Volume 5.14 | Apr 17

Extracellular Matrix News 5.14 April 17, 2014
Extracellular Matrix News
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A Novel Poly(Amido Amine)-Dendrimer-Based Hydrogel as a Mimic for the Extracellular Matrix
The extracellular matrix is mimicked by a novel dendrimer-based hydrogel, which exhibits a highly interconnected porous network, enhanced mechanical stiffness, and a low swelling ratio. The hydrogel system supports the proliferation and differentiation of mesenchymal stem cells without any cytotoxic effects. [Adv Mater] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
In Vivo Osteogenic Differentiation of Human Turbinate Mesenchymal Stem Cells in an Injectable In Situ-Forming Hydrogel
To examine osteogenic differentiation of human turbinate mesenchymal stromal cells (hTMSCs) in vivo in an injectable hydrogel, cells were incorporated into a methoxy polyethylene glycol-polycaprolactone block copolymer (MP) solution simply by mixing. hTMSC-loaded MP solutions formed a hydrogel almost immediately upon injection into animals and the cells remained viable, even after 12 weeks. [Biomaterials] Abstract

Micromolded Gelatin Hydrogels for Extended Culture of Engineered Cardiac Tissues
Because collagen is the primary extracellular matrix protein in the heart, the authors hypothesized that micromolded gelatin hydrogel substrates tuned to mimic the elastic modulus of the heart would extend the lifetime of engineered cardiac tissues by better matching the native chemical and mechanical microenvironment. [Biomaterials] Abstract

Culture Dimensionality Influences the Resistance of Glioblastoma Stem-Like Cells to Multikinase Inhibitors
Scientists studied the effects of substrate properties including elasticity, dimensionality and matrix composition on the response of glioblastoma stem-like cells to chemotherapeutic agents. [Mol Cancer Ther] Abstract

Endothelial Cells Enhance the In Vivo Bone-Forming Ability of Osteogenic Cell Sheets
Monoculture osteogenic cell sheets (CSs) were stacked on top of homotypic or heterotypic CSs, and subcutaneously implanted in the dorsal flap of nude mice for seven days. The implants showed mineralized tissue formation under both conditions. [Lab Invest] Abstract

Matrix Rigidity-Modulated Cardiovascular Organoid Formation from Embryoid Bodies
Using collagen-conjugated polyacrylamide hydrogels with controlled elastic moduli, investigators discovered that cellular organization in a form of vascularized cardiac muscle sheet was maximal on the gel with the stiffness similar to cardiac muscle. [PLoS One] Full Article

Dual Contribution of MAPK and PI3K in Epidermal Growth Factor-Induced Destabilization of Thyroid Follicular Integrity and Invasion of Cells into Extracellular Matrix
Mitogen activated protein kinase (MAPK)/extracellular-regulated kinase kinase inhibition by U0126 only partially antagonized epidermal growth factor/serum-induced cell migration from the basal follicular surface into the matrix. Combined treatment with U0126 and LY294002, a phosphoinositide-3 kinase (PI3K) blocker, was necessary to abolish migration. [Exp Cell Res] Abstract

Ultrafine Fibrous Gelatin Scaffolds with Deep Cell Infiltration Mimicking 3D ECMs for Soft Tissue Repair
Ultrafine fibrous scaffolds with deep cell infiltration and sufficient water stability have been developed from gelatin, aiming to mimic the extracellular matrices (ECMs) as three dimensional (3D) stromas for soft tissue repair. [J Mater Sci Mater Med] Abstract

Regeneration of Aplysia Bag Cell Neurons Is Synergistically Enhanced by Substrate-Bound Hemolymph Proteins and Laminin
The authors investigated Aplysia hemolymph as a source of endogenous factors to promote regeneration of bag cell neurons. They describe a novel synergistic effect between substrate-bound hemolymph proteins and laminin. [Stem Cell Rep] Full Article

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Rare Bone Diseases and Their Dental, Oral, and Craniofacial Manifestations
Discussed are defects in four key physiologic processes in bone/tooth formation that serve as models for the understanding of other diseases in the skeleton and dental-oral-craniofacial complex: progenitor cell differentiation (fibrous dysplasia), extracellular matrix production (osteogenesis imperfecta), mineralization (familial tumoral calcinosis/hyperostosis hyperphosphatemia syndrome, hypophosphatemic rickets, and hypophosphatasia), and bone resorption (Gorham-Stout disease). [J Dent Res] Abstract | Press Release

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Collagen Matrix, Inc. Receives FDA 510(k) Clearance of a Flexible Collagen Nerve Conduit for Reduction of Painful Neuroma Formation
Collagen Matrix, Inc. announced that it has received FDA’s 510(k) clearance of its Flexible Collagen Nerve Conduit for management of peripheral nerve injuries at nerve ends in the foot to reduce the formation of painful neuroma. [PR Newswire Association LLC] Press Release

Akron Biotech Awarded SBIR Grant for Development of Novel Method to Isolate Adipose Derived Stem Cells
Akron Biotech announced it was awarded a Phase I Small Business Innovative Research (SBIR) Award from the National Institutes of Health to develop enzyme-based formulations for the isolation of stem cells from various tissues. The Phase I project proposes an alternative to develop and use optimal formulations of a family of novel engineered enzymes capable of catalyzing the degradation of virtually all extracellular matrix components, with the goal of liberating viable stem cells with good and stable proliferative capabilities. [Akron Biotech]
Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe Chapter Meeting 2014
June 10-13, 2014
Genoa, Italy

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Postdoctoral Position – 3D Structured Engineered Tissues (Nano Fiber Matrices B.V.)

PhD Position – Patterned Biomaterial Degradation to Guide Cell Response, Extracellular Matrix Deposition and In Vivo Tissue Regeneration (Universitaetsmedizin Berlin)

Postdoctoral Position – Extracellular RNA Bioinformatics and Biology (University of California, Los Angeles)

Postdoctoral Researcher – Signaling Mechanisms of GPCRs and Wnts and Their In Vivo Functions (Yale University)

Postdoctoral Fellow – Cell Biology, Protein Trafficking, Kidney Physiology (Harvard Medical School)

Postdoctoral Position – Macromolecule Stabilization (University of Minnesota)

Postdoctoral Position – Therapeutic Advantages of the Combined Use of Scaffold and Cells for Orthopedic Applications (Bone Therapeutics S.A.)

Postdoctoral Research Associate – Extracellular Microenvironment in Cancer (Institute of Translational Medicine, University of Liverpool)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

PhD Position – 3D Structured Self-Assembled Hydrogels for Tissue Engineering (TU Delft)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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