influential people in the world. [Advanced Cell Technology, Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Tissue Engineering Congress 2014
June 2-4, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the extracellular matrix community.
 
JOB OPPORTUNITIES
NEW PhD Studentship – 3D Printing of Hydrogel Scaffolds for 3D Dependent Cell Culture (Technical University of Denmark)

NEW Research Technologist – hPSC (STEMCELL Technologies Inc.)

Postdoctoral Fellow – How Breast Cancer Cells Regulate Anchorage-Independent Survival to Overcome Anoikis (Icahn School of Medicine at Mount Sinai)

Postdoctoral Position – 3D Structured Engineered Tissues (Nano Fiber Matrices B.V.)

PhD Position – Patterned Biomaterial Degradation to Guide Cell Response, Extracellular Matrix Deposition and In Vivo Tissue Regeneration (Universitaetsmedizin Berlin)

Postdoctoral Position – Extracellular RNA Bioinformatics and Biology (University of California, Los Angeles)

Postdoctoral Fellow – Cell Biology, Protein Trafficking, Kidney Physiology (Harvard Medical School)

Postdoctoral Position – Macromolecule Stabilization (University of Minnesota)

Postdoctoral Position – Therapeutic Advantages of the Combined Use of Scaffold and Cells for Orthopedic Applications (Bone Therapeutics S.A.)

Postdoctoral Research Associate – Extracellular Microenvironment in Cancer (Institute of Translational Medicine, University of Liverpool)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

PhD Position – 3D Structured Self-Assembled Hydrogels for Tissue Engineering (TU Delft)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)


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