Volume 4.48 | Dec 5

Extracellular Matrix News 4.48 December 5, 2013
Extracellular Matrix News
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The Adipogenic Potential of Various Extracellular Matrices Under the Influence of an Angiogenic Growth Factor Combination in a Mouse Tissue Engineering Chamber
Investigators sought to compare the adipogenic potential of a number of alternative, biologically derived or synthetic extracellular matrices with potential for human application, with and without growth factors and a small fat autograft. [Acta Biomater] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Heart-Specific Stiffening in Early Embryos Parallels Matrix and Myosin Expression to Optimize Beating
Sparsely cultured embryonic day 4 (E4) cardiomyocytes on collagen-coated gels showed maximal contraction on matrices with native E4 stiffness, highlighting cell-intrinsic mechanosensitivity. [Curr Biol]
| Graphical Abstract

Matrilin-1 is Essential for Zebrafish Development by Facilitating Collagen II Secretion
The authors used the zebrafish as an alternative model to study matrilin function in vivo. Matrilin-1 displays a multiphasic expression during zebrafish development. [J Biol Chem] Abstract | Full Article

First Clinical Application of Octacalcium Phosphate Collagen Composite in Human Bone Defect
This study investigated the bone regeneration of octacalcium phosphate (OCP)/collagen in human bone defect as a first clinical trial. Two patients who had a radicular cyst or apical periodontitis consented to participate in the clinical study and OCP/collagen was implanted into the defects after operation. [Tissue Eng Part A] Abstract

MicroRNA-143 Regulates Collagen Type III Expression in Stromal Fibroblasts of Scirrhous Type Gastric Cancer
Scientists identified several microRNAs (miRNAs) that are expressed at higher level in scirrhous type gastric cancer (GC) than in non-scirrhous type GC by miRNA microarray analysis. Among these, miR-143 expression was higher in scirrhous type GC than in non-scirrhous types of GC. In situ hybridization and quantitative RT-PCR analysis showed that miR-143 is expressed by stromal fibroblasts but not by cancer cells. [Cancer Sci] Abstract

Extracellular Matrix Proteins: A Positive Feedback Loop in Lung Fibrosis?
The authors describe the expression of elastin, type V collagen and tenascin C during the development of bleomycin-induced lung fibrosis. They further report in vitro experiments clarifying both the effect of myofibroblast differentiation on this expression and the effect of extracellular elastin on myofibroblast differentiation. [Matrix Biol] Abstract

Down-Regulation of Collagen Synthesis and Matrix Metalloproteinase Expression in Myofibroblasts from Dupuytren Nodule Using Adenovirus-Mediated Relaxin Gene Therapy
Investigators studied the effect of the relaxin gene on the inhibition of fibrosis in myofibroblastic cells. Myofibroblast cells with adenovirus LacZ as a marker gene or adenovirus relaxin as therapeutic gene showed transgene expressions in beta-galactosidase assay and Western blot analysis. [J Orthop Res] Abstract

The Effects of Platelet-Rich Clot Releasate on the Expression of MMP-1 and Type I Collagen in Human Adult Dermal Fibroblasts: PRP Is a Stronger MMP-1 stimulator
Whether or not platelet-rich clot releasate (PRCR) is able to effectively modulate the extracellular matrix, and the effect of PRCR on the expression of type I collagen and matrix metalloproteinase (MMP)-1 in human dermal fibroblasts was evaluated. [Mol Biol Rep] Abstract

Age-Related Disruption of Autophagy in Dermal Fibroblasts Modulates Extracellular Matrix Components
Researchers examined the relationship between autophagy and skin aging. Transmission electron microscopy and immunofluorescence microscopy analyses of skin tissue and cultured dermal fibroblasts derived from women of different ages revealed an increase in the number of nascent double-membrane autophagosomes with age. [Biochem Biophys Res Commun] Abstract

Effect of Hyaluronic Acid Incorporation Method on the Stability and Biological Properties of Polyurethane-Hyaluronic Acid Biomaterials
The authors examined whether the method of biomolecule incorporation (i.e., bulk versus surface modification) into a polyurethane (PU) polymer impacted biomaterial performance in the context of vascular applications. Specifically, hyaluronic acid (HA) was incorporated into a poly(ether urethane) via bulk copolymerization or covalent surface tethering, and the resulting PU-HA materials characterized with respect to both physical and biological properties. [J Mater Sci Mater Med] Abstract

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Leptospiral Extracellular Matrix Adhesins as Mediators of Pathogen-Host Interactions
This review summarizes the current knowledge of bacterial attachment to extracellular matrix components and discusses the possible role of these interactions for leptospiral pathogenesis. [FEMS Microbiol Lett] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Recognition for Tissue Engineering Success
Professor Neil Broom, winner of this year’s MacDiarmid Medal from the Royal Society of New Zealand, used skills and techniques honed in metallurgy and applied them to solve complex problems of biological tissue structure. [The University of Auckland] Press Release

BioCell Technology Awarded U.S. Patent on BioCell Collagen for Methods of Promoting Skin and Joint Health
BioCell Technology, LLC announces that the United States Patent and Trademark Office has granted US Patent 8,563,045 pertaining to the dietary ingredient BioCell Collagen™ to BioCell Technology. BioCell Collagen™ is a patented nutraceutical ingredient comprised of naturally occurring hydrolyzed collagen type II, chondroitin sulfate, and hyaluronic acid in a matrix form. [BioCell Technology, LLC] Press Release

Osiris Provides Update on Proposed Ruling by CMS
Osiris Therapeutics, Inc. announced that, on November 27, 2013, the Centers for Medicare and Medicaid Services (CMS) released their proposed ruling for the reimbursement of skin substitutes in the hospital outpatient setting. CMS decided to package the reimbursement for products used in advanced wound care with the related surgical procedure into a two-tier system. [Osiris Therapeutics, Inc.] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 26th Annual Conference of the European Society for Biomaterials (ESB)
August 31-September 3, 2014
Liverpool, United Kingdom

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Postdoctoral Fellow – Wound Healing/Fibrosis Research (University of Connecticut Health Center)

Postdoctoral Fellow – Liver Tissue Engineering (Massachusetts General Hospital and Harvard Medical School)

PhD Position – Recombinant Collagen Scaffold Design for Tuned Drug Release in Bone Repair (Fraunhofer)

Postdoctoral Research Fellows (Wake Forest Institute for Regenerative Medicine)

Postdoctoral Position – Tissue Engineering (Weizmann Institute of Science)

PhD Position – Molecular Cell Biology (Weizmann Institute of Science)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

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