Volume 5.12 | Apr 3

Extracellular Matrix News 5.12 April 3, 2014
Extracellular Matrix News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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Combined Hydrogels that Switch Human Pluripotent Stem Cells from Self-Renewal to Differentiation
The conditions required for self-renewal vs. differentiation of human pluripotent stem cells are different, and a single system that efficiently achieves both outcomes is not available. Investigators addressed this dual need by developing a hydrogel-based material that uses ionic de-cross-linking to remove a self-renewal permissive hydrogel (alginate) and switch to a differentiation-permissive microenvironment (collagen). [Proc Natl Acad Sci USA] Abstract | Full Article | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
Cancer-Associated Fibroblasts Regulate the Plasticity of Lung Cancer Stemness via Paracrine Signaling
Investigators established a sustainable primary culture of Oct3/4+/Nanog+ lung cancer stem cells fed with CD90+ cancer-associated fibroblasts to further advance the knowledge of preserving stem cells in the tumor microenvironment. [Nat Commun] Abstract

Transplantation of Bone Marrow Mesenchymal Stem Cells on Collagen Scaffolds for the Functional Regeneration of Injured Rat Uterus
Researchers investigated the effect of collagen/bone marrow-derived mesenchymal stem cells constructs in the healing of severe uterine injury in rats (partial full thickness uterine excision). [Biomaterials] Abstract

Cryopreserved Dentin Matrix as a Scaffold Material for Dentin-Pulp Tissue Regeneration
Scientists hypothesized that the cryopreservation could effectively maintain the survival and viability of dentinogenesis-related proteins of treated dentin matrix and the cryopreserved dentin matrix would provide the suitable biological scaffold and inductive microenvironment for the regeneration of dentin-pulp like tissue. [Biomaterials] Abstract

Three-Dimensional Hydrogel Scaffolds Facilitate In-Vitro Self-Renewal of Human Skin-Derived Precursors
Taking the physiological micro-environment of human skin-derived precursors (hKSPs) into consideration, scientists sought to establish a hydrogel scaffold-based three-dimensional culture system for hSKPs. [Acta Biomater] Abstract

A Novel Peptide-Based Platform for the Dual Presentation of Biologically-Active Peptide Motifs on Biomaterials
Investigators introduce a novel peptide-based divalent platform with the capacity to simultaneously present distinct bioactive peptide motifs in a chemically controlled fashion. [ACS Appl Mater Interfaces] Abstract

Comparative Proteomic Analysis of Human Lung Telocytes with Fibroblasts
Investigators examined the molecular aspects of lung telocytes (TCs) by comparison with fibroblasts. TC proteins with known identities are localized in the cytoskeleton and plasma membrane, while fibroblast up-regulated proteins are in the cytoskeleton and destined to extracellular matrix. [J Cell Mol Med] Full Article

Fibroblast-Like Cells Differentiated from Adipose-Derived Mesenchymal Stem Cells for Vocal Fold Wound Healing
Scientists implanted fibroblast-like cells differentiated from adipose-derived mesenchymal stem cells in a canine acute vocal fold wound model. Investigators then sought to characterize changes in the extracellular matrix proteins of vocal fold lamina propria. [PLoS One] Full Article

Adapted Chondrogenic Differentiation of Human Mesenchymal Stem Cells via Controlled Release of TGF-β1 from Poly(Ethylene Oxide)-Terephtalate / Poly(Butylene Terepthalate) Multiblock Scaffolds
Investigators evaluated the ability of porous scaffolds composed of poly(ethylene oxide)-terephtalate and poly(butylene terepthalate) to release bioactive TGF-β1 for chondrogenesis of human bone marrow mesenchymal stem cells in a pellet culture model. [J Biomed Mater Res A] Abstract

Free Cell Stem Cell Poster: Directed Differentiation of ESCs/iPSCs
Cysteine Cathepsins and Extracellular Matrix Degradation
This review focuses on cysteine cathepsins and their extracellular functions linked with ECM degradation, including regulation of their activity, which is often enhanced by acidification of the extracellular microenvironment, such as found in the bone resorption lacunae or tumor microenvironment. [Biochim Biophys Acta] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

International Society for Matrix Biology (ISMB)
ACell Enters National Purchasing Agreement with Novation, Awarded Innovative Technology Designation for MatriStem® Devices
ACell, Inc. announced that it has entered into a national purchasing agreement with Novation for the company’s MatriStem® devices. The MatriStem devices also were awarded the elite Innovative Technology designation from Novation, a health care supply chain expertise, analytics and contracting company. [ACell, Inc.] Press Release

Halozyme Announces that Consistent 1 Trial of Hylenex® Recombinant Met Primary Endpoint
Halozyme Therapeutics, Inc. announced that the primary endpoint of non-inferiority of A1C levels at six months was met for the CONSISTENT 1 trial. The trial is evaluating Hylenex® recombinant and a new formulation of Hylenex currently under U.S Food and Drug Administration review, when used as pretreatment of the insulin infusion site in patients with type 1 diabetes receiving continuous subcutaneous insulin infusion in comparison to no pre-treatment. [Halozyme Therapeutics, Inc.] Press Release

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Therapeutic Goods Administration (Australia)
NEW International Society for Stem Cell Research (ISSCR) 12th Annual Meeting
June 18-21, 2014
Vancouver, Canada

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Postdoctoral Position – Extracellular RNA Bioinformatics and Biology (Univeristy of California, Los Angeles)

NEW Postdoctoral Researcher – Signaling Mechanisms of GPCRs and Wnts and Their In Vivo Functions (Yale University)

NEW Postdoctoral Fellow – Cell Biology, Protein Trafficking, Kidney Physiology (Harvard Medical School)

NEW Postdoctoral Position – Macromolecule Stabilization (University of Minnesota)

NEW Postdoctoral Position – Therapeutic Advantages of the Combined Use of Scaffold and Cells for Orthopedic Applications (Bone Therapeutics S.A.)

NEW Postdoctoral Research Associate – Extracellular Microenvironment in Cancer (Institute of Translational Medicine, University of Liverpool)

NEW Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

PhD Position – 3D Structured Self-Assembled Hydrogels for Tissue Engineering (TU Delft)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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