Volume 5.05 | Feb 13

Extracellular Matrix News 5.05 February 13, 2014
Extracellular Matrix News
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Hyaluronan Digestion Controls DC Migration from the Skin
The breakdown and release of hyaluronan (HA) from the extracellular matrix has been hypothesized to act as an endogenous signal of injury. To test this hypothesis, researchers generated mice that conditionally overexpressed human hyaluronidase 1 (HYAL1). Mice expressing HYAL1 in skin either during early development or by inducible transient expression exhibited extensive HA degradation, yet displayed no evidence of spontaneous inflammation. [J Clin Invest] Full Article
Derivation of Metabolically Active Hepatocytes from Pluripotent Stem Cells - View On-Demand Webinar Now.
PUBLICATIONS (Ranked by impact factor of the journal)
Targeting Fibronectins of Glioma Extracellular Matrix by CLT1 Peptide-Conjugated Nanoparticles
In this study, a drug delivery system targeting fibronectins (FNs), a prevailing component in the extracellular matrix of many solid tumors, was constructed for glioma therapy based on the interaction between the abundant FNs in glioma tissues and the FNs-targeting moiety CLT1 peptide. [Biomaterials] Abstract

Oxidation Modifies the Structure and Function of the Extracellular Matrix Generated by Human Coronary Artery Endothelial Cells
Researchers investigated the effect of peroxynitrous acid, an oxidant generated by activated macrophages, on the structure and function of the extracellular matrix laid down by human coronary artery endothelial cells in vitro and in vivo. [Biochem J] Abstract

Vascular Morphogenesis of Human Umbilical Vein Endothelial Cells on Cell-Derived Macromolecular Matrix Microenvironment
Investigators hypothesize that extracellular matrix derived from in vitro cultured cells possesses unique surface texture, topography and mechanical property, and consequently carry some distinct cues for vascular morphogenesis of human umbilical vein endothelial cells. [Tissue Eng Part A] Abstract

A Combination of Biphasic Calcium Phosphate Scaffold with Hyaluronic Acid-Gelatin Hydrogel as a New Tool for Bone Regeneration
Hyaluronic acid-Gelatin hydrogel was loaded into a biphasic calcium phosphate ceramic, and the resulting scaffold, with unique micro and macro porous orientation, was evaluated for bone regeneration applications. [Tissue Eng Part A] Abstract

Non-Replicating Mycobacterium tuberculosis Elicits a Reduced Infectivity Profile with Corresponding Modifications to the Cell Wall and Extracellular Matrix
Non-replicating persistent (NRP) M. tuberculosis was established by the gradual depletion of nutrients in an oxygen-replete and controlled environment. In contrast to rapidly dividing bacilli, NRP bacteria exhibited a distinct phenotype by accumulating an extracellular matrix rich in free mycolate and lipoglycans, with increased arabinosylation. [PLoS One] Full Article

Opposing Effects of Collagen I and Vitronectin on Fibronectin Fibril Structure and Function
The authors compared effects of cell adhesion to vitronectin versus type I collagen on the assembly of and response to, extracellular matrix fibronectin fibrils. The amount of insoluble fibronectin matrix fibrils assembled by fibronectin-null mouse embryonic fibroblasts adherent to collagen- or vitronectin-coated substrates was not significantly different 20 hours after fibronectin addition. [Matrix Biol] Abstract

Optimum Temperature for Extracellular Matrix Production by Articular Chondrocytes
Researchers investigated the influence of temperature on the ability of the chondrocytes to produce extracellular matrix (ECM). The ability to produce ECM was assessed by gene expression analysis, histological, and biochemical evaluation in a pellet culture system. [Int J Hyperthermia] Abstract

Effects of ECM Protein Mimetics on Adhesion and Proliferation of Chorion Derived Mesenchymal Stem Cells
Scientists evaluated the effects of fibronectin, collagen, cadherin, and laminin based extracellular matrix (ECM) protein mimetics coated with mussel derived adhesive protein on adhesion and proliferation of chorionic mesenchymal stem cells. [Int J Med Sci] Abstract

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Request Your Free Wallchart: Mesenchymal Stem Cells (A Nature Reviews Molecular Cell Biology Collaboration)
Myofibroblasts and the Extracellular Matrix Network in Post-Myocardial Infarction Cardiac Remodeling
The authors summarize the current literature on the roles of myofibroblasts, matrix metalloproteinases, and extracellular matrix (ECM) proteins in myocardial infarction-induced left ventricle remodeling. In addition, they discuss future research directions that are needed to further elucidate the molecular mechanisms of ECM actions to optimize cardiac repair. [Pflugers Arch] Full Article

Mesenchymal Stem Cells, Neural Lineage Potential, Heparan Sulphate Proteoglycans and the Matrix
The authors summarize the current literature and highlight the potential for heparan sulphate proteoglycans directed neural lineage fate specification in human mesenchymal stem cells, which may provide a new model for brain damage repair. [Dev Biol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
ACell Launches New MatriStem® Multilayer Wound Matrix Device
ACell, Inc. announced that it has launched the new MatriStem® Multilayer Wound Matrix device for deep, hard-to-heal, full-thickness wounds. The 1:1 mesh design of MatriStem Multilayer Wound Matrix is built to accommodate moderate to heavy wound exudate and provides effective contouring functionality in wound application. [ACell, Inc.] Press Release

Admedus’s CardioCel® Cleared for Sale in the US
Admedus announced it has received FDA clearance to market CardioCel® in the US. CardioCel® is the group’s lead regenerative tissue product to repair and treat a range of cardiovascular and vascular defects. The company will now look to complement its existing product launch in Europe with preparation for initial sales in the US. [BusinessWire] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW American Society for Matrix Biology (ASMB) 2014
October 12-15, 2014
Cleveland, United States

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

NEW Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

NEW Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Mechanism of Remodeling in Heart and Vascular Diseases (University of Alberta)

Faculty Position – Cervical Biology (Wayne State University School of Medicine)

Postdoctoral Position – Development of Uni-Lamellar Scaffolds for Bio-Mineralization in Bone Repair (Fujifilm)

MSc Studentship – Soft Tissue Nanomechanics (Saint Mary’s University)

Postdoctoral Researcher – Mechanisms of Angiogenesis and Vasculogenesis during Development and Retinal Diseases (State University of New York)

Postdoctoral Fellow – Extracellular Matrix-Integrin Signaling and Trafficking of Membrane Transporters (Massachusetts General Hospital)

PhD Studentships – Collagen IV and Angiogenesis (University of East Anglia)

Postdoctoral Research Fellow – Mechanobiology, Fibroblasts and Matrix Biology (Mayo Clinic)

Postdoctoral Position – Stem Cells and Bioengineering (Queensland University of Technology/Translational Research Institute)

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