Volume 4.46 | Nov 21

Extracellular Matrix News 4.46 November 21, 2013
Extracellular Matrix News
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A Collagen-Remodeling Gene Signature Regulated by TGFβ Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer
Researchers identified and validated a ten-gene signature (AEBP1, COL11A1, COL5A1, COL6A2, LOX, POSTN, SNAI2, THBS2, TIMP3, VCAN) that is associated with poor overall survival in patients with high-grade serous ovarian cancer. The signature genes encode extracellular matrix proteins involved in collagen remodeling. [Clin Cancer Res] Abstract
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PUBLICATIONS ( Ranked by impact factor of the journal)
The Localization of Inflammatory Cells and Expression of Associated Proteoglycans in Response to Implanted Chitosan
This study examined the in vivo and in vitro response of mast cells to chitosan, through detection of markers known to be produced by mast cells or involved with the inflammatory response. Mast cells, identified as Leder stained positive cells, were shown to be present in response to material implants. Additionally, the mast cell receptor, c-kit, along with collagen, serglycin, perlecan and chondroitin sulphate were detected within the fibrous capsules, where distribution varied between material implants. [Biomaterials] Abstract

Mechanoregulation of Valvular Interstitial Cell Phenotype in the Third Dimension
The authors characterized the combined effects of boundary stiffness and transforming growth factor-β1 on cell-generated forces and collagen accumulation. [Biomaterials] Abstract

Proteomic Analysis of the Extracellular Matrix Produced by Mesenchymal Stromal Cells: Implications for Cell Therapy Mechanism
To understand the underlying mechanism(s) by which notch1 intracellular domain (NICD)-transfected mesenchymal stromal cells (MSC)-derived extracellular matrix (ECM) supports neural cell growth and survival, scientists investigated the differences in NICD-transfected MSC- and MSC-derived ECM protein quantity and composition. [PLoS One] Full Article

Factors Involved in Extracellular Matrix Turnover in Human Derived Cardiomyocytes
Researchers determined that hypoxia and increased TNFα activity likely exert cardioprotective actions by activating the cardiac antifibrogenic factors Apelin and VEGF. In contrast, IL1β is a strong promoter of interstitial collagen remodeling that may contribute to ventricular dilation and heart failure in the ischemic myocardium. [Cell Physiol Biochem] Full Article

Adiponectin Mediated APPL1-AMPK Signaling Induces Cell Migration, MMP Activation, and Collagen Remodeling in Cardiac Fibroblasts
The authors first demonstrated temporal relocalization of cellular APPL1 in response to adiponectin in primary cardiac fibroblasts and that siRNA-mediated knockdown of APPL1 attenuated stimulation of AMPK by adiponectin. The cell surface content of MT1-MMP and activation of MMP2 were induced by adiponectin and these responses were dependent on AMPK signaling. [J Cell Biochem] Abstract

Heparinization of a Biomimetic Bone Matrix: Integration of Heparin during Matrix Synthesis versus Adsorptive Post Surface Modification
Researchers evaluated a contemporary concept of scaffolding in bone tissue engineering in order to mimic functions of the extracellular matrix. The investigated approach considered the effect of the glycosaminoglycan heparin on structural and biological properties of a synthetic biomimetic bone graft material consisting of mineralized collagen. [J Mater Sci Mater Med] Abstract

Adhesive Properties of Clostridium perfringens to Extracellular Matrix Proteins Collagens and Fibronectin
The adhesive properties of Clostridium perfringens to collagens, gelatin, fibronectin (Fn), Fn-prebound collagens, and Fn-prebound gelatin were investigated. C. perfringens could bind to Fn-prebound collagen type II, type III, and gelatin, but not to gelatin or collagens except for collagen type I directly. [Anaerobe] Abstract

View Technical Data: Superior Chondrogenic Differentiation Potential of MesenCult-XF Cultured MSCs
Matrikine and Matricellular Regulators of EGF Receptor Signaling on Cancer Cell Migration and Invasion
The authors summarize findings that point to matrikines that bind specifically to the epidermal growth factor (EGF) receptor as matricellular molecules that enable cancer cell migrational plasticity and promote invasion. [Lab Invest] Full Article

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
Osiris to Present Grafix® Clinical and Scientific Data at 10th Annual Desert Foot High Risk Diabetic Foot Conference
Osiris Therapeutics, Inc. announced that Dr. Matthew Regulski, Medical Director of the Wound Institute of New Jersey, will present clinical trial data, including secondary endpoints, from Osiris’ multi-center, randomized, controlled clinical trial evaluating the safety and effectiveness of Grafix® in patients with chronic diabetic foot ulcers. [Press release from Osiris Therapeutics, Inc. discussing research presented at the 10th Annual Desert Foot High Risk Diabetic Foot Conference, Phoenix] Press Release

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Auxilium Announces Results Of The XIAFLEX® In Dupuytren’s MULTICORD Contracture Trial
Auxilium Pharmaceuticals, Inc. announced the results of the MULTICORD (Multiple Treatment Investigation of Collagenase Optimizing the Resolution of Dupuytren’s) study, an open-label, Phase IIIb study of the treatment of multiple joints injected concurrently. [Auxilium Pharmaceuticals, Inc.] Press Release

Alliqua Announces Transaction with Celgene
Alliqua, Inc. entered into a licensing agreement with Celgene Cellular Therapeutics, a subsidiary of Celgene Corporation, whereby Alliqua received the right to develop and market the advanced wound care products Biovance® and Extracellular Matrix. [Alliqua, Inc.] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW ASME 2014 3rd Global Congress on NanoEngineering for Medicine and Biology
February 2-5, 2014
San Francisco, United States

Visit our events page to see a complete list of events in the extracellular matrix community.
NEW Postdoctoral Fellow – Liver Tissue Engineering (Massachusetts General Hospital and Harvard Medical School)

PhD Position – Recombinant Collagen Scaffold Design for Tuned Drug Release in Bone Repair (Fraunhofer)

Postdoctoral Fellowship – Immune Regulation by Extracellular Matrix Proteins (Johns Hopkins University)

Postdoctoral Research Fellows (Wake Forest Institute for Regenerative Medicine)

PhD Studentship – Collagen IV and Angiogenesis (University of East Anglia)

Postdoctoral Position – Tissue Engineering (Weizmann Institute of Science)

PhD Position – Molecular Cell Biology (Weizmann Institute of Science)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

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