Volume 5.13 | Apr 10

Extracellular Matrix News 5.13 April 10, 2014
Extracellular Matrix News
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Biologically-Active Laminin-111 Fragment that Modulates the Epithelial-to-Mesenchymal Transition in Embryonic Stem Cells
The authors report a biologically-active laminin-111 fragment generated by matrix metalloproteinase 2 (MMP2) processing, which is highly up-regulated during differentiation. They showed that the β1-chain-derived fragment interacts via α3β1-integrins, thereby triggering the down-regulation of MMP2 in mouse and human embryonic stem cells. [Proc Natl Acad Sci USA] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Mechanotransduction via p190RhoGAP Regulates a Switch between Cardiomyogenic and Endothelial Lineages in Adult Cardiac Progenitors
Scientists showed that mechanical cues can instruct c-Kit+ cell differentiation along two lineages with corresponding morphogenic changes, while also serving to amplify the initial c-Kit+ sub-population. In particular, mechanical cues mimicking the structure of myocardial extracellular matrix specify cardiomyogenic fate, while cues mimicking myocardium rigidity specify endothelial fates. [Stem Cells] Abstract | Full Article

pH-Responsive Polymer-Liposomes for Intracellular Drug Delivery and Tumor Extracellular Matrix Switched-On Targeted Cancer Therapy
Investigators present a tumor-extracellular matrix pH-induced targeting liposome crosslinked from methoxy-poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide-co-histidine)-cholesterol copolymers and biotin2-polyethylene glycol crosslinkers by hydrogen bonds to overcome the defects of liposomes. [Biomaterials] Abstract

Chondrogenic Differentiation of Adipose-Derived Stromal Cells in Combinatorial Hydrogels Containing Cartilage Matrix Proteins with Decoupled Mechanical Stiffness
Researchers report the development of an extracellular matrix (ECM)-containing hydrogel platform with largely decoupled biochemical and mechanical cues by modulating the degree of methacrylation of ECM molecules. [Tissue Eng Part A] Abstract

Matrix Composition and Mechanics Directs Pro-Angiogenic Signaling from Mesenchymal Stem Cells
Researchers showed how controlling the mechanical properties and protein composition of the extracellular matrix surrounding mesenchymal stem cells can guide pro-angiogenic signaling. [Tissue Eng Part A] Abstract

Cross-Linking of Collagen I by Tissue Transglutaminase Provides a Promising Biomaterial for Promoting Bone Healing
Scientists demonstrated that the cross-linking of collagen I by tissue transglutaminase causes an alteration in the morphology and rheological properties of the collagen fibers. Human osteoblasts attach, spread, proliferate, differentiate and mineralize more rapidly on this cross-linked matrix compared to native collagen. [Amino Acids] Abstract

Expansion on a Matrix Deposited by Nonchondrogenic Urine Stem Cells Strengthens the Chondrogenic Capacity of Repeated-Passage Bone Marrow Stromal Cells
Investigators found that the extracellular matrix (ECM) deposited by human urine-derived stem cells (hUSCs) (UECM) can greatly recharge repeated-passage hBMSCs toward chondrogenic differentiation, a result that might be explained by trophic factors released from hUSCs being immobilized in UECM. [Cell Tissue Res] Abstract

Artificial Matrices with High-Sulfated Glycosaminoglycans and Collagen Are Anti-Inflammatory and Pro-Osteogenic for Human Mesenchymal Stromal Cells
The influence of artificial extracellular matrices on the interleukin-1β-induced pro-inflammatory response of human mesenchymal stromal cells was studied. [J Cell Biochem] Abstract

Short Laminin Peptide for Improved Neural Stem Cell Growth
The authors developed a novel peptide sequence with only 12 amino acids based on the Ile-Lys-Val-Ala-Val, or IKVAV, sequence: Ac-Cys-Cys-Arg-Arg-Ile-Lys-Val-Ala-Val-Trp-Leu-Cys. This short peptide sequence, similar to tissue-derived full laminin molecules, supported human neural stem/progenitor cells to attach and proliferate to confluence for continuous passage and subculture. [Stem Cells Transl Med] Abstract

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Electrospinning for Regenerative Medicine: A Review of the Main Topics
The process of electrospinning was examined, providing a description of the common techniques used for the physicochemical and biological characterization of electrospun fibers. The review also discusses the potential applications of electrospun scaffolds for tissue engineering, based on scientific literature. [Drug Discov Today] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field
Researchers Find that Renal Cancer Cells Thrive when Put in the Right Environment and Supported by a Specific Enzyme
Researchers found renal cancer cells planted in a supportive environment proliferate with the help of an enzyme usually only seen in the brain. The enzyme, a specific isoform of a rather common kinase, may eventually become a target for cancer therapy as kinases constitute reasonably targetable enzymes. [Press release from the Fox Chase Cancer Center discussing research presented at the annual meeting of the American Association for Cancer Research (AACR) 2014, San Diego] Press Release

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American CryoStem and Rutgers University File Joint Patent on Adipose-Derived Stem Cell Platform Technology
American CryoStem Corporation announced that the company has filed its first jointly-owned patent application with its research partners at Rutgers University titled, “Nanoparticle-Mediated Synthetic Transcription Factor for Enhanced Gene Regulation and Cell Differentiation.” [American CryoStem Corporation] Press Release

Dr. Mahendra Rao Joins NYSCF as VP for Regenerative Medicine
Dr. Mahendra Rao, who has directed the Center for Regenerative Medicine at the National Institutes of Health since 2010, will join The New York Stem Cell Foundation (NYSCF) Research Institute as its Vice President for Regenerative Medicine, a newly created position. [The New York Stem Cell Foundation] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Future Investigators of Regenerative Medicine (FIRM) Symposium 2014
September 8-11, 2014
Girona, Spain

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW PhD Position – Patterned Biomaterial Degradation to Guide Cell Response, Extracellular Matrix Deposition and In Vivo Tissue Regeneration (Universitaetsmedizin Berlin)

Postdoctoral Position – Extracellular RNA Bioinformatics and Biology (University of California, Los Angeles)

Postdoctoral Researcher – Signaling Mechanisms of GPCRs and Wnts and Their In Vivo Functions (Yale University)

Postdoctoral Fellow – Cell Biology, Protein Trafficking, Kidney Physiology (Harvard Medical School)

Postdoctoral Position – Macromolecule Stabilization (University of Minnesota)

Postdoctoral Position – Therapeutic Advantages of the Combined Use of Scaffold and Cells for Orthopedic Applications (Bone Therapeutics S.A.)

Postdoctoral Research Associate – Extracellular Microenvironment in Cancer (Institute of Translational Medicine, University of Liverpool)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

PhD Position – 3D Structured Self-Assembled Hydrogels for Tissue Engineering (TU Delft)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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