|PUBLICATIONS (Ranked by impact factor of the journal)|
Comparative Decellularization and Recellularization of Normal versus Emphysematous Human Lungs|
Cadaveric human lungs from normal patients and from patients with chronic obstructive pulmonary disease (COPD) were decellularized and found by histochemical and immunohistochemical staining, electron microscopy, and mass spectrometry to retain characteristic histological architecture and extracellular matrix components reflecting either normal or COPD, particularly emphysematous, origin. [Biomaterials]
Direct Cytocidal Effect of Galectin-9 Localized on Collagen Matrices on Human Immune Cell Lines
An attempt was made to develop new collagen matrices, which can cause local, contact-dependent immune suppression, using galectin-9 and collagen-binding galectin-9 fusion proteins as active ingredients. [Biochim Biophys Acta]
Developmentally Regulated Collagen/Integrin Interactions Confer Adhesive Properties to Early Postnatal Neural Stem Cells
To examine the specific adhesive properties of young stem cells in more detail, neural stem and progenitor cells isolated from embryonic, postnatal day 6, and adult mouse brains were cultured on collagen I. [Biochim Biophys Acta]
Hsp90 Binds Directly to Fibronectin (FN) and Inhibition Reduces the Extracellular Fibronectin Matrix in Breast Cancer Cells
Exogenous heat shock protein 90 (Hsp90)β was shown to increase the formation of extracellular FN matrix in the Hs578T cell line, whilst knockdown or inhibition of Hsp90 led to a reduction in the levels of both soluble and insoluble FN and could be partially rescued by addition of exogenous Hsp90β. [PLoS One]
CADM1 Controls Actin Cytoskeleton Assembly and Regulates Extracellular Matrix Adhesion in Human Mast Cells
The authors investigated a role for CADM1 in mast cell (MC) adhesion to both cells and extracellular matrix (ECM). Downregulation of CADM1 in the human MC line HMC-1 resulted not only in reduced adhesion to human airway smooth muscle cells, but also reduced adhesion to their ECM. [PLoS One]
Extracellular Matrix Remodeling following Myocardial Infarction Influences the Therapeutic Potential of Mesenchymal Stem Cells
Mechanical and compositional changes to the decellularized infarcted myocardium were characterized to understand how the extracellular environment, specifically, was altered as a function of time following coronary artery ligation in Sprague-Dawley rats. [Stem Cell Res Ther]
Microablation of Collagen-Based Substrates for Soft Tissue Engineering
Through the use of excimer-laser technology, investigators have optimized conditions for the ablation of collagen lamellae without denaturation of protein, maintenance of fibrillar ultrastructure and preservation of native D-periodicity. [Biomed Mater]
Robotic Operation for Heart Valve Reconstruction Performed at Temple University Hospital Holds Promise for Patients with Infective Endocarditis|
A potentially fatal bacterial disease of the heart, infective endocarditis frequently affects the heart’s tricuspid valve, often resulting in permanent tissue damage. But a reconstructive technique, in which the valve is repaired with a bioscaffold on which new tissue can grow, can give some patients a new lease on life-a lease that has been extended to patients, thanks to the pioneering work of T. Sloane Guy at Temple University School of Medicine. [Temple University Health System, Inc.]
Halozyme Announces Positive Opinion from CHMP For European Approval of Roche’s MabThera SC
Halozyme Therapeutics, Inc. announced that the EU Committee for Medicinal Products for Human Use (CHMP) has recommended that the European Commission approve Roche’s subcutaneous (SC) formulation of MabThera® using Halozyme’s recombinant human hyaluronidase for the treatment of patients with common forms of non-Hodgkin lymphoma. [Halozyme Therapeutics, Inc.]
Cardium Announces Strategic Focus on Advanced Regenerative Therapeutics Based on Generx Clinical Findings
Cardium Therapeutics Inc. reported on the Company’s strategic focus on its two advanced regenerative medicine therapeutics, based on encouraging preliminary findings from its Generx® Aspire International Phase III registration clinical study, and data on the utility of Excellagen® for wound healing and as a biologics delivery platform. [Cardium Therapeutics Inc.]
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