Volume 5.01 | Jan 16

Extracellular Matrix News 5.01 January 16, 2014
Extracellular Matrix News
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The Effect of Mechanical Stimulation on the Maturation of TDSCs-Poly(L-lactide-co-e-caprolactone)/Collagen Scaffold Constructs for Tendon Tissue Engineering
Investigators assessed the efficacy of tendon-derived stem cells (TDSCs) in a poly(L-lactide-co-ε-caprolactone)/collagen scaffold under mechanical stimulation for tendon tissue engineering both in vitro and in vivo, and evaluated the utility of the transplanted TDSCs-scaffold construct to promote rabbit patellar tendon defect regeneration. [Biomaterials] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
A Collagen-Based Scaffold Delivering Exogenous MicroRNA-29B to Modulate Extracellular Matrix Remodeling
Scientists hypothesized that delivery of microRNA-29B from a collagen scaffold will efficiently modulate the extracellular matrix remodeling response and reduce maladaptive remodeling such as aggressive deposition of collagen type I after injury. The release of RNA from the scaffold was assessed and its ability to silence collagen type I and collagen type II expression was evaluated in vitro. [Mol Ther] Abstract

A Biomimetic Multi-Layered Collagen-Based Scaffold for Osteochondral Repair
This study focuses on the development of a layered construct for osteochondral repair, fabricated through a novel “iterative layering” freeze-drying technique. The process involved repeated steps of layer addition followed by freeze-drying, enabling control over material composition, pore size and substrate stiffness in each region of the construct, while also achieving a seamlessly integrated layer structure. [Acta Biomater] Abstract

Cellular Traction Stresses Mediate Extracellular Matrix Degradation by Invadopodia
To determine the relationship between cellular traction stresses and invadopodia activity, researchers characterized the invasive and contractile properties of an aggressive carcinoma cell line utilizing polyacrylamide gels of different rigidities. They found that extracellular degradation and traction stresses were linear functions of matrix rigidity. [Acta Biomater] Abstract

Stromal Fibroblasts Mediate Extracellular Matrix Remodeling and Invasion of Scirrhous Gastric Carcinoma Cells
The authors investigated the role of stromal fibroblasts (SFs) in the invasion of the extracellular matrix (ECM) by scirrhous gastric carcinoma (SGC) cells. When SGC cells were cocultured with SFs derived from SGC tissue on three-dimensional Matrigel, they were attracted together to form large cellular aggregates that invaded within the Matrigel. [PLoS One] Full Article

Quantification of Magnetically Induced Changes in ECM Local Apparent Stiffness
Investigators describe an approach to manipulating the stiffness of extracellular matrix (ECM), whereby magnetic beads are embedded in the ECM through bioconjugation between the streptavidin-coated beads and the collagen fibers and then manipulated by an external magnetic field. [Biophys J] Abstract

Albumin Fiber Scaffolds for Engineering Functional Cardiac Tissues
Scientists fabricated aligned and randomly oriented electrospun albumin fibers and investigated their structure, mechanical properties, and chemical nature. Their measurements showed that the scaffolds have improved elasticity as compared to synthetic electrospun PCL fibers, and that they are capable of adsorbing serum proteins, such as laminin leading to strong cell-matrix interactions. [Biotechnol Bioeng] Abstract

Impact of High-/Middle-Molecular-Weight Adiponectin on the Synthesis and Regulation of Extracellular Matrix in Dermal Fibroblasts
The authors compared the mRNA levels of collagen type1, fibronectin 1, matrix metalloproteinase 1, -3, TIMP1, -3, TGF-β, and TGF-β receptor 2 in human normal dermal fibroblasts cultured with and without adiponectin, and assessed the degree of synthesis of extracellular matrices by immunofluorescent microscopy. [Exp Hematol] Abstract

Crosslinking of Saphenous Vein ECM by Procyanidins for Small Diameter Blood Vessel Replacement
To overcome the drawbacks of pure and glutaraldehyde-crosslinked vascular alternatives of small-diameter blood vessels, procyanidins, a naturally derived polyphenol with anti-inflammatory and platelet aggregation inhibiting bioactivities, was applied to crosslink the decellularized bovine saphenous vein extracellular matrix (ECM). [J Biomed Mater Res Part B] Abstract

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Decellularized Tissue and Cell-Derived Extracellular Matrices as Scaffolds for Orthopedic Tissue Engineering
Although decellularized bone tissue is widely used clinically in orthopedic applications, the exciting potential of decellularized cartilage, skeletal muscle, tendon and ligament cell-derived matrices has only recently begun to be explored for ultimate translation to the orthopedic clinic. [Biotechnol Adv] Abstract

Extracellular Matrix: A Dynamic Microenvironment for Stem Cell Niche
The authors overview the progresses that have been made in elucidating stem cell niches and discuss the mechanisms by which extracellular matrix (ECM) affects stem cell behavior. They also summarize the current tools and experimental models for studying ECM-stem cell interactions. [Biochim Biophys Acta] Full Article

Engineering the Extracellular Matrix for Clinical Applications: Endoderm, Mesoderm, and Ectoderm
The authors discuss advantages and challenges of optimized cell scaffold design in the endoderm, mesoderm, and ectoderm for clinical applications in tracheal transplant, cardiac regeneration, and skin grafts, respectively. [Biotechnol J] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
CorMatrix® Cardiovascular, Inc. Receives Core U.S. Patent for Injectable Biomaterial
CorMatrix® Cardiovascular, Inc. announced the issuance of U.S. Patent No. 8,568,761 for an augmented injectable extracellular matrix (ECM®) bioscaffold. The augmented ECM® bioscaffold induces stem cell proliferation and differentiation of stem cells into cardiomyocytes, and, thereby, angiogenesis and remodeling, i.e. tissue repair, of cardiovascular tissue. [Business Wire] Press Release

Plant Cell Growth Studies Funded by NSF Grant at UMass Amherst
Plant cell biologist Magdalena Bezanilla at the University of Massachusetts Amherst has received a four-year, $600,000 grant from the National Science Foundation (NSF) to further her award-winning research on fundamental processes of plant growth, in particular how molecules secreted by cells help to determine their outer shapes and patterns. [University of Massachusetts Amherst] Press Release

ACell Initiates Post-Market Comparative Study of MatriStem® versus Dermagraft® in Patients with Diabetic Foot Ulcers
ACell, Inc. announced it has initiated, with multiple patients enrolled, a U.S. post-market clinical trial comparing the efficacy of MatriStem® to a leading cellular scaffold, Dermagraft®, for the treatment of patients with diabetic foot ulcers that failed to adequately heal following initial standard of care therapy. [ACell, Inc.] Press Release

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European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW The Musculoskeletal System from Development to Disease
September 1-2, 2014
Norwich, United Kingdom

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NEW Postdoctoral Researcher – Mechanisms of Angiogenesis and Vasculogenesis during Development and Retinal Diseases (State University of New York)

Postdoctoral Training Fellow – Proteomics and Cancer Biology (The Institute of Cancer Research)

Postdoctoral Fellow – Extracellular Matrix-Integrin Signaling and Trafficking of Membrane Transporters (Massachusetts General Hospital)

PhD Studentships – Collagen IV and Angiogenesis (University of East Anglia)

Postdoctoral Research Fellow – Mechanobiology, Fibroblasts and Matrix Biology (Mayo Clinic)

Postdoctoral Position – Stem Cells and Bioengineering (Queensland University of Technology/Translational Research Institute)

Postdoctoral Fellow – Wound Healing/Fibrosis Research (University of Connecticut Health Center)

Postdoctoral Fellow – Liver Tissue Engineering (Massachusetts General Hospital and Harvard Medical School)

Postdoctoral Position – Tissue Engineering (Weizmann Institute of Science)

PhD Position – Molecular Cell Biology (Weizmann Institute of Science)

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